MX2012013075A - Metodos novedosos para preparacion de antagonistas p2x7r. - Google Patents
Metodos novedosos para preparacion de antagonistas p2x7r.Info
- Publication number
- MX2012013075A MX2012013075A MX2012013075A MX2012013075A MX2012013075A MX 2012013075 A MX2012013075 A MX 2012013075A MX 2012013075 A MX2012013075 A MX 2012013075A MX 2012013075 A MX2012013075 A MX 2012013075A MX 2012013075 A MX2012013075 A MX 2012013075A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- novel methods
- p2x7r antagonists
- p2x7r
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención describe métodos novedosos para la síntesis de compuestos de N-indol-3-il-alquilamida sustituido los cuales actúan como antagonistas P2X7R, estos métodos involucran la transposición de un intermediario de oxima.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10162812 | 2010-05-14 | ||
PCT/EP2011/053283 WO2011141194A1 (en) | 2010-05-14 | 2011-03-04 | Novel methods for the preparation of p2x7r antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012013075A true MX2012013075A (es) | 2012-12-17 |
Family
ID=43924014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013075A MX2012013075A (es) | 2010-05-14 | 2011-03-04 | Metodos novedosos para preparacion de antagonistas p2x7r. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20130060047A1 (es) |
EP (2) | EP2569281A1 (es) |
JP (1) | JP2013526496A (es) |
CN (1) | CN102858741A (es) |
AU (1) | AU2011252351A1 (es) |
BR (1) | BR112012028850A2 (es) |
CA (1) | CA2799115A1 (es) |
EA (1) | EA201201548A1 (es) |
IL (1) | IL222948A0 (es) |
MX (1) | MX2012013075A (es) |
SG (1) | SG185400A1 (es) |
WO (1) | WO2011141194A1 (es) |
ZA (1) | ZA201209495B (es) |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
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US2930798A (en) * | 1956-08-03 | 1960-03-29 | Clin Byla Ets | 3-alkanoyl 1-tertiary-amino-alkyl indol oximes and production thereof |
GB832568A (en) * | 1956-08-03 | 1960-04-13 | Clin Byla Ets | Heterocyclic compounds and production thereof |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704546D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SK13422001A3 (sk) | 1999-04-09 | 2002-05-09 | Astrazeneca Ab | Adamantánové deriváty |
SE9901875D0 (sv) | 1999-05-25 | 1999-05-25 | Astra Pharma Prod | Novel compounds |
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904652D0 (sv) | 1999-12-17 | 1999-12-17 | Astra Pharma Prod | Novel Compounds |
SE9904738D0 (sv) | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
WO2003047515A2 (en) | 2001-11-30 | 2003-06-12 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | P2x7 receptor antagonists |
JP2005517684A (ja) | 2001-12-21 | 2005-06-16 | キング ファーマシューティカルズ リサーチ アンド ディベロップメント インコーポレイテッド | チロシル誘導体及びp2x7受容体モジュレーターとしてのそれらの使用 |
SE0200920D0 (sv) | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
JP2006508145A (ja) * | 2002-11-15 | 2006-03-09 | テイボテク・フアーマシユーチカルズ・リミテツド | 抗感染化合物としての置換インドールピリジニウム |
MXPA05007130A (es) | 2002-12-31 | 2005-08-26 | Pfizer Prod Inc | Inhibidores benzamida del receptor p2x7. |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
ATE355273T1 (de) | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
SE0302139D0 (sv) | 2003-07-28 | 2003-07-28 | Astrazeneca Ab | Novel compounds |
SE0302192D0 (sv) | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
WO2005019182A1 (en) | 2003-08-20 | 2005-03-03 | Bayer Healthcare Ag | Pyrazolylmethylbenzamide derivatives as p2xt-receptor antagonists |
GB2422782A (en) | 2003-10-21 | 2006-08-09 | Inspire Pharmaceuticals Inc | Non-nucleotide compositions and method for treating pain |
EP1747206A1 (en) | 2004-04-29 | 2007-01-31 | Abbott Laboratories | Amino-tetrazoles analogues and methods of use |
KR20070011588A (ko) * | 2004-05-17 | 2007-01-24 | 티보텍 파마슈티칼즈 리미티드 | 치환된 1-페닐-1,5-디히드로-피리도-[3,2-b]인돌-2-온 및다른 hiv 억제제의 배합물 |
AR049340A1 (es) * | 2004-05-17 | 2006-07-19 | Tibotec Pharm Ltd | 1- heterociclil - l, 5- dihidro- pirido (3,2-b) indol - 2- onas |
CN1976930B (zh) * | 2004-05-17 | 2011-01-19 | 泰博特克药品有限公司 | 用作抗感染药物的6,7,8,9-取代的1-苯基-1,5-二氢吡啶并(3,2-b)吲哚-2-酮 |
EP1776352A1 (en) | 2004-06-29 | 2007-04-25 | Pfizer Products Inc. | Method for preparing 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h[1,2,4]triazin-2-yl]-benzamide derivatives by deprotecting the hydroxyl-protected precursers |
AU2005258924A1 (en) | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
US7241776B2 (en) | 2004-08-02 | 2007-07-10 | Abbott Laboratories | Cyanoamidine P2X7 antagonists for the treatment of pain |
SA05260265A (ar) | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
SE0402925D0 (sv) | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
BRPI0519287A2 (pt) | 2004-12-24 | 2009-01-06 | Astrazeneca Ab | derivados de amida |
US20080146612A1 (en) | 2005-01-27 | 2008-06-19 | Astrazeneca Ab | Novel Biaromatic Compounds, Inhibitors of the P2X7-Receptor |
US20060211739A1 (en) | 2005-02-08 | 2006-09-21 | Arturo Perez-Medrano | Use of selective P2X7 receptor antagonists |
US7402596B2 (en) | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
WO2006110516A1 (en) | 2005-04-11 | 2006-10-19 | Abbott Laboratories | Acylhydrazide p2x7 antagonists and uses thereof |
EP1885376A1 (en) | 2005-05-05 | 2008-02-13 | Medicure International Inc. | Inhibition of atp-mediated, p2x7 dependent pathways by pyridoxal-5-phosphaste and vitamin b6 related compounds |
US20090124555A1 (en) | 2005-08-29 | 2009-05-14 | Irma Bernatchez-Lemaire | Use of histogranin and histogranin-like compounds as inhibitors of p2x7 receptor function and as anti-arthritic agents |
US20100022531A1 (en) | 2005-09-01 | 2010-01-28 | Renovis, Inc. | Novel compounds as p2x7 modulators and uses thereof |
EP1951689A1 (en) | 2005-11-07 | 2008-08-06 | Abbott Laboratories | P2x7 receptor antagonists and methods of use |
JP2009514952A (ja) | 2005-11-09 | 2009-04-09 | アボット・ラボラトリーズ | P2x7受容体拮抗薬としての2−フェニル−2h−ピラゾール誘導体およびそれの使用 |
US20100184802A1 (en) | 2006-03-16 | 2010-07-22 | Kelly Michael G | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof |
WO2007109154A2 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
MX2008011919A (es) | 2006-03-16 | 2008-11-28 | Renovis Inc | Compuestos de bicicloheteroarilo como moduladores de p2x7 y usos de los mismos. |
TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為p2x7調節劑之雙環雜芳基化合物與其用途 |
JP5306987B2 (ja) | 2006-03-16 | 2013-10-02 | エボテック (ユーエス) インコーポレイテッド | P2x7調節因子としてのビシクロへテロアリール化合物およびその使用 |
WO2007109182A2 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
WO2007141267A1 (en) | 2006-06-06 | 2007-12-13 | Glaxo Group Limited | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
GB0611154D0 (en) | 2006-06-06 | 2006-07-19 | Glaxo Group Ltd | Novel receptor antagonists and their methods of use |
WO2008005368A2 (en) | 2006-06-30 | 2008-01-10 | Abbott Laboratories | Piperazines as p2x7 antagonists |
SI2049478T1 (sl) | 2006-07-06 | 2012-08-31 | Glaxo Group Ltd | Substituirani N-fenilmetil-5-okso-prolin-2-amidi kot antagonisti receptorja P2X7 in postopki za njihovo uporabo |
AU2010237302A1 (en) * | 2009-04-14 | 2011-12-01 | Affectis Pharmaceuticals Ag | Novel P2X7R antagonists and their use |
-
2011
- 2011-03-04 CN CN2011800205646A patent/CN102858741A/zh active Pending
- 2011-03-04 SG SG2012080917A patent/SG185400A1/en unknown
- 2011-03-04 EA EA201201548A patent/EA201201548A1/ru unknown
- 2011-03-04 EP EP11706814A patent/EP2569281A1/en not_active Withdrawn
- 2011-03-04 JP JP2013509476A patent/JP2013526496A/ja not_active Withdrawn
- 2011-03-04 CA CA2799115A patent/CA2799115A1/en not_active Abandoned
- 2011-03-04 AU AU2011252351A patent/AU2011252351A1/en not_active Abandoned
- 2011-03-04 WO PCT/EP2011/053283 patent/WO2011141194A1/en active Application Filing
- 2011-03-04 BR BR112012028850A patent/BR112012028850A2/pt not_active IP Right Cessation
- 2011-03-04 MX MX2012013075A patent/MX2012013075A/es not_active Application Discontinuation
- 2011-03-04 US US13/697,666 patent/US20130060047A1/en not_active Abandoned
- 2011-03-04 EP EP11156932A patent/EP2386541A1/en not_active Withdrawn
-
2012
- 2012-11-08 IL IL222948A patent/IL222948A0/en unknown
- 2012-12-13 ZA ZA2012/09495A patent/ZA201209495B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201209495B (en) | 2013-08-28 |
IL222948A0 (en) | 2012-12-31 |
CN102858741A (zh) | 2013-01-02 |
JP2013526496A (ja) | 2013-06-24 |
EP2569281A1 (en) | 2013-03-20 |
EA201201548A1 (ru) | 2013-05-30 |
WO2011141194A1 (en) | 2011-11-17 |
BR112012028850A2 (pt) | 2015-09-15 |
AU2011252351A1 (en) | 2012-10-11 |
CA2799115A1 (en) | 2011-11-17 |
EP2386541A1 (en) | 2011-11-16 |
US20130060047A1 (en) | 2013-03-07 |
SG185400A1 (en) | 2012-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |