BR112014000379A2 - compostos de (trieno[2,3-1)][1,5]benzoxazepin-4-il)piperazin-1-ila como atividade dupla de antagonistas de 5-ht2a /agonistas inversos de h1 - Google Patents

compostos de (trieno[2,3-1)][1,5]benzoxazepin-4-il)piperazin-1-ila como atividade dupla de antagonistas de 5-ht2a /agonistas inversos de h1

Info

Publication number
BR112014000379A2
BR112014000379A2 BR112014000379A BR112014000379A BR112014000379A2 BR 112014000379 A2 BR112014000379 A2 BR 112014000379A2 BR 112014000379 A BR112014000379 A BR 112014000379A BR 112014000379 A BR112014000379 A BR 112014000379A BR 112014000379 A2 BR112014000379 A2 BR 112014000379A2
Authority
BR
Brazil
Prior art keywords
benzoxazepin
piperazin
compounds
triene
inverse agonists
Prior art date
Application number
BR112014000379A
Other languages
English (en)
Inventor
Andrew James Legard
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112014000379A2 publication Critical patent/BR112014000379A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo patente da invenção: "compostos de (trien0[2,3-1)][1,5]benzoxazepin-4-il)piperazin-1-ila como atividade dupla de antagonistas de 5-ht2a /agonistas inversos de h1". são descritos um antagonista de receptor de 5-ht2a /h1 duplo da fórmula: seus usos, e métodos para sua preparação.
BR112014000379A 2011-07-08 2012-07-02 compostos de (trieno[2,3-1)][1,5]benzoxazepin-4-il)piperazin-1-ila como atividade dupla de antagonistas de 5-ht2a /agonistas inversos de h1 BR112014000379A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161505685P 2011-07-08 2011-07-08
PCT/US2012/045254 WO2013009517A1 (en) 2011-07-08 2012-07-02 (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

Publications (1)

Publication Number Publication Date
BR112014000379A2 true BR112014000379A2 (pt) 2017-01-10

Family

ID=46513872

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000379A BR112014000379A2 (pt) 2011-07-08 2012-07-02 compostos de (trieno[2,3-1)][1,5]benzoxazepin-4-il)piperazin-1-ila como atividade dupla de antagonistas de 5-ht2a /agonistas inversos de h1

Country Status (22)

Country Link
US (1) US9481688B2 (pt)
EP (1) EP2729474B1 (pt)
JP (1) JP6050813B2 (pt)
KR (1) KR101582429B1 (pt)
CN (1) CN103703008B (pt)
AU (1) AU2012283035B2 (pt)
BR (1) BR112014000379A2 (pt)
CA (1) CA2840217C (pt)
DK (1) DK2729474T3 (pt)
EA (1) EA023460B1 (pt)
ES (1) ES2665035T3 (pt)
HR (1) HRP20180475T1 (pt)
HU (1) HUE037649T2 (pt)
IN (1) IN2014MN00144A (pt)
LT (1) LT2729474T (pt)
MX (1) MX341132B (pt)
NO (1) NO2729474T3 (pt)
PL (1) PL2729474T3 (pt)
PT (1) PT2729474T (pt)
RS (1) RS57207B1 (pt)
SI (1) SI2729474T1 (pt)
WO (1) WO2013009517A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA026328B1 (ru) 2013-01-14 2017-03-31 Эли Лилли Энд Компани (ТИЕНО[2,3-b][1,5]БЕНЗОКСАЗЕПИН-4-ИЛ)ПИПЕРАЗИН-1-ИЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ АГЕНТОВ С ДВОЙНОЙ АКТИВНОСТЬЮ: ОБРАТНЫХ АГОНИСТОВ Н1/АНТАГОНИСТОВ 5-НТ
TW201625644A (zh) 2014-04-29 2016-07-16 美國禮來大藥廠 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
CN108371660B (zh) * 2017-12-14 2020-03-10 五邑大学 一种四氢环戊二烯并吡咯化合物及其衍生物的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
BR0014447A (pt) * 1999-09-29 2002-06-11 Lilly Co Eli Derivados de piperidina como inibidores da reabsorção
HU226410B1 (en) * 2003-04-22 2008-11-28 Egis Gyogyszergyar Nyilvanosan Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
US7807828B2 (en) 2005-08-11 2010-10-05 Hypnion, Inc. Olanzapine analogs and methods of use thereof
ES2384036T3 (es) * 2007-03-15 2012-06-28 Andaman Therapeutics, Inc. Compuesto de dibenzo[b,f][1,4]oxazapina
MX2010013020A (es) * 2008-05-27 2011-03-21 Intra Cellular Therapies Inc Metodos y composiciones para trastornos del sueño y otros trastornos.
GB0910009D0 (en) * 2009-06-10 2009-07-22 Glaxo Group Ltd Novel compounds
AR084867A1 (es) * 2011-02-07 2013-07-10 Lilly Co Eli Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual
SI2751115T1 (sl) * 2011-08-30 2017-11-30 Eli Lilly And Company SPOJINE (TIENO(2,3-b)(1,5)BENZOKSAZEPIN-4-IL)PIPERAZIN-1-OLA KOT DVOJNO AKTIVNI H1 INVERZNI AGONISTI/5-HT2A ANTAGONISTI

Also Published As

Publication number Publication date
HUE037649T2 (hu) 2018-09-28
EP2729474A1 (en) 2014-05-14
SI2729474T1 (en) 2018-04-30
US20140121199A1 (en) 2014-05-01
HRP20180475T1 (hr) 2018-06-15
CN103703008B (zh) 2015-11-25
JP6050813B2 (ja) 2016-12-21
CA2840217C (en) 2016-03-22
AU2012283035A1 (en) 2014-01-16
NO2729474T3 (pt) 2018-08-11
EA201391706A1 (ru) 2014-04-30
MX2014000337A (es) 2014-11-13
PT2729474T (pt) 2018-06-05
DK2729474T3 (en) 2018-05-22
IN2014MN00144A (pt) 2015-06-19
MX341132B (es) 2016-08-09
KR101582429B1 (ko) 2016-01-04
JP2014518280A (ja) 2014-07-28
WO2013009517A1 (en) 2013-01-17
AU2012283035B2 (en) 2015-07-30
CN103703008A (zh) 2014-04-02
PL2729474T3 (pl) 2018-08-31
CA2840217A1 (en) 2013-01-17
US9481688B2 (en) 2016-11-01
ES2665035T3 (es) 2018-04-24
EP2729474B1 (en) 2018-03-14
EA023460B1 (ru) 2016-06-30
KR20140029512A (ko) 2014-03-10
LT2729474T (lt) 2018-05-10
RS57207B1 (sr) 2018-07-31

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2626 DE 04-05-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.