MA41434A - 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie - Google Patents
7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapieInfo
- Publication number
- MA41434A MA41434A MA041434A MA41434A MA41434A MA 41434 A MA41434 A MA 41434A MA 041434 A MA041434 A MA 041434A MA 41434 A MA41434 A MA 41434A MA 41434 A MA41434 A MA 41434A
- Authority
- MA
- Morocco
- Prior art keywords
- benzyl
- salts
- hexahydroimidazo
- pyrido
- pyrimidin
- Prior art date
Links
- DFULPGUTXZTYKA-UHFFFAOYSA-N 11-benzyl-7-[[4-(trifluoromethyl)phenyl]methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one Chemical compound C(C1=CC=CC=C1)N1CC=2C(N(C=3N(C=2CC1)CCN=3)CC1=CC=C(C=C1)C(F)(F)F)=O DFULPGUTXZTYKA-UHFFFAOYSA-N 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9406—Neurotransmitters
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
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Abstract
La présente invention concerne des méthodes de traitement dans lesquelles on utilise un composé (1) ou ses analogues, et leurs sels pharmaceutiquement acceptables. L'invention concerne également des composés de formule (10) telle que définie dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des compositions pharmaceutiques les comprenant. L'invention concerne également des méthodes de traitement, contre le cancer par exemple, qui consistent à administrer les composés et leurs sels à un sujet nécessitant un tel traitement.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562109737P | 2015-01-30 | 2015-01-30 | |
US201562148844P | 2015-04-17 | 2015-04-17 | |
US201562233757P | 2015-09-28 | 2015-09-28 | |
PCT/US2016/015817 WO2016123571A1 (fr) | 2015-01-30 | 2016-01-29 | 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogues et sels de ce composé et leur utilisation en thérapie |
Publications (2)
Publication Number | Publication Date |
---|---|
MA41434A true MA41434A (fr) | 2017-12-06 |
MA41434B1 MA41434B1 (fr) | 2021-03-31 |
Family
ID=56544438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA055402A MA55402A (fr) | 2015-01-30 | 2016-01-29 | Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie |
MA41434A MA41434B1 (fr) | 2015-01-30 | 2016-01-29 | 7-benzyl-4-(4-(trifluorométhyl)benzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4h)-one, ses sels et leur utilisation en thérapie |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA055402A MA55402A (fr) | 2015-01-30 | 2016-01-29 | Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie |
Country Status (25)
Country | Link |
---|---|
US (4) | US9845324B2 (fr) |
EP (2) | EP3250208B1 (fr) |
JP (2) | JP6802172B2 (fr) |
KR (2) | KR20240005186A (fr) |
CN (2) | CN113149985A (fr) |
AU (4) | AU2016211243B2 (fr) |
BR (1) | BR112017016487B1 (fr) |
CA (3) | CA2975476C (fr) |
CY (1) | CY1123616T1 (fr) |
DK (1) | DK3250208T3 (fr) |
EA (1) | EA037552B1 (fr) |
ES (1) | ES2839401T3 (fr) |
HR (1) | HRP20201949T1 (fr) |
HU (1) | HUE052821T2 (fr) |
IL (4) | IL288525B (fr) |
LT (1) | LT3250208T (fr) |
MA (2) | MA55402A (fr) |
MD (1) | MD3250208T2 (fr) |
MX (3) | MX2021001096A (fr) |
PL (1) | PL3250208T3 (fr) |
PT (1) | PT3250208T (fr) |
RS (1) | RS61243B1 (fr) |
SG (2) | SG10201803508WA (fr) |
SI (1) | SI3250208T1 (fr) |
WO (1) | WO2016123571A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2021001096A (es) | 2015-01-30 | 2023-01-17 | Oncoceutics Inc | 7-bencil-4-(2-metilbencilo)-2,4,6,7,8,9-hexahidroimidazo [1,2-a]pirido[3,4-e]pirimidin-5(1h)-ona, analogos y sales del mismo y su uso en terapia. |
CN104860948B (zh) | 2015-05-15 | 2017-09-26 | 南京盖特医药技术有限公司 | 咪唑并嘧啶酮类化合物及其制备方法和应用 |
BR112018015590A2 (pt) * | 2016-01-29 | 2019-10-01 | Oncoceutics Inc | modulação de receptor acoplado à proteína g (gpcr) por imipridonas |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
JP2019527738A (ja) * | 2016-08-12 | 2019-10-03 | ナンジン ゲイター メディテック カンパニー, リミテッドNanjing Gator Meditech Company, Ltd. | プロテインキナーゼ調節剤 |
US20200129596A1 (en) * | 2017-03-13 | 2020-04-30 | City Of Hope | m6A mRNA MODIFICATION IN CANCER TREATMENT |
WO2019197024A1 (fr) * | 2018-04-11 | 2019-10-17 | Chemestmed Ltd. | Procédé de modulation de la méthylation de l'arn |
JP7364664B2 (ja) | 2019-03-26 | 2023-10-18 | 富士フイルム株式会社 | B型肝炎ウイルスタンパク質の産生を阻害する医薬組成物、b型肝炎を処置するための医薬組成物およびスクリーニング方法 |
CA3190787A1 (fr) * | 2020-08-06 | 2022-02-10 | Eotvos Lorand Tudomanyegyetem | Synthese de nouveaux derives d'imipridone et leur evaluation concernant leur activite anticancereuse |
CN116249538A (zh) | 2020-09-30 | 2023-06-09 | 富士胶片株式会社 | 抑制乙型肝炎病毒蛋白质的产生的双链rna及药物组合物 |
CN113100233B (zh) * | 2021-04-19 | 2022-02-08 | 中国农业科学院植物保护研究所 | 芳甲羟肟酸及其衍生物作为几丁质脱乙酰基酶抑制剂及植物抗真菌剂的应用 |
CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
CN117599041B (zh) * | 2024-01-22 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途 |
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