MA35184B1 - Antagonistes de trpv4 - Google Patents
Antagonistes de trpv4Info
- Publication number
- MA35184B1 MA35184B1 MA36564A MA36564A MA35184B1 MA 35184 B1 MA35184 B1 MA 35184B1 MA 36564 A MA36564 A MA 36564A MA 36564 A MA36564 A MA 36564A MA 35184 B1 MA35184 B1 MA 35184B1
- Authority
- MA
- Morocco
- Prior art keywords
- trpv4
- compounds
- antagonists
- relates
- spirocarbamate
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne des composés de spirocarbamate de formule (i) dans laquelle r1, (r2)y, r3, r4, x et a étant tels que définis dans la description. Par ailleurs, l'invention concerne des compositions pharmaceutiques contenant ces composés ou des sels pharmaceutiquement acceptables de ceux-ci, ainsi que l'utilisation de ces composés comme antagonistes de trpv4 dans le traitement ou la prévention d'états pathologiques associés au déséquilibre de trpv4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161498110P | 2011-06-17 | 2011-06-17 | |
PCT/US2012/042622 WO2013012500A1 (fr) | 2011-06-17 | 2012-06-15 | Antagonistes de trpv4 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35184B1 true MA35184B1 (fr) | 2014-06-02 |
Family
ID=47558389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36564A MA35184B1 (fr) | 2011-06-17 | 2013-12-13 | Antagonistes de trpv4 |
Country Status (38)
Country | Link |
---|---|
US (1) | US9187464B2 (fr) |
EP (2) | EP2721016B1 (fr) |
JP (1) | JP5969017B2 (fr) |
KR (1) | KR101870003B1 (fr) |
CN (1) | CN103732583B (fr) |
AR (1) | AR086958A1 (fr) |
AU (1) | AU2012284540B2 (fr) |
BR (1) | BR112013032391B1 (fr) |
CA (1) | CA2839743C (fr) |
CL (1) | CL2013003602A1 (fr) |
CO (1) | CO6821953A2 (fr) |
CR (1) | CR20130671A (fr) |
CY (1) | CY1117792T1 (fr) |
DK (1) | DK2721016T3 (fr) |
DO (1) | DOP2013000307A (fr) |
EA (1) | EA023616B1 (fr) |
ES (2) | ES2688733T3 (fr) |
HK (1) | HK1195068A1 (fr) |
HR (1) | HRP20160539T1 (fr) |
HU (1) | HUE029594T2 (fr) |
IL (1) | IL229872A (fr) |
JO (1) | JO3154B1 (fr) |
MA (1) | MA35184B1 (fr) |
ME (1) | ME02416B (fr) |
MX (1) | MX337440B (fr) |
MY (1) | MY173521A (fr) |
PE (1) | PE20141943A1 (fr) |
PL (1) | PL2721016T3 (fr) |
PT (1) | PT2721016E (fr) |
RS (1) | RS54858B1 (fr) |
SG (1) | SG195106A1 (fr) |
SI (1) | SI2721016T1 (fr) |
SM (1) | SMT201600150B (fr) |
TW (1) | TWI538912B (fr) |
UA (1) | UA113963C2 (fr) |
UY (1) | UY34138A (fr) |
WO (1) | WO2013012500A1 (fr) |
ZA (1) | ZA201308816B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2571409T3 (es) | 2011-06-17 | 2016-05-25 | Glaxosmithkline Intellectual Property (No 2) Ltd | Antagonistas espiro-cíclicos de TRPV4 |
EP2720697B1 (fr) * | 2011-06-17 | 2016-07-20 | Glaxosmithkline Intellectual Property (No. 2) Limited | Antagonistes de trpv4 |
US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
JPWO2015046193A1 (ja) | 2013-09-25 | 2017-03-09 | 塩野義製薬株式会社 | Trpv4阻害活性を有する芳香族複素環式アミン誘導体 |
JP6970691B2 (ja) * | 2016-05-19 | 2021-11-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | Trpv4拮抗薬 |
US10968209B2 (en) | 2016-05-19 | 2021-04-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonist |
TN2019000087A1 (en) | 2016-10-03 | 2020-07-15 | Janssen Pharmaceutica Nv | Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors |
WO2018185701A1 (fr) | 2017-04-06 | 2018-10-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Antagonistes de trpv4 en tant qu'agents antitussifs |
SG11202003825TA (en) * | 2017-11-01 | 2020-05-28 | Bristol Myers Squibb Co | Spirocyclic compounds as farnesoid x receptor modulators |
WO2021170811A1 (fr) | 2020-02-27 | 2021-09-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Méthode de traitement d'une maladie oculaire à l'aide d'antagonistes de trpv4 |
EP4142874A4 (fr) | 2020-04-30 | 2024-05-22 | RaQualia Pharma Inc. | Dérivés de pyrimidin-4 (3h)-one utilisés en tant qu'antagonistes de trpv4 |
CN111704613B (zh) * | 2020-06-23 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 咪唑类衍生物及其作为trpv4抑制剂的用途 |
CN115776890A (zh) | 2020-07-16 | 2023-03-10 | 拉夸里亚创药株式会社 | 作为眼病治疗剂的trpv4抑制剂 |
TW202409024A (zh) | 2022-07-08 | 2024-03-01 | 美商愛克堤歐生物科學公司 | 治療性化合物及方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3851199A (en) * | 1998-05-26 | 1999-12-13 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic indole derivatives and mono- or diazaindole derivatives |
CA2531619A1 (fr) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Analogues de biaryl piperazinyl-pyridine |
CA2630617C (fr) * | 2005-11-23 | 2014-03-25 | Painceptor Pharma Corporation | Compositions et procedes de modulation des canaux ioniques |
WO2007067756A2 (fr) | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certains types d'entites chimiques, compositions et methode de modulation de trpv1 |
TWI649092B (zh) * | 2005-12-22 | 2019-02-01 | 海卓勒生物科學公司 | 用於調節trpa1功能之化合物 |
TW200819457A (en) * | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
JP2010517967A (ja) * | 2007-02-01 | 2010-05-27 | グラクソ グループ リミテッド | 摂食障害の治療のための1−オキサ−3−アザスピロ[4,5]デカン−2−オン誘導体 |
GB0707934D0 (en) * | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
US7998982B2 (en) * | 2007-08-09 | 2011-08-16 | Abbott Laboratories | Amide derivatives as TRPV1 antagonists |
TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
JP5607046B2 (ja) * | 2008-07-25 | 2014-10-15 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Trpv4拮抗薬 |
JP2012006837A (ja) * | 2008-09-30 | 2012-01-12 | Mochida Pharmaceut Co Ltd | 2−インドールアクリルアミド類縁体 |
EP2605658B1 (fr) * | 2010-08-18 | 2016-03-23 | Merck Sharp & Dohme Corp. | Composés spiroxazolidinone |
EP2720697B1 (fr) * | 2011-06-17 | 2016-07-20 | Glaxosmithkline Intellectual Property (No. 2) Limited | Antagonistes de trpv4 |
ES2571409T3 (es) * | 2011-06-17 | 2016-05-25 | Glaxosmithkline Intellectual Property (No 2) Ltd | Antagonistas espiro-cíclicos de TRPV4 |
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2012
- 2012-06-14 JO JOP/2012/0159A patent/JO3154B1/ar active
- 2012-06-15 JP JP2014516020A patent/JP5969017B2/ja active Active
- 2012-06-15 WO PCT/US2012/042622 patent/WO2013012500A1/fr active Application Filing
- 2012-06-15 ES ES16162808T patent/ES2688733T3/es active Active
- 2012-06-15 EP EP12814591.9A patent/EP2721016B1/fr active Active
- 2012-06-15 AR ARP120102143A patent/AR086958A1/es active IP Right Grant
- 2012-06-15 MX MX2013014898A patent/MX337440B/es active IP Right Grant
- 2012-06-15 EA EA201490037A patent/EA023616B1/ru not_active IP Right Cessation
- 2012-06-15 EP EP16162808.6A patent/EP3121177B1/fr active Active
- 2012-06-15 SG SG2013086483A patent/SG195106A1/en unknown
- 2012-06-15 PE PE2013002807A patent/PE20141943A1/es active IP Right Grant
- 2012-06-15 PL PL12814591T patent/PL2721016T3/pl unknown
- 2012-06-15 SI SI201230564A patent/SI2721016T1/sl unknown
- 2012-06-15 PT PT128145919T patent/PT2721016E/pt unknown
- 2012-06-15 ES ES12814591T patent/ES2569193T3/es active Active
- 2012-06-15 KR KR1020147000958A patent/KR101870003B1/ko not_active Application Discontinuation
- 2012-06-15 CN CN201280039690.0A patent/CN103732583B/zh active Active
- 2012-06-15 UA UAA201400152A patent/UA113963C2/uk unknown
- 2012-06-15 MY MYPI2013702447A patent/MY173521A/en unknown
- 2012-06-15 US US14/125,378 patent/US9187464B2/en active Active
- 2012-06-15 BR BR112013032391-4A patent/BR112013032391B1/pt active IP Right Grant
- 2012-06-15 TW TW101121449A patent/TWI538912B/zh active
- 2012-06-15 RS RS20160417A patent/RS54858B1/sr unknown
- 2012-06-15 HU HUE12814591A patent/HUE029594T2/en unknown
- 2012-06-15 UY UY0001034138A patent/UY34138A/es not_active Application Discontinuation
- 2012-06-15 ME MEP-2016-120A patent/ME02416B/fr unknown
- 2012-06-15 DK DK12814591.9T patent/DK2721016T3/en active
- 2012-06-15 AU AU2012284540A patent/AU2012284540B2/en active Active
- 2012-06-15 CA CA2839743A patent/CA2839743C/fr active Active
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2013
- 2013-11-22 ZA ZA2013/08816A patent/ZA201308816B/en unknown
- 2013-12-09 IL IL229872A patent/IL229872A/en active IP Right Grant
- 2013-12-11 CO CO13290152A patent/CO6821953A2/es active IP Right Grant
- 2013-12-13 MA MA36564A patent/MA35184B1/fr unknown
- 2013-12-16 CL CL2013003602A patent/CL2013003602A1/es unknown
- 2013-12-17 DO DO2013000307A patent/DOP2013000307A/es unknown
- 2013-12-17 CR CR20130671A patent/CR20130671A/es unknown
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2014
- 2014-08-20 HK HK14108527.9A patent/HK1195068A1/zh unknown
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2016
- 2016-05-19 HR HRP20160539TT patent/HRP20160539T1/hr unknown
- 2016-05-31 SM SM201600150T patent/SMT201600150B/it unknown
- 2016-06-21 CY CY20161100556T patent/CY1117792T1/el unknown
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MA34896B1 (fr) | Inhibiteurs du virus de l'hepatite c | |
MA35576B1 (fr) | Nouveaux composés | |
MA37929A1 (fr) | Composés bis(fluoroalkyl) -1,4-benzodiazépinones en tant qu'inhibiteurs de notch | |
MA30821B1 (fr) | Derives de pyrazoline utiles comme antagonistes des recepteurs de mineralocorticoïdes | |
MA35364B1 (fr) | Dérivés hétérocycliques bicycliques pour le traitement d'une hypertension artérielle pulmonaire | |
MA33384B1 (fr) | Sulfonamides hétérocycliques, leurs utilisations et compositions pharmaceutiques les contenant | |
MA33420B1 (fr) | Dérivés fluorés de l'aminotriazole |