AR054632A1 - ANALOGOS DE PIRIDINA, COMPOSICIONES QUE LOS CONTIENEN Y PROCESOS PARA SU PREPARACIoN - Google Patents
ANALOGOS DE PIRIDINA, COMPOSICIONES QUE LOS CONTIENEN Y PROCESOS PARA SU PREPARACIoNInfo
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- AR054632A1 AR054632A1 ARP060102992A ARP060102992A AR054632A1 AR 054632 A1 AR054632 A1 AR 054632A1 AR P060102992 A ARP060102992 A AR P060102992A AR P060102992 A ARP060102992 A AR P060102992A AR 054632 A1 AR054632 A1 AR 054632A1
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- cycloalkyl
- heterocyclyl
- alkyl
- aryl
- alkylthio
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Utiles como medicamentos en enfermedades cardiovasculares como así también a composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto de formula (1) o una sal aceptable para uso farmacéutico del mismo: donde R1 representa R6OC(O), R7C(O), R16SC(O), R17S, R18C(S) o un grupo de formula (2), R2 representa H, CN, halogeno (F, Cl, Br, I), NO2, alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I); además R2 representa alcoxi C1-12 opcionalmente sustituido con uno o más átomos de halogeno (F, Cl, Br, I); además R2 representa cicloalquilo C3-6, hidroxialquilo C1-12, alquil C1-12C(O), alquiltio C1-12C(O), alquil C1-12C(S), alcoxi C1-12C(O), cicloalcoxi C3-6, arilo, arilC(O), arilalquil C1-12C(O), heterociclilo, heterociclilC(O), heterociclilalquil C1-12C(O), alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, arilalquilsulfinilo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, heterociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3-6alquiltio C1-12, cicloalquil C3-6 alquilsulfinilo C1-12, cicloalquil C3-6alquilsulfonilo C1-12, o un grupo de formula NRa(2)Rb(2) donde Ra(2) y Rb(2) representan en forma independiente H, alquilo C1-12, alquil C1-12C(O) o Ra(2) y Rb(2) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; además, R1 + R2 juntos (con dos átomos de carbono del anillo de piridina) pueden formar una lactona cíclica de 5 o 6 miembros; R3 representa H, CN, NO2, halogeno (F, CI, Br, I), alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I); además R3 representa alcoxi C1-12 opcionalmente sustituido con uno o más átomos de halogeno (F, CI, Br, I); además R3 representa cicloalquilo C3-6, hidroxialquilo C1-12, alquil C1-12C(O), alquiltio C1-12C(O), alquil C1-12C(S), alcoxi C1-12C(O), cicloalcoxi C3-6, arilo, arilC(O), arilalquil C1-12C(O), heterociclilo, heterociclilC(O), heterociclilalquil C1-12C(O), alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, arilalquilsulfinilo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, heterociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3-6alquiltio C1-12, cicloalquil C3-6alquilsulfinilo C1-12, cicloalquil C3-6alquilsulfonilo C1-12 o un grupo de formula NRa(3)Rb(3) donde Ra(3) y Rb(3) representan en forma independiente H, alquilo C1-12, alquil C1-12C(O) o Ra(3) y Rb(3) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; R4 representa H, CN, NO2, halogeno (F, CI, Br, I), alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, COOH, alcoxicarbonilo C1-6, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I); además R4 representa cicloalquilo C3-6, hidroxialquilo C1-12, alquil C1-12C(O), alquilcicloalquilo C1-12, alcoxi C1-12 donde el grupo alcoxi puede estar opcionalmente sustituido con uno o más átomos de halogeno (F, CI, Br, I), OH y/o COOH y/o alcoxicarbonilo C1-6; además R4 representa alquiltio C1-12C(O), alquil C1-12C(S), alcoxi C1-12C(O), cicloalcoxi C3-6, arilo, arilC(O), arilalquil C1-12C(O), heterociclilo, heterociclilC(O), heterociclilalquil C1-12C(O), alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, ariIalquilsuIfinilo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, heterociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3- 6alquiltio C1-12, cicloalquil C3-6alquilsulfinilo C1-12, cicloalquil C3-6alquilsulfonilo C1-12 o un grupo de formula NRa(4)Rb(4) donde Ra(4) y Rb(4) representan en forma independiente H, alquilo C1-12, alquil C1-12C(O) o Ra(4) y Rb(4) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; Z representa O o esta ausente; R5 representa H o alquilo C1-12; R6 representa alquilo C1-12 opcionalmente interrumpido por oxígeno, (con la condicion de que cualquier oxígeno debe estar al menos a 2 átomos de carbono de distancia del oxígeno del éster que conecta el grupo R6) y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I); además R6 representa cicloalquilo C3-6, hidroxialquilo C2-12, arilo o heterociclilo; R7 representa alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I), además R7 representa cicloalquilo C3-6, hidroxialquilo C1-12, arilo o heterociclilo; R8 representa H, alquilo C1-12 opcionalmente interrumpido con oxígeno y/u opcionalmente sustituido con arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, C, Br, I); además R8 representa cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo, heterociclilo, alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, ariIalquilsulfiniIo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, heterociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3-6alquiltio, C1-12, cicloalquil C3- 6alquilsulfinilo C1-12 o cicloalquil C3-6alquilsulfonilo C1-12; R14 representa H, OH con la condicion de que el grupo OH debe estar al menos a 2 átomos de carbono de distancia de cualquier heteroátomo en el anillo/sistema anular B, alquilo C1-12 opcionalmente interrumpido por oxígeno, y/u opcionalmente sustituido con uno o más de OH, COOH y COORe; donde Re representa arilo, cicloalquilo, heterociclilo o alquilo C1-12 opcionalmente sustituido con uno o más átomos de halogeno (F, CI, Br, I), OH, arilo, cicloalquilo y heterociclilo; además R14 representa arilo, heterociclilo, uno o más átomos de halogeno (F, CI, Br, I), cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo, heterociclilo, alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, arilalquilsulfinilo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, heterociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3-6alquiltio C1-12, cicloalquil C3-6alquilsulfinilo C1-12 o cicloalquil C3-6alquilsulfonilo C1-12, un grupo de formula Ra(14) y Rb(14) donde Ra(14) y Rb(14) representan en forma independiente H, alquilo C1-12, alquil C1-12C(O), alcoxi C1-12C(O) o Ra(14) y Rb(14) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; R15 representa H, OH con la condicion de que el grupo OH debe estar al menos a 2 átomos de carbono de distancia de cualquier heteroátomo en el anillo/sistema anular B, alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con uno o más de OH, COOH y COORe; donde Re representa arilo, cicloalquilo, heterociclilo o alquilo opcionalmente sustituido con uno o más átomos de halogeno (F, CI, Br, I), OH, arilo, cicloalquilo y heterociclilo; además R15 representa arilo, heterociclilo, uno o más átomos de halogeno (F, CI, Br, I), cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo, heterociclilo, alquilsulfinilo C1-12, alquilsulfonilo C1-12, alquiltio C1-12, cicloalquiltio C3-6, arilsulfinilo, arilsulfonilo, ariltio, arilalquiltio C1-12, arilalquilsulfinilo C1-12, arilalquilsulfonilo C1-12, heterociclilalquiltio C1-12, helerociclilalquilsulfinilo C1-12, heterociclilalquilsulfonilo C1-12, cicloalquil C3-6alquiltio C1-12, cicloalquil C3-6alquilsulfinilo C1-12, cicloalquil C3-6alquilsulfonilo C1-12 o un grupo de formula NRa(15)Rb(15) donde Ra(15) y Rb(15) representan en forma independiente H, alquilo C1-12, alquil C1-12C(O), alcoxi (C1-12C(O) o Ra(15) y Rb(15) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; R16 representa alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I), además R16 representa cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo o heterociclilo; R17 representa alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I), además R17 representa cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo o heterociclilo; R18 representa alquilo C1-12 opcionalmente interrumpido por oxígeno y/u opcionalmente sustituido con OH, arilo, cicloalquilo, heterociclilo o uno o más átomos de halogeno (F, CI, Br, I), además R18 representa cicloalquilo C3-6, hidroxialquilo C1-12, alcoxi C1-12, cicloalcoxi C3-6, arilo o heterociclilo; Rc representa un grupo alquileno C1-4, un grupo oxoaIquileno C1-4, un grupo alquilenoxi C1-4 o un grupo oxialquileno C1-4 no sustituido o monosustituido o polisustituido, donde cualquiera de los sustituyentes se seleccionan cada uno en forma individual e independiente de alquilo C1-4, alcoxilo C1-4, oxialquilo C1-4, alquenilo C2-4, alquinilo C2-4, cicloalquilo C3-6, carboxilo, carboxialquilo C1-4, arilo, heterociclilo, nitro, ciano, halogeno (F, CI, Br, I), hidroxilo, NRa(Rc)Rb(Rc) donde Ra(Rc) y Rb(Rc) en forma individual e independiente entre sí representan hidrogeno, alquilo C1-4 o Ra(Rc) y Rb(Rc) junto con el átomo de nitrogeno representan piperidina, pirrolidina, azetidina o aziridina; además Rc representa imino (-NH-), imino
Applications Claiming Priority (2)
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SE0501663 | 2005-07-13 | ||
SE0502354 | 2005-10-24 |
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AR054632A1 true AR054632A1 (es) | 2007-07-04 |
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ARP060102992A AR054632A1 (es) | 2005-07-13 | 2006-07-12 | ANALOGOS DE PIRIDINA, COMPOSICIONES QUE LOS CONTIENEN Y PROCESOS PARA SU PREPARACIoN |
Country Status (15)
Country | Link |
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US (1) | US20080312208A1 (es) |
EP (1) | EP1904474A4 (es) |
JP (1) | JP2009501216A (es) |
KR (1) | KR20080039405A (es) |
AR (1) | AR054632A1 (es) |
AU (1) | AU2006267148A1 (es) |
CA (1) | CA2614726A1 (es) |
EC (1) | ECSP088140A (es) |
IL (1) | IL188293A0 (es) |
MX (1) | MX2008000470A (es) |
NO (1) | NO20076682L (es) |
RU (1) | RU2008101924A (es) |
TW (1) | TW200726758A (es) |
UY (1) | UY29667A1 (es) |
WO (1) | WO2007008140A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080009523A1 (en) * | 2006-07-04 | 2008-01-10 | Astrazeneca Ab | New Pyridine Analogues IV |
US20080027103A1 (en) * | 2006-07-04 | 2008-01-31 | Astrazeneca Ab | Novel Crystalline Forms 1 |
US20080200448A1 (en) * | 2007-01-12 | 2008-08-21 | Astrazeneca Ab | New Pyridine Analogues VIII 518 |
UY30867A1 (es) * | 2007-01-12 | 2008-09-02 | Astrazeneca Ab | Nuevos analogos de piridina vii 543 |
BRPI0806529A2 (pt) * | 2007-01-12 | 2014-04-22 | Astrazeneca Ab | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, e, método de tratamento de um distúrbio de agregação de plaqueta |
CL2008000090A1 (es) * | 2007-07-13 | 2009-01-16 | Astrazeneca Ab | Compuestos derivados de piridina; composicion farmaceutica que comprende a dichos compuestos; y su uso como inhibidores del receptor p2y 12 para tratar un trastorno de agragacion de plaquetas. |
AR074628A1 (es) * | 2008-07-07 | 2011-02-02 | Astrazeneca Ab | Derivados de piridina 2- amino-6-alquil sustituidos utiles como inhibidores de p2y12 308 |
AR072697A1 (es) * | 2008-07-07 | 2010-09-15 | Astrazeneca Ab | Compuestos de piridina, composiciones farmaceuticas que los contienen y su uso en el tratamiento de trastorno de agregacion plaquetaria |
JP2014051434A (ja) * | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
EP2750676B1 (en) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
CN103483274B (zh) * | 2013-09-25 | 2016-03-09 | 江苏快达农化股份有限公司 | 一种制备苄嘧磺隆的方法 |
WO2017022861A1 (ja) | 2015-08-06 | 2017-02-09 | 宇部興産株式会社 | 置換グアニジン誘導体 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US6156758A (en) * | 1999-09-08 | 2000-12-05 | Isis Pharmaceuticals, Inc. | Antibacterial quinazoline compounds |
ATE309999T1 (de) * | 2000-02-04 | 2005-12-15 | Portola Pharm Inc | Blutplättchen-adp-rezeptor-inhibitoren |
US6906063B2 (en) * | 2000-02-04 | 2005-06-14 | Portola Pharmaceuticals, Inc. | Platelet ADP receptor inhibitors |
US7018985B1 (en) * | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US7132408B2 (en) * | 2000-08-21 | 2006-11-07 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
US7452870B2 (en) * | 2000-08-21 | 2008-11-18 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with P2Y12 receptor antagonist compound |
FR2820057A1 (fr) * | 2001-01-30 | 2002-08-02 | Ct De Transfert De Technologie | Membrane pour chambre d'encapsulation de cellules produisant au moins une substance biologiquement active et organe bio-artificiel comprenant une telle membrane |
AR037097A1 (es) * | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
CN1319967C (zh) * | 2002-01-18 | 2007-06-06 | 安斯泰来制药有限公司 | 2-酰基氨基噻唑衍生物或其盐 |
GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
AU2004279809B2 (en) * | 2003-10-03 | 2010-07-15 | Portola Pharmaceuticals, Inc. | Substituted isoquinolinones |
US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
US7335648B2 (en) * | 2003-10-21 | 2008-02-26 | Inspire Pharmaceuticals, Inc. | Non-nucleotide composition and method for inhibiting platelet aggregation |
US7749981B2 (en) * | 2003-10-21 | 2010-07-06 | Inspire Pharmaceuticals, Inc. | Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound |
WO2005056354A2 (en) * | 2003-12-03 | 2005-06-23 | Gedeon Anthony A | Method of resisting contaminant build up and oxidation of vehicle surfaces and other surfaces |
BRPI0512535A (pt) * | 2004-06-24 | 2008-03-25 | Incyte Corp | compostos de piperidinas n-substituìdas, suas composições e métodos de modulações |
MX2007008237A (es) * | 2005-01-06 | 2007-08-17 | Astrazeneca Ab | Compuestos de piridina novedosos. |
US20090286834A1 (en) * | 2006-07-04 | 2009-11-19 | Astrazeneca Ab | Pyridine Analogues VI |
MX2008016557A (es) * | 2006-07-04 | 2009-02-06 | Astrazeneca Ab | Analogos de piridina nuevos. |
US20080009523A1 (en) * | 2006-07-04 | 2008-01-10 | Astrazeneca Ab | New Pyridine Analogues IV |
-
2006
- 2006-07-04 US US11/995,326 patent/US20080312208A1/en not_active Abandoned
- 2006-07-04 EP EP06758023A patent/EP1904474A4/en not_active Withdrawn
- 2006-07-04 MX MX2008000470A patent/MX2008000470A/es not_active Application Discontinuation
- 2006-07-04 KR KR1020087002914A patent/KR20080039405A/ko not_active Application Discontinuation
- 2006-07-04 RU RU2008101924/04A patent/RU2008101924A/ru not_active Application Discontinuation
- 2006-07-04 WO PCT/SE2006/000832 patent/WO2007008140A1/en active Application Filing
- 2006-07-04 JP JP2008521353A patent/JP2009501216A/ja active Pending
- 2006-07-04 CA CA002614726A patent/CA2614726A1/en not_active Abandoned
- 2006-07-04 AU AU2006267148A patent/AU2006267148A1/en not_active Abandoned
- 2006-07-12 UY UY29667A patent/UY29667A1/es not_active Application Discontinuation
- 2006-07-12 AR ARP060102992A patent/AR054632A1/es not_active Application Discontinuation
- 2006-07-13 TW TW095125590A patent/TW200726758A/zh unknown
-
2007
- 2007-12-20 IL IL188293A patent/IL188293A0/en unknown
- 2007-12-28 NO NO20076682A patent/NO20076682L/no not_active Application Discontinuation
-
2008
- 2008-01-25 EC EC2008008140A patent/ECSP088140A/es unknown
Also Published As
Publication number | Publication date |
---|---|
NO20076682L (no) | 2008-03-05 |
EP1904474A4 (en) | 2010-06-16 |
CA2614726A1 (en) | 2007-01-18 |
US20080312208A1 (en) | 2008-12-18 |
MX2008000470A (es) | 2008-03-11 |
EP1904474A1 (en) | 2008-04-02 |
WO2007008140A1 (en) | 2007-01-18 |
IL188293A0 (en) | 2008-04-13 |
ECSP088140A (es) | 2008-02-20 |
AU2006267148A1 (en) | 2007-01-18 |
JP2009501216A (ja) | 2009-01-15 |
RU2008101924A (ru) | 2009-08-20 |
TW200726758A (en) | 2007-07-16 |
KR20080039405A (ko) | 2008-05-07 |
UY29667A1 (es) | 2007-02-28 |
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