ATE425166T1 - Amidderivate von 3-phenyldihydropyrimidoä4,5- düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel - Google Patents
Amidderivate von 3-phenyldihydropyrimidoä4,5- düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittelInfo
- Publication number
- ATE425166T1 ATE425166T1 AT05779393T AT05779393T ATE425166T1 AT E425166 T1 ATE425166 T1 AT E425166T1 AT 05779393 T AT05779393 T AT 05779393T AT 05779393 T AT05779393 T AT 05779393T AT E425166 T1 ATE425166 T1 AT E425166T1
- Authority
- AT
- Austria
- Prior art keywords
- amide derivatives
- düpyrimidinones
- preparation
- pharmaceutical agents
- manufacture
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- -1 amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04020598 | 2004-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425166T1 true ATE425166T1 (de) | 2009-03-15 |
Family
ID=34926359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05779393T ATE425166T1 (de) | 2004-08-31 | 2005-08-30 | Amidderivate von 3-phenyldihydropyrimidoä4,5- düpyrimidinonen, deren herstellung und verwendung als pharmazeutische mittel |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7655651B2 (de) |
| EP (1) | EP1789416B1 (de) |
| JP (1) | JP2008510690A (de) |
| KR (1) | KR100853975B1 (de) |
| CN (1) | CN1980933B (de) |
| AT (1) | ATE425166T1 (de) |
| AU (1) | AU2005279336A1 (de) |
| BR (1) | BRPI0514738A (de) |
| CA (1) | CA2576818A1 (de) |
| DE (1) | DE602005013248D1 (de) |
| ES (1) | ES2320570T3 (de) |
| MX (1) | MX2007002096A (de) |
| RU (1) | RU2007111757A (de) |
| WO (1) | WO2006024486A2 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1860118A (zh) * | 2003-07-29 | 2006-11-08 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| TW200835497A (en) * | 2007-01-11 | 2008-09-01 | Astrazeneca Ab | Chemical compounds 636 |
| SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| UA125503C2 (uk) | 2012-06-13 | 2022-04-13 | Інсайт Холдинґс Корпорейшн | Заміщені трициклічні сполуки як інгібітори fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| SG11201507478VA (en) | 2013-03-15 | 2015-10-29 | Celgene Avilomics Res Inc | Heteroaryl compounds and uses thereof |
| MY181020A (en) | 2013-03-15 | 2020-12-16 | Sanofi Sa | Heteroaryl compounds and uses thereof |
| MY181497A (en) | 2013-04-19 | 2020-12-23 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CR20170390A (es) | 2015-02-20 | 2017-10-23 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de fgfr |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| CA3069016A1 (en) | 2016-07-05 | 2018-01-11 | The Broad Institute, Inc. | Bicyclic urea kinase inhibitors and uses thereof |
| KR101818130B1 (ko) | 2016-08-09 | 2018-01-12 | 한국과학기술연구원 | 1,3,7-삼치환된 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 유도체가 포함된 급성골수성백혈병 치료제 |
| KR101897631B1 (ko) * | 2016-08-10 | 2018-09-12 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 골격의 유레아 화합물 |
| AU2018226771B2 (en) | 2017-02-28 | 2023-11-23 | Dana-Farber Cancer Institute, Inc. | Uses of pyrimidopyrimidinones as SIK inhibitors |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN109836427B (zh) * | 2017-11-29 | 2022-04-15 | 暨南大学 | 嘧啶并嘧啶酮类化合物及其应用 |
| PE20210919A1 (es) | 2018-05-04 | 2021-05-19 | Incyte Corp | Sales de un inhibidor de fgfr |
| BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
| CN108610343A (zh) * | 2018-06-12 | 2018-10-02 | 杨文思 | 一种用于治疗癌症的表皮生长因子受体抑制剂及其合成方法 |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| GEP20247679B (en) | 2019-10-14 | 2024-10-10 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| PE20221504A1 (es) | 2019-12-04 | 2022-09-30 | Incyte Corp | Derivados de un inhibidor de fgfr |
| KR102382613B1 (ko) * | 2020-01-15 | 2022-04-06 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물 |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| KR102673031B1 (ko) | 2020-09-16 | 2024-06-07 | 주식회사 엑세쏘바이오파마 | 피리미도 피리미디논 화합물 및 그를 포함하는 약제학적 조성물 |
| TW202304459A (zh) | 2021-04-12 | 2023-02-01 | 美商英塞特公司 | 包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法 |
| TW202313611A (zh) | 2021-06-09 | 2023-04-01 | 美商英塞特公司 | 作為ｆｇｆｒ抑制劑之三環雜環 |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| US20240352021A1 (en) * | 2021-10-18 | 2024-10-24 | Dana-Farber Cancer Institute, Inc. | Covalent egfr inhibitors and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200000706A (et) | 1998-05-26 | 2002-06-17 | Warner-Lambert Company | Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid |
| EP1123295B1 (de) * | 1998-10-23 | 2004-09-29 | F. Hoffmann-La Roche Ag | Bicyclische stickstoffheteroaryl verbindungen |
| EP1226144B1 (de) | 1999-10-21 | 2006-12-27 | F. Hoffmann-La Roche Ag | Alkylamino-substituierte bicyclische heterocyclen als p38 protein kinase inhibitoren |
| CZ20021744A3 (cs) | 1999-10-21 | 2002-08-14 | F. Hoffmann-La Roche Ag | Bicyklické dusíkové heterocykly substituované heteroalkylaminoskupinou jako inhibitory P38 proteinkinázy |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| US7084270B2 (en) | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| TW200413381A (en) * | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| US7129351B2 (en) * | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| CN1860118A (zh) | 2003-07-29 | 2006-11-08 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
-
2005
- 2005-08-30 DE DE602005013248T patent/DE602005013248D1/de not_active Expired - Lifetime
- 2005-08-30 RU RU2007111757/04A patent/RU2007111757A/ru not_active Application Discontinuation
- 2005-08-30 BR BRPI0514738-7A patent/BRPI0514738A/pt not_active IP Right Cessation
- 2005-08-30 CA CA002576818A patent/CA2576818A1/en not_active Abandoned
- 2005-08-30 CN CN2005800222383A patent/CN1980933B/zh not_active Expired - Fee Related
- 2005-08-30 KR KR1020077004516A patent/KR100853975B1/ko not_active Expired - Fee Related
- 2005-08-30 WO PCT/EP2005/009321 patent/WO2006024486A2/en not_active Ceased
- 2005-08-30 EP EP05779393A patent/EP1789416B1/de not_active Expired - Lifetime
- 2005-08-30 ES ES05779393T patent/ES2320570T3/es not_active Expired - Lifetime
- 2005-08-30 MX MX2007002096A patent/MX2007002096A/es active IP Right Grant
- 2005-08-30 US US11/660,198 patent/US7655651B2/en not_active Expired - Fee Related
- 2005-08-30 AU AU2005279336A patent/AU2005279336A1/en not_active Abandoned
- 2005-08-30 AT AT05779393T patent/ATE425166T1/de active
- 2005-08-30 JP JP2007526401A patent/JP2008510690A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008510690A (ja) | 2008-04-10 |
| AU2005279336A1 (en) | 2006-03-09 |
| KR100853975B1 (ko) | 2008-08-25 |
| MX2007002096A (es) | 2007-03-29 |
| WO2006024486A3 (en) | 2006-05-26 |
| WO2006024486A2 (en) | 2006-03-09 |
| DE602005013248D1 (de) | 2009-04-23 |
| EP1789416A2 (de) | 2007-05-30 |
| CA2576818A1 (en) | 2006-03-09 |
| EP1789416B1 (de) | 2009-03-11 |
| CN1980933A (zh) | 2007-06-13 |
| ES2320570T3 (es) | 2009-05-25 |
| US20070232611A1 (en) | 2007-10-04 |
| CN1980933B (zh) | 2010-07-14 |
| BRPI0514738A (pt) | 2008-06-24 |
| RU2007111757A (ru) | 2008-10-10 |
| KR20070039606A (ko) | 2007-04-12 |
| US7655651B2 (en) | 2010-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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