PE20071143A1 - Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 - Google Patents

Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6

Info

Publication number
PE20071143A1
PE20071143A1 PE2006001716A PE2006001716A PE20071143A1 PE 20071143 A1 PE20071143 A1 PE 20071143A1 PE 2006001716 A PE2006001716 A PE 2006001716A PE 2006001716 A PE2006001716 A PE 2006001716A PE 20071143 A1 PE20071143 A1 PE 20071143A1
Authority
PE
Peru
Prior art keywords
hydroxitriptamine
antagonist
pharmaceutical composition
composition including
acetylcholinesterase inhibitor
Prior art date
Application number
PE2006001716A
Other languages
English (en)
Inventor
Thomas Anthony Comery
Lee Erwin Schechter
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20071143A1 publication Critical patent/PE20071143A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A)UN INHIBIDOR DE ACETILCOLINESTERASA SELECCIONADO DE DONEPEZIL, GALANTAMINA Y RIVASTIGMINA; Y B) UN ANTAGONISTA 5-HIDROXITRIPTAMINA-6 DE FORMULA (I), EN DONDE R1 ES -W(CR5R6)nNR7R8, a), ENTRE OTROS, DONDE W ES O, S, NR, ENTRE OTROS; R2 ES H, HALOGENO, CN, OR12, CO2R17, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R4 ES ARILO, HETEROARILO O UN ANILLO BI O TRICICLICO DE 8 A 13 MIEMBROS, SIENDO SELECCIONADOS: 3-(1-NAFTILSULFONIL)-5-PIPERAZIN-1-IL-1H-INDAZOL, 1,1-DIMETIL-3-{[3-(1-NAFTILSULFONIL)-1H-INDAZOL-5-IL]OXI}PROPAN-1-AMINA, ENTRE OTROS. DICHA COMPOSICION PUEDE ADMINISTRARSE EN FORMA SIMULTANEA, SEPARADA O SECUENCIAL, SIENDO UTIL EN EL TRATAMIENTO DE TRASTORNO COGNOCITIVO, TAL COMO LA ENFERMEDAD DE ALZHEIMER
PE2006001716A 2006-01-13 2006-12-28 Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6 PE20071143A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75884106P 2006-01-13 2006-01-13

Publications (1)

Publication Number Publication Date
PE20071143A1 true PE20071143A1 (es) 2008-01-20

Family

ID=38109582

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001716A PE20071143A1 (es) 2006-01-13 2006-12-28 Composicion farmaceutica que comprende un inhibidor de acetilcolinesterasa y un antagonista 5-hidroxitriptamina-6

Country Status (20)

Country Link
US (1) US20070167431A1 (es)
EP (1) EP1971334A2 (es)
JP (1) JP2009523728A (es)
KR (1) KR20080096657A (es)
CN (1) CN101370499A (es)
AR (1) AR060019A1 (es)
AU (1) AU2007208516A1 (es)
BR (1) BRPI0706515A2 (es)
CA (1) CA2635920A1 (es)
CR (1) CR10139A (es)
EC (1) ECSP088619A (es)
GT (1) GT200800138A (es)
IL (1) IL192694A0 (es)
MX (1) MX2008009021A (es)
NO (1) NO20082894L (es)
PE (1) PE20071143A1 (es)
RU (1) RU2008126245A (es)
TW (1) TW200733976A (es)
WO (1) WO2007087151A2 (es)
ZA (1) ZA200806070B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1558582E (pt) 2003-07-22 2006-05-31 Arena Pharm Inc Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
MX2008015996A (es) * 2006-06-23 2009-01-20 Esteve Labor Dr Combinacion de un inhibidor de la colinesterasa y un compuesto con afinidad por el receptor 5-ht6.
AR061637A1 (es) * 2006-06-26 2008-09-10 Epix Delaware Inc Composiciones y metodos de tratamiento de trastornos del snc
EP2254564A1 (en) 2007-12-12 2010-12-01 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
US20110021538A1 (en) 2008-04-02 2011-01-27 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
RU2467749C1 (ru) * 2011-04-21 2012-11-27 Государственное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации Способ коррекции уровня сахара крови и лечения пациентов с сахарным диабетом второго типа с когнитивными нарушениями
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
AU2015341913B2 (en) * 2014-11-03 2020-07-16 Iomet Pharma Ltd Pharmaceutical compound
JP2018515607A (ja) * 2015-05-07 2018-06-14 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ 神経変性疾患を処置する組成物および方法
RU2017145976A (ru) 2015-06-12 2019-07-15 Аксовант Сайенсиз Гмбх Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна
KR20180064373A (ko) 2015-07-15 2018-06-14 엑소반트 사이언시즈 게엠베하 신경퇴행성 질환과 관련된 환각의 예방 및 치료에 유용한 5-ht2a 세로토닌 수용체의 조절자로서의 다이아릴 및 아릴헤테로아릴 우레아 유도체
WO2017147601A1 (en) * 2016-02-25 2017-08-31 Axovant Sciences Gmbh Methods of improving balance, gait or both in patients with neurological disease
BR112017026928B1 (pt) * 2016-04-26 2023-04-11 H. Lundbeck A/S Uso de idalopirdina em combinação com um inibidor de acetilcolinesterase
US10864191B2 (en) * 2016-05-11 2020-12-15 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity
EA036347B1 (ru) * 2016-05-18 2020-10-29 Сувен Лайф Сайенсиз Лимитед Комбинация чистых антагонистов 5-ht6 рецепторов с ингибиторами ацетилхолинэстеразы

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005102A (en) * 2000-11-02 2002-05-15 Wyeth Corp 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
BR0317110A (pt) * 2002-12-11 2005-10-25 Pharmacia & Upjohn Co Llc Tratamento de doenças com combinações de agonistas do receptor nicotìnico da acetilcolina alfa 7 e outros compostos
RU2347780C2 (ru) * 2003-02-14 2009-02-27 Уайт Гетероциклил-3-сульфонилиндазолы в качестве лигандов 5-гидрокситриптамина-6
EP1931640A2 (en) * 2005-08-15 2008-06-18 Wyeth a Corporation of the State of Delaware Substituted-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands

Also Published As

Publication number Publication date
ECSP088619A (es) 2008-08-29
NO20082894L (no) 2008-09-30
WO2007087151A3 (en) 2007-11-15
EP1971334A2 (en) 2008-09-24
GT200800138A (es) 2008-10-06
IL192694A0 (en) 2009-02-11
TW200733976A (en) 2007-09-16
WO2007087151A2 (en) 2007-08-02
AU2007208516A8 (en) 2008-08-07
CR10139A (es) 2008-09-30
BRPI0706515A2 (pt) 2011-03-29
CA2635920A1 (en) 2007-08-02
RU2008126245A (ru) 2010-02-20
CN101370499A (zh) 2009-02-18
MX2008009021A (es) 2008-09-24
KR20080096657A (ko) 2008-10-31
AU2007208516A1 (en) 2007-08-02
AR060019A1 (es) 2008-05-21
JP2009523728A (ja) 2009-06-25
US20070167431A1 (en) 2007-07-19
ZA200806070B (en) 2009-04-29

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