PE20140997A1 - Compuestos 3-fenilsulfanilmetil-biciclo[3.1.0]hexano 4-sustituidos como antagonistas de mglur 2/3 - Google Patents
Compuestos 3-fenilsulfanilmetil-biciclo[3.1.0]hexano 4-sustituidos como antagonistas de mglur 2/3Info
- Publication number
- PE20140997A1 PE20140997A1 PE2013001215A PE2013001215A PE20140997A1 PE 20140997 A1 PE20140997 A1 PE 20140997A1 PE 2013001215 A PE2013001215 A PE 2013001215A PE 2013001215 A PE2013001215 A PE 2013001215A PE 20140997 A1 PE20140997 A1 PE 20140997A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- phenylsulphanyl
- mglur
- antagonists
- bicycle
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 Y R2 SON INDEPENDIENTEMENTE H, ALCOXICARBONILOXIMETILO C1-C3, ALQUILCARBONILOXIMETILO C1-C5, O CICLOALQUILCARBONILOXIMETILO C3-C6; R3 ES METILO, FLUORO O CLORO; R4 ES HIDROXILO, AMINO, METILCARBONILAMINO, 1,2,4-TRIAZOLILTIO; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: ACIDO (1S,2R,3S,4S,5R,6R)-2-AMINO-3-{[(3,4-DIFLUOROFENIL)SULFANIL]METIL}-4-HIDROXIBICICLO[3.1.0]HEXAN-2,6-DICARBOXILICO; BIS({[(1-METILETOXI)CARBONIL]OXI}METIL)(1S,2R,3S,4S,5R,6R)-2-AMINO-3-{[(3,4-DIFLUOROFENIL)SULFANIL]METIL}-4-HIDROXIBICICLO[3.1.0]HEXAN-2,6-DICARBOXILATO; ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41512110P | 2010-11-18 | 2010-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140997A1 true PE20140997A1 (es) | 2014-08-25 |
Family
ID=45099188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013001215A PE20140997A1 (es) | 2010-11-18 | 2011-11-15 | Compuestos 3-fenilsulfanilmetil-biciclo[3.1.0]hexano 4-sustituidos como antagonistas de mglur 2/3 |
Country Status (36)
Country | Link |
---|---|
US (1) | US8629169B2 (es) |
EP (1) | EP2640697B1 (es) |
JP (1) | JP5877847B2 (es) |
KR (2) | KR20150140876A (es) |
CN (1) | CN103228625B (es) |
AR (1) | AR083845A1 (es) |
AU (1) | AU2011329076B2 (es) |
BR (1) | BR112013012118A2 (es) |
CA (1) | CA2818116C (es) |
CL (1) | CL2013001345A1 (es) |
CO (1) | CO6761385A2 (es) |
CR (1) | CR20130178A (es) |
DK (1) | DK2640697T3 (es) |
DO (1) | DOP2013000099A (es) |
EA (1) | EA021724B1 (es) |
EC (1) | ECSP13012629A (es) |
ES (1) | ES2650139T3 (es) |
GT (1) | GT201300126A (es) |
HR (1) | HRP20171649T1 (es) |
HU (1) | HUE037457T2 (es) |
IL (1) | IL225843A (es) |
LT (1) | LT2640697T (es) |
MA (1) | MA34663B1 (es) |
MX (1) | MX339973B (es) |
NO (1) | NO2640697T3 (es) |
NZ (1) | NZ609816A (es) |
PE (1) | PE20140997A1 (es) |
PL (1) | PL2640697T3 (es) |
PT (1) | PT2640697T (es) |
RS (1) | RS56535B1 (es) |
SG (1) | SG189959A1 (es) |
SI (1) | SI2640697T1 (es) |
TW (1) | TWI520935B (es) |
UA (1) | UA110039C2 (es) |
WO (1) | WO2012068067A1 (es) |
ZA (1) | ZA201302918B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
EP3000814A1 (en) | 2014-09-26 | 2016-03-30 | Domain Therapeutics | Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors |
SG10202006019YA (en) | 2016-04-18 | 2020-08-28 | Taisho Pharmaceutical Co Ltd | Prodrug of amino acid derivative |
US11173145B2 (en) | 2017-01-17 | 2021-11-16 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
WO2020018670A1 (en) * | 2018-07-17 | 2020-01-23 | Board Of Regents, The University Of Texas System | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0669928B2 (ja) | 1987-10-06 | 1994-09-07 | 宇部興産株式会社 | 光重合性歯科材料 |
JP2589812B2 (ja) | 1989-07-05 | 1997-03-12 | 松下電器産業株式会社 | スチームアイロン |
ZA969485B (en) | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
CN1202103A (zh) | 1995-11-16 | 1998-12-16 | 伊莱利利公司 | 兴奋性的氨基酸受体拮抗剂 |
ZA983930B (en) * | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
AU753422B2 (en) | 1998-03-17 | 2002-10-17 | Pfizer Products Inc. | Bicyclo(2.2.1)heptanes and related compounds |
GB9815542D0 (en) | 1998-07-17 | 1998-09-16 | Lilly Co Eli | Bicyclohexane derivatives |
CH694053A5 (de) | 1998-09-03 | 2004-06-30 | Hoffmann La Roche | Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten. |
WO2002068380A1 (en) * | 2001-02-22 | 2002-09-06 | Eli Lilly And Company | Synthetic excitatory amino acids |
AU2002359923B2 (en) | 2001-12-27 | 2007-12-20 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
CA2488167C (en) * | 2002-06-11 | 2012-07-24 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
WO2005000790A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | 2-アミノビシクロ[3.1.0]ヘキサン-2,6-ジカルボン酸誘導体 |
KR101071507B1 (ko) | 2003-06-26 | 2011-10-10 | 다이쇼 세이야꾸 가부시끼가이샤 | 2-아미노바이시클로〔3.1.0〕헥산-2,6-디카르복실산 에스테르 유도체 |
JP2007063129A (ja) | 2003-06-26 | 2007-03-15 | Taisho Pharmaceut Co Ltd | 2−アミノ−3−アルコキシビシクロ[3.1.0]ヘキサン誘導体 |
AR079343A1 (es) * | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
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2011
- 2011-11-11 AR ARP110104219A patent/AR083845A1/es unknown
- 2011-11-11 TW TW100141326A patent/TWI520935B/zh not_active IP Right Cessation
- 2011-11-15 ES ES11791692.4T patent/ES2650139T3/es active Active
- 2011-11-15 EA EA201390498A patent/EA021724B1/ru not_active IP Right Cessation
- 2011-11-15 JP JP2013539938A patent/JP5877847B2/ja active Active
- 2011-11-15 PE PE2013001215A patent/PE20140997A1/es not_active Application Discontinuation
- 2011-11-15 US US13/296,384 patent/US8629169B2/en active Active
- 2011-11-15 LT LTEP11791692.4T patent/LT2640697T/lt unknown
- 2011-11-15 MX MX2013005622A patent/MX339973B/es active IP Right Grant
- 2011-11-15 NZ NZ609816A patent/NZ609816A/en not_active IP Right Cessation
- 2011-11-15 PT PT117916924T patent/PT2640697T/pt unknown
- 2011-11-15 SG SG2013030507A patent/SG189959A1/en unknown
- 2011-11-15 NO NO11791692A patent/NO2640697T3/no unknown
- 2011-11-15 UA UAA201305835A patent/UA110039C2/ru unknown
- 2011-11-15 PL PL11791692T patent/PL2640697T3/pl unknown
- 2011-11-15 EP EP11791692.4A patent/EP2640697B1/en active Active
- 2011-11-15 KR KR1020157034547A patent/KR20150140876A/ko not_active Application Discontinuation
- 2011-11-15 AU AU2011329076A patent/AU2011329076B2/en not_active Ceased
- 2011-11-15 RS RS20171082A patent/RS56535B1/sr unknown
- 2011-11-15 DK DK11791692.4T patent/DK2640697T3/en active
- 2011-11-15 SI SI201131304T patent/SI2640697T1/sl unknown
- 2011-11-15 CA CA2818116A patent/CA2818116C/en active Active
- 2011-11-15 WO PCT/US2011/060730 patent/WO2012068067A1/en active Application Filing
- 2011-11-15 KR KR1020137012697A patent/KR20130101094A/ko active IP Right Grant
- 2011-11-15 HU HUE11791692A patent/HUE037457T2/hu unknown
- 2011-11-15 BR BR112013012118A patent/BR112013012118A2/pt not_active IP Right Cessation
- 2011-11-15 CN CN201180055263.7A patent/CN103228625B/zh active Active
-
2013
- 2013-04-18 IL IL225843A patent/IL225843A/en not_active IP Right Cessation
- 2013-04-22 ZA ZA2013/02918A patent/ZA201302918B/en unknown
- 2013-04-24 CR CR20130178A patent/CR20130178A/es unknown
- 2013-05-08 DO DO2013000099A patent/DOP2013000099A/es unknown
- 2013-05-13 MA MA35898A patent/MA34663B1/fr unknown
- 2013-05-15 GT GT201300126A patent/GT201300126A/es unknown
- 2013-05-15 CL CL2013001345A patent/CL2013001345A1/es unknown
- 2013-05-17 EC ECSP13012629 patent/ECSP13012629A/es unknown
- 2013-05-30 CO CO13133036A patent/CO6761385A2/es unknown
-
2017
- 2017-10-27 HR HRP20171649TT patent/HRP20171649T1/hr unknown
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Legal Events
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