MD3250208T2 - 7-Benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-onă și sărurile acesteia și utilizarea lor în terapie - Google Patents

7-Benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-onă și sărurile acesteia și utilizarea lor în terapie

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Publication number
MD3250208T2
MD3250208T2 MDE20170317T MDE20170317T MD3250208T2 MD 3250208 T2 MD3250208 T2 MD 3250208T2 MD E20170317 T MDE20170317 T MD E20170317T MD E20170317 T MDE20170317 T MD E20170317T MD 3250208 T2 MD3250208 T2 MD 3250208T2
Authority
MD
Moldova
Prior art keywords
benzyl
salts
hexahydroimidazo
pyrido
pyrimidin
Prior art date
Application number
MDE20170317T
Other languages
English (en)
Inventor
Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Yanjun Sun
Original Assignee
Oncoceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc filed Critical Oncoceutics Inc
Publication of MD3250208T2 publication Critical patent/MD3250208T2/ro

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D487/14—Ortho-condensed systems
    • G—PHYSICS
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Abstract

Această invenţie se referă la metode de tratament utilizând compusul (1) sau analogi ai acestuia şi săruri acceptabile farmaceutic ale acestuia. De asemenea, sunt dezvăluiţi compuşii cu formula (10) aşa cum sunt definiţi în specificaţie, şi sărurile acceptabile farmaceutic ale acestora, precum şi compoziţiile farmaceutice care le conţin. Sunt furnizate metode de tratament, cum ar fi tratamentul cancerului, care cuprind administrarea compuşilor şi a sărurilor acestora unui subiect care are nevoie de un astfel de tratament.
MDE20170317T 2015-01-30 2016-01-29 7-Benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-onă și sărurile acesteia și utilizarea lor în terapie MD3250208T2 (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Publications (1)

Publication Number Publication Date
MD3250208T2 true MD3250208T2 (ro) 2021-02-28

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MDE20170317T MD3250208T2 (ro) 2015-01-30 2016-01-29 7-Benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-onă și sărurile acesteia și utilizarea lor în terapie

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Country Link
US (4) US9845324B2 (ro)
EP (2) EP3805222A3 (ro)
JP (2) JP6802172B2 (ro)
KR (2) KR102618971B1 (ro)
CN (2) CN107427516B8 (ro)
AU (4) AU2016211243B2 (ro)
BR (1) BR112017016487B1 (ro)
CA (3) CA3209515A1 (ro)
CY (1) CY1123616T1 (ro)
DK (1) DK3250208T3 (ro)
EA (1) EA037552B1 (ro)
ES (1) ES2839401T3 (ro)
HR (1) HRP20201949T1 (ro)
HU (1) HUE052821T2 (ro)
IL (4) IL288525B (ro)
LT (1) LT3250208T (ro)
MA (2) MA41434B1 (ro)
MD (1) MD3250208T2 (ro)
MX (3) MX2017009841A (ro)
PL (1) PL3250208T3 (ro)
PT (1) PT3250208T (ro)
RS (1) RS61243B1 (ro)
SG (2) SG10201803508WA (ro)
SI (1) SI3250208T1 (ro)
WO (1) WO2016123571A1 (ro)

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