EA201390498A1 - СОЕДИНЕНИЯ 4-ЗАМЕЩЕННОГО-3-ФЕНИЛСУЛЬФАНИЛМЕТИЛБИЦИКЛО[3.1.0]ГЕКСАНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR 2/3 - Google Patents

СОЕДИНЕНИЯ 4-ЗАМЕЩЕННОГО-3-ФЕНИЛСУЛЬФАНИЛМЕТИЛБИЦИКЛО[3.1.0]ГЕКСАНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR 2/3

Info

Publication number
EA201390498A1
EA201390498A1 EA201390498A EA201390498A EA201390498A1 EA 201390498 A1 EA201390498 A1 EA 201390498A1 EA 201390498 A EA201390498 A EA 201390498A EA 201390498 A EA201390498 A EA 201390498A EA 201390498 A1 EA201390498 A1 EA 201390498A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulfanylmethylbiciclo
antagonists
substitute
hexane
phenyl
Prior art date
Application number
EA201390498A
Other languages
English (en)
Other versions
EA021724B1 (ru
Inventor
Стефон Корнелл Смит
Ренуа Ли
Чарльз Говард Митч
Татьяна Натали Ветман
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45099188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390498(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201390498A1 publication Critical patent/EA201390498A1/ru
Publication of EA021724B1 publication Critical patent/EA021724B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms

Abstract

Предложен антагонист рецептора mGlu2/3 формулыего применение и способы его получения.
EA201390498A 2010-11-18 2011-11-15 СОЕДИНЕНИЯ 4-ЗАМЕЩЕННОГО-3-ФЕНИЛСУЛЬФАНИЛМЕТИЛБИЦИКЛО[3.1.0]ГЕКСАНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR 2/3 EA021724B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41512110P 2010-11-18 2010-11-18
PCT/US2011/060730 WO2012068067A1 (en) 2010-11-18 2011-11-15 4-substituted-3-phenylsulfanylmethyl-bicyclo[3.1.0]hexane compounds as mglur 2/3 antagonists

Publications (2)

Publication Number Publication Date
EA201390498A1 true EA201390498A1 (ru) 2013-07-30
EA021724B1 EA021724B1 (ru) 2015-08-31

Family

ID=45099188

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390498A EA021724B1 (ru) 2010-11-18 2011-11-15 СОЕДИНЕНИЯ 4-ЗАМЕЩЕННОГО-3-ФЕНИЛСУЛЬФАНИЛМЕТИЛБИЦИКЛО[3.1.0]ГЕКСАНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR 2/3

Country Status (36)

Country Link
US (1) US8629169B2 (ru)
EP (1) EP2640697B1 (ru)
JP (1) JP5877847B2 (ru)
KR (2) KR20150140876A (ru)
CN (1) CN103228625B (ru)
AR (1) AR083845A1 (ru)
AU (1) AU2011329076B2 (ru)
BR (1) BR112013012118A2 (ru)
CA (1) CA2818116C (ru)
CL (1) CL2013001345A1 (ru)
CO (1) CO6761385A2 (ru)
CR (1) CR20130178A (ru)
DK (1) DK2640697T3 (ru)
DO (1) DOP2013000099A (ru)
EA (1) EA021724B1 (ru)
EC (1) ECSP13012629A (ru)
ES (1) ES2650139T3 (ru)
GT (1) GT201300126A (ru)
HR (1) HRP20171649T1 (ru)
HU (1) HUE037457T2 (ru)
IL (1) IL225843A (ru)
LT (1) LT2640697T (ru)
MA (1) MA34663B1 (ru)
MX (1) MX339973B (ru)
NO (1) NO2640697T3 (ru)
NZ (1) NZ609816A (ru)
PE (1) PE20140997A1 (ru)
PL (1) PL2640697T3 (ru)
PT (1) PT2640697T (ru)
RS (1) RS56535B1 (ru)
SG (1) SG189959A1 (ru)
SI (1) SI2640697T1 (ru)
TW (1) TWI520935B (ru)
UA (1) UA110039C2 (ru)
WO (1) WO2012068067A1 (ru)
ZA (1) ZA201302918B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2978B1 (en) * 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
DK3445743T3 (da) 2016-04-18 2021-10-18 Taisho Pharmaceutical Co Ltd Prodrug af aminosyrederivat
JP2020506895A (ja) 2017-01-17 2020-03-05 ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System インドールアミン２，３−ジオキシゲナーゼおよび／またはトリプトファンジオキシゲナーゼの阻害剤として有用な化合物
US11046649B2 (en) 2018-07-17 2021-06-29 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0669928B2 (ja) 1987-10-06 1994-09-07 宇部興産株式会社 光重合性歯科材料
JP2589812B2 (ja) 1989-07-05 1997-03-12 松下電器産業株式会社 スチームアイロン
EA000894B1 (ru) * 1995-11-16 2000-06-26 Эли Лилли Энд Компани Замещенные бициклогексанкарбоновые кислоты и их производные в качестве антагонистов рецептора возбуждающих аминокислот, способ их получения и применение
ZA969485B (en) 1995-11-16 1998-05-12 Lilly Co Eli Excitatory amino acid receptor antagonists.
ZA983930B (en) * 1997-05-14 1999-11-08 Lilly Co Eli Excitatory amino acid receptor modulators.
EP1064256B1 (en) * 1998-03-17 2004-08-04 Pfizer Products Inc. Bicyclo [2.2.1] heptanes and related compounds
GB9815542D0 (en) 1998-07-17 1998-09-16 Lilly Co Eli Bicyclohexane derivatives
CH694053A5 (de) 1998-09-03 2004-06-30 Hoffmann La Roche Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
WO2002068380A1 (en) * 2001-02-22 2002-09-06 Eli Lilly And Company Synthetic excitatory amino acids
AU2002359923B2 (en) 2001-12-27 2007-12-20 Taisho Pharmaceutical Co., Ltd. 6-fluorobicyclo[3.1.0]hexane derivatives
PT1517915E (pt) * 2002-06-11 2009-04-09 Lilly Co Eli Pró-drogas de amino ácidos de excitação
NZ580554A (en) * 2003-06-26 2011-01-28 Taisho Pharmaceutical Co Ltd 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative
JP2007063129A (ja) 2003-06-26 2007-03-15 Taisho Pharmaceut Co Ltd ２−アミノ−３−アルコキシビシクロ［３．１．０］ヘキサン誘導体
WO2005000790A1 (ja) * 2003-06-26 2005-01-06 Taisho Pharmaceutical Co., Ltd. ２－アミノビシクロ[３．１．０]ヘキサン－２，６－ジカルボン酸誘導体
JO2978B1 (en) * 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids

Also Published As

Publication number Publication date
CO6761385A2 (es) 2013-09-30
MA34663B1 (fr) 2013-11-02
DOP2013000099A (es) 2013-08-15
NO2640697T3 (ru) 2018-02-17
SG189959A1 (en) 2013-06-28
CR20130178A (es) 2013-07-09
WO2012068067A1 (en) 2012-05-24
TW201307271A (zh) 2013-02-16
TWI520935B (zh) 2016-02-11
SI2640697T1 (sl) 2017-11-30
KR20130101094A (ko) 2013-09-12
ZA201302918B (en) 2014-10-29
AU2011329076B2 (en) 2015-03-12
GT201300126A (es) 2014-02-27
IL225843A (en) 2015-05-31
JP2014505664A (ja) 2014-03-06
CA2818116A1 (en) 2012-05-24
RS56535B1 (sr) 2018-02-28
MX339973B (es) 2016-06-20
UA110039C2 (xx) 2015-11-10
CN103228625B (zh) 2014-12-03
AU2011329076A1 (en) 2013-05-02
CA2818116C (en) 2016-04-05
NZ609816A (en) 2014-12-24
HUE037457T2 (hu) 2018-08-28
EA021724B1 (ru) 2015-08-31
JP5877847B2 (ja) 2016-03-08
PT2640697T (pt) 2017-12-11
PL2640697T3 (pl) 2018-02-28
PE20140997A1 (es) 2014-08-25
EP2640697A1 (en) 2013-09-25
US8629169B2 (en) 2014-01-14
KR20150140876A (ko) 2015-12-16
LT2640697T (lt) 2018-01-10
HRP20171649T1 (hr) 2017-12-15
CL2013001345A1 (es) 2013-11-15
ES2650139T3 (es) 2018-01-17
CN103228625A (zh) 2013-07-31
AR083845A1 (es) 2013-03-27
IL225843A0 (en) 2013-06-27
US20120129902A1 (en) 2012-05-24
MX2013005622A (es) 2013-07-05
EP2640697B1 (en) 2017-09-20
ECSP13012629A (es) 2013-07-31
DK2640697T3 (en) 2017-10-23
BR112013012118A2 (pt) 2016-09-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU