PL2593095T3 - (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania - Google Patents
(+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowaniaInfo
- Publication number
- PL2593095T3 PL2593095T3 PL10805351T PL10805351T PL2593095T3 PL 2593095 T3 PL2593095 T3 PL 2593095T3 PL 10805351 T PL10805351 T PL 10805351T PL 10805351 T PL10805351 T PL 10805351T PL 2593095 T3 PL2593095 T3 PL 2593095T3
- Authority
- PL
- Poland
- Prior art keywords
- morphinans
- toll
- antagonists
- receptor
- therapeutic uses
- Prior art date
Links
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 title 1
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/837,545 US20110015219A1 (en) | 2009-07-16 | 2010-07-16 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof |
| PCT/US2010/061699 WO2012008984A1 (en) | 2010-07-16 | 2010-12-22 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| EP10805351.3A EP2593095B1 (en) | 2010-07-16 | 2010-12-22 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| US12/975,407 US9562014B2 (en) | 2009-07-16 | 2010-12-22 | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2593095T3 true PL2593095T3 (pl) | 2019-12-31 |
Family
ID=43754707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10805351T PL2593095T3 (pl) | 2010-07-16 | 2010-12-22 | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9562014B2 (pl) |
| EP (1) | EP2593095B1 (pl) |
| JP (1) | JP5911484B2 (pl) |
| AU (1) | AU2010357625B2 (pl) |
| CA (1) | CA2768199C (pl) |
| ES (1) | ES2728701T3 (pl) |
| PL (1) | PL2593095T3 (pl) |
| WO (1) | WO2012008984A1 (pl) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201809739T4 (tr) * | 2009-07-16 | 2018-07-23 | Mallinckrodt Llc | Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları. |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| MX362857B (es) | 2011-10-26 | 2019-02-20 | Kempharm Inc Star | Acido benzoico, derivados de acido benzoico y conjugados de acido heteroarilcarboxilico de hidromorfona, profarmacos, metodos de elaboracion y uso de los mismos. |
| CN102579444A (zh) * | 2012-01-21 | 2012-07-18 | 张有成 | 青藤碱在制备抑制肿瘤侵袭转移的药物中的应用 |
| GB201308440D0 (en) * | 2013-05-10 | 2013-06-19 | Dalgleish Angus | Therapeutic |
| ES2784690T3 (es) | 2013-12-05 | 2020-09-29 | Univ Bath | Nuevos compuestos opioides y sus usos |
| KR20170094251A (ko) | 2014-12-02 | 2017-08-17 | 켐팜 인코포레이티드 | 옥시모르폰의 벤조산, 벤조산 유도체 및 헤테로아릴 카르복실산 콘쥬게이트, 이의 전구 약물, 제조 방법 및 용도 |
| WO2016152965A1 (ja) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | 低アルブミン血症の改善剤 |
| US9757372B2 (en) * | 2015-03-25 | 2017-09-12 | Taiwanj Pharmaceuticals Co., Ltd. | Toll-like receptor 4 antagonists and use in autoimmune liver diseases |
| WO2017085115A1 (en) * | 2015-11-18 | 2017-05-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating rhabdomyolysis |
| JP2020504127A (ja) * | 2017-01-05 | 2020-02-06 | タイワンジェ ファーマシューティカルズ カンパニー リミテッドＴａｉｗａｎｊ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． | モルフィナン誘導体と自己免疫、炎症または感染に関連する障害の治療に用いるモルフィナン誘導体含有組成物 |
| JP7239554B2 (ja) * | 2017-07-18 | 2023-03-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｔｌｒ７／８アンタゴニストおよびそれらの使用 |
| JP7284764B2 (ja) * | 2018-02-23 | 2023-05-31 | ロデス テクノロジーズ | 新規オピオイド化合物及びその使用 |
| CN109288840A (zh) * | 2018-11-23 | 2019-02-01 | 中国科学院长春应用化学研究所 | 二元纳曲酮衍生物的应用 |
| US20230192715A1 (en) * | 2020-03-24 | 2023-06-22 | University Of Padova | Morphinan isomers and their structural modifications as nmdar antagonists and neuroplastogens |
| CN115260098B (zh) * | 2022-06-09 | 2024-06-04 | 澳门科技大学 | Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用 |
| WO2024204554A1 (ja) * | 2023-03-29 | 2024-10-03 | 日本ケミファ株式会社 | スピロ環状モルヒナン誘導体 |
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| JPS55133360A (en) * | 1979-04-03 | 1980-10-17 | Tatsuya Shono | Preparation of cyclic amine |
| US4521601A (en) | 1981-05-20 | 1985-06-04 | The United States Of America As Represented By The Department Of Health & Human Services | Practical total synthesis unnatural enantiomers of opium-derived morphinans |
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| US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| PT95069B (pt) | 1989-08-24 | 1997-10-31 | Searle & Co | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
| JPH04273880A (ja) * | 1991-02-28 | 1992-09-30 | Ono Pharmaceut Co Ltd | ジヒドロモルヒネ誘導体 |
| ES2121988T3 (es) | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| DE69424853T2 (de) * | 1993-07-23 | 2000-10-05 | Toray Industries, Inc. | Morphinan-derivate und ihre medizinische verwendung |
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| EP2012772A1 (en) | 2006-04-26 | 2009-01-14 | The Uab Research Foundation | Reducing cancer cell invasion using an inhibitor of toll like receptor signaling |
| CN101066948B (zh) | 2007-05-30 | 2012-01-04 | 广东工业大学 | 青藤碱催化氢化还原制备氢化青藤碱的方法 |
| AU2008276385B2 (en) * | 2007-07-17 | 2013-07-18 | SpecGx LLC | Preparation of N-alkylated opiates by reductive amination |
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| CA2702680A1 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| WO2009059048A2 (en) * | 2007-10-30 | 2009-05-07 | The Regents Of The University Of Colorado | (+)-opioids and methods of use |
| JP5688974B2 (ja) | 2007-12-17 | 2015-03-25 | マリンクロッド エルエルシー | （＋）−オピエートの生成のためのプロセスおよび化合物 |
| AU2008338968A1 (en) | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Process for the preparation of buprenorphine and derivatives of buprenorphine |
| CN101265266B (zh) | 2008-04-23 | 2011-12-14 | 南京大学 | 青藤碱衍生物及其制备方法和应用 |
| MX2010013663A (es) | 2008-06-17 | 2011-01-14 | Mallinckrodt Inc | Proceso para la preparacion de compuestos 6-beta-hidroxi morfinanos. |
| WO2010006119A1 (en) | 2008-07-10 | 2010-01-14 | Human Biomolecular Research Institute | Synthesis of metabolically stable agents for alcohol and drug abuse |
| US8252928B2 (en) | 2008-09-16 | 2012-08-28 | Mallinckrodt LLC. | Processes for the synthesis of five and six membered heterocyclic rings |
| WO2010039209A2 (en) | 2008-09-30 | 2010-04-08 | Mallinckrodt Inc. | Processes for the synthesis of tertiary amines |
| EP2352494B1 (en) * | 2008-10-30 | 2019-10-09 | Grünenthal GmbH | Novel and potent tapentadol dosage forms |
| KR20100090155A (ko) * | 2009-02-05 | 2010-08-13 | 엘지전자 주식회사 | 이동 단말기 및 그의 프레즌스 정보 처리방법 |
| JP2012518652A (ja) * | 2009-02-23 | 2012-08-16 | マリンクロッド インコーポレイテッド | （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体 |
| US8563727B2 (en) | 2009-02-23 | 2013-10-22 | Mallinckrodt Llc | (+)-morphinanium N-oxides and processes for their production |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| JP5697215B2 (ja) | 2009-06-11 | 2015-04-08 | マリンクロッド エルエルシー | 触媒的水素移動による６−α−アミノＮ−置換モルフィナンの合成 |
| TR201809739T4 (tr) * | 2009-07-16 | 2018-07-23 | Mallinckrodt Llc | Toll benzeri reseptör 9 antagonistleri olarak (+)-morfinanlar ve bunların terapötik amaçlı kullanımları. |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
-
2010
- 2010-12-22 PL PL10805351T patent/PL2593095T3/pl unknown
- 2010-12-22 CA CA2768199A patent/CA2768199C/en active Active
- 2010-12-22 ES ES10805351T patent/ES2728701T3/es active Active
- 2010-12-22 JP JP2013519642A patent/JP5911484B2/ja not_active Expired - Fee Related
- 2010-12-22 WO PCT/US2010/061699 patent/WO2012008984A1/en not_active Ceased
- 2010-12-22 US US12/975,407 patent/US9562014B2/en active Active
- 2010-12-22 AU AU2010357625A patent/AU2010357625B2/en active Active
- 2010-12-22 EP EP10805351.3A patent/EP2593095B1/en active Active
-
2016
- 2016-09-02 US US15/255,979 patent/US10604488B2/en active Active
-
2020
- 2020-02-03 US US16/779,796 patent/US11142502B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200172488A1 (en) | 2020-06-04 |
| US20110136845A1 (en) | 2011-06-09 |
| US11142502B2 (en) | 2021-10-12 |
| EP2593095B1 (en) | 2019-03-27 |
| JP2013534208A (ja) | 2013-09-02 |
| US9562014B2 (en) | 2017-02-07 |
| CA2768199A1 (en) | 2012-01-19 |
| ES2728701T3 (es) | 2019-10-28 |
| AU2010357625A1 (en) | 2012-03-01 |
| US20170029432A1 (en) | 2017-02-02 |
| AU2010357625B2 (en) | 2015-04-23 |
| JP5911484B2 (ja) | 2016-04-27 |
| US10604488B2 (en) | 2020-03-31 |
| CA2768199C (en) | 2018-08-28 |
| WO2012008984A1 (en) | 2012-01-19 |
| EP2593095A1 (en) | 2013-05-22 |
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