MD3484467T2 - Combinație de antagoniști ai receptorilor 5-HT6 puri cu inhibitori ai acetilcolinesterazei - Google Patents
Combinație de antagoniști ai receptorilor 5-HT6 puri cu inhibitori ai acetilcolinesterazeiInfo
- Publication number
- MD3484467T2 MD3484467T2 MDE20190594T MDE20190594T MD3484467T2 MD 3484467 T2 MD3484467 T2 MD 3484467T2 MD E20190594 T MDE20190594 T MD E20190594T MD E20190594 T MDE20190594 T MD E20190594T MD 3484467 T2 MD3484467 T2 MD 3484467T2
- Authority
- MD
- Moldova
- Prior art keywords
- combination
- pure
- receptor antagonists
- acetylcholinesterase inhibitors
- relates
- Prior art date
Links
- 108091005435 5-HT6 receptors Proteins 0.000 title abstract 2
- 239000000544 cholinesterase inhibitor Substances 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Abstract
Prezenta invenţie se referă la antagonişti ai receptorilor 5-HT6 puri (5-HT6R) sau la sărurile lor acceptabile farmaceutic în combinaţie cu sau pe lângă inhibitorii acetilcolinesterazei şi la utilizarea acestora în tratarea bolilor cognitive. Invenţia se referă de asemenea la compoziţia farmaceutică ce conţine combinaţia respectivă.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201641017205 | 2016-05-18 | ||
| PCT/IB2016/054673 WO2017199071A1 (en) | 2016-05-18 | 2016-08-03 | Combination of pure 5-ht6 receptor antagonists with acetylcholinesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3484467T2 true MD3484467T2 (ro) | 2020-06-30 |
Family
ID=56940098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20190594T MD3484467T2 (ro) | 2016-05-18 | 2016-08-03 | Combinație de antagoniști ai receptorilor 5-HT6 puri cu inhibitori ai acetilcolinesterazei |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US11458135B2 (ro) |
| EP (1) | EP3484467B1 (ro) |
| JP (1) | JP6606299B2 (ro) |
| KR (1) | KR102015484B1 (ro) |
| CN (2) | CN114642667A (ro) |
| AU (1) | AU2016407427B2 (ro) |
| BR (1) | BR112018073419A2 (ro) |
| CA (1) | CA3023819C (ro) |
| CY (1) | CY1123013T1 (ro) |
| DK (1) | DK3484467T3 (ro) |
| EA (1) | EA036347B1 (ro) |
| ES (1) | ES2796181T3 (ro) |
| HR (1) | HRP20200872T1 (ro) |
| HU (1) | HUE050819T2 (ro) |
| IL (1) | IL262921B (ro) |
| LT (1) | LT3484467T (ro) |
| MA (1) | MA45639B1 (ro) |
| MD (1) | MD3484467T2 (ro) |
| ME (1) | ME03731B (ro) |
| MX (1) | MX2018014185A (ro) |
| NZ (1) | NZ748280A (ro) |
| PL (1) | PL3484467T3 (ro) |
| PT (1) | PT3484467T (ro) |
| RS (1) | RS60422B1 (ro) |
| SG (1) | SG11201809856SA (ro) |
| SI (1) | SI3484467T1 (ro) |
| WO (1) | WO2017199071A1 (ro) |
| ZA (1) | ZA201807468B (ro) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111084768A (zh) * | 2018-10-24 | 2020-05-01 | 中国科学院昆明动物研究所 | 吉非罗齐及其衍生物用于治疗和/或预防神经退行性疾病的用途 |
| CN111084776A (zh) * | 2018-10-24 | 2020-05-01 | 中国科学院昆明动物研究所 | 匹立尼酸及其衍生物用于治疗和/或预防神经退行性疾病的用途 |
| JP2023506724A (ja) * | 2019-12-02 | 2023-02-20 | スヴェン・ライフ・サイエンシーズ・リミテッド | 認知症患者の行動心理学的症状の治療 |
| CA3162938A1 (en) * | 2019-12-02 | 2021-06-10 | Suven Life Sciences Limited | Methods for treating behavioral and psychological symptoms in patients with dementia |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4559230B2 (ja) * | 2002-11-28 | 2010-10-06 | スベン ライフ サイエンシズ リミティド | セロトニン受容体に対する親和性を有する新規ｎ−アリールスルホニル−３−置換されたインドール、その調製方法、それを含有する医薬組成物 |
| PE20071143A1 (es) | 2006-01-13 | 2008-01-20 | Wyeth Corp | Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 |
| ES2366958T3 (es) * | 2006-06-23 | 2011-10-27 | Laboratorios Del Dr. Esteve, S.A. | Combinación de un inhibidor de la colinesterasa y un compuesto con afinidad por el receptor 5-ht6. |
| AR061637A1 (es) | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| CA2929309C (en) * | 2013-12-02 | 2018-07-03 | Suven Life Sciences Limited | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate |
-
2016
- 2016-08-03 KR KR1020187035983A patent/KR102015484B1/ko active IP Right Grant
- 2016-08-03 CN CN202210321209.2A patent/CN114642667A/zh active Pending
- 2016-08-03 NZ NZ748280A patent/NZ748280A/en unknown
- 2016-08-03 AU AU2016407427A patent/AU2016407427B2/en active Active
- 2016-08-03 ES ES16766622T patent/ES2796181T3/es active Active
- 2016-08-03 BR BR112018073419-5A patent/BR112018073419A2/pt not_active Application Discontinuation
- 2016-08-03 MA MA45639A patent/MA45639B1/fr unknown
- 2016-08-03 PL PL16766622T patent/PL3484467T3/pl unknown
- 2016-08-03 CA CA3023819A patent/CA3023819C/en active Active
- 2016-08-03 ME MEP-2020-109A patent/ME03731B/me unknown
- 2016-08-03 RS RS20200635A patent/RS60422B1/sr unknown
- 2016-08-03 SI SI201630791T patent/SI3484467T1/sl unknown
- 2016-08-03 SG SG11201809856SA patent/SG11201809856SA/en unknown
- 2016-08-03 US US16/099,161 patent/US11458135B2/en active Active
- 2016-08-03 JP JP2018559336A patent/JP6606299B2/ja active Active
- 2016-08-03 EP EP16766622.1A patent/EP3484467B1/en active Active
- 2016-08-03 WO PCT/IB2016/054673 patent/WO2017199071A1/en unknown
- 2016-08-03 EA EA201892529A patent/EA036347B1/ru unknown
- 2016-08-03 HU HUE16766622A patent/HUE050819T2/hu unknown
- 2016-08-03 LT LTEP16766622.1T patent/LT3484467T/lt unknown
- 2016-08-03 PT PT167666221T patent/PT3484467T/pt unknown
- 2016-08-03 DK DK16766622.1T patent/DK3484467T3/da active
- 2016-08-03 CN CN201680085574.0A patent/CN109069468A/zh active Pending
- 2016-08-03 MX MX2018014185A patent/MX2018014185A/es unknown
- 2016-08-03 MD MDE20190594T patent/MD3484467T2/ro unknown
-
2018
- 2018-11-07 ZA ZA2018/07468A patent/ZA201807468B/en unknown
- 2018-11-11 IL IL262921A patent/IL262921B/en active IP Right Grant
-
2020
- 2020-05-29 CY CY20201100489T patent/CY1123013T1/el unknown
- 2020-06-02 HR HRP20200872TT patent/HRP20200872T1/hr unknown
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