EA201201548A1 - Новые способы получения p2x7r антагонистов - Google Patents

Новые способы получения p2x7r антагонистов

Info

Publication number
EA201201548A1
EA201201548A1 EA201201548A EA201201548A EA201201548A1 EA 201201548 A1 EA201201548 A1 EA 201201548A1 EA 201201548 A EA201201548 A EA 201201548A EA 201201548 A EA201201548 A EA 201201548A EA 201201548 A1 EA201201548 A1 EA 201201548A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new ways
p2x7r antagonists
p2x7r
antagonists
synthesis
Prior art date
Application number
EA201201548A
Other languages
English (en)
Inventor
Михаэль Бёс
Original Assignee
Эффектис Фармасьютиклз Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эффектис Фармасьютиклз Аг filed Critical Эффектис Фармасьютиклз Аг
Publication of EA201201548A1 publication Critical patent/EA201201548A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Описаны новые способы синтеза N-замещенных индол-3-ил-алкиламидных соединений, которые действуют в качестве P2X7R антагонистов, причем указанные способы включают перегруппировку промежуточного оксима.
EA201201548A 2010-05-14 2011-03-04 Новые способы получения p2x7r антагонистов EA201201548A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10162812 2010-05-14
PCT/EP2011/053283 WO2011141194A1 (en) 2010-05-14 2011-03-04 Novel methods for the preparation of p2x7r antagonists

Publications (1)

Publication Number Publication Date
EA201201548A1 true EA201201548A1 (ru) 2013-05-30

Family

ID=43924014

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201201548A EA201201548A1 (ru) 2010-05-14 2011-03-04 Новые способы получения p2x7r антагонистов

Country Status (13)

Country Link
US (1) US20130060047A1 (ru)
EP (2) EP2386541A1 (ru)
JP (1) JP2013526496A (ru)
CN (1) CN102858741A (ru)
AU (1) AU2011252351A1 (ru)
BR (1) BR112012028850A2 (ru)
CA (1) CA2799115A1 (ru)
EA (1) EA201201548A1 (ru)
IL (1) IL222948A0 (ru)
MX (1) MX2012013075A (ru)
SG (1) SG185400A1 (ru)
WO (1) WO2011141194A1 (ru)
ZA (1) ZA201209495B (ru)

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Also Published As

Publication number Publication date
SG185400A1 (en) 2012-12-28
BR112012028850A2 (pt) 2015-09-15
JP2013526496A (ja) 2013-06-24
WO2011141194A1 (en) 2011-11-17
EP2569281A1 (en) 2013-03-20
MX2012013075A (es) 2012-12-17
CA2799115A1 (en) 2011-11-17
ZA201209495B (en) 2013-08-28
US20130060047A1 (en) 2013-03-07
AU2011252351A1 (en) 2012-10-11
EP2386541A1 (en) 2011-11-16
IL222948A0 (en) 2012-12-31
CN102858741A (zh) 2013-01-02

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