EA201790088A1 - Ингибиторы syk - Google Patents

Ингибиторы syk

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Publication number
EA201790088A1
EA201790088A1 EA201790088A EA201790088A EA201790088A1 EA 201790088 A1 EA201790088 A1 EA 201790088A1 EA 201790088 A EA201790088 A EA 201790088A EA 201790088 A EA201790088 A EA 201790088A EA 201790088 A1 EA201790088 A1 EA 201790088A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
formula
pharmaceutically acceptable
syk
subject
Prior art date
Application number
EA201790088A
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English (en)
Inventor
Питер А. Бломгрен
Астрид Кларк
Кевин С. Карри
Джули Ди Паоло
Джеффри И. Кропф
Сын Х. Ли
Дженнифер Р. Ло
Скотт А. Митчелл
Аарон К. Шмитт
Сандарамурти Сваминатан
Цзинь-Мин Сюн
Цзяньцзюнь Сюй
Чжундун Чжао
Original Assignee
Джилид Сайэнс, Инк.
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Publication date
Application filed by Джилид Сайэнс, Инк. filed Critical Джилид Сайэнс, Инк.
Publication of EA201790088A1 publication Critical patent/EA201790088A1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Настоящее изобретение относится к соединениям, которые являются ингибиторами Syk, и к их применению для лечения различных болезненных состояний, включая рак и воспалительные состояния. В конкретных вариантах реализации структура соединений представлена формулой Iгде R, R, Rи Rявляются такими, как указано в описании изобретения. В настоящем изобретении также предложены фармацевтические композиции, которые содержат соединение формулы I или его фармацевтически приемлемые соли, и способы применения указанных соединений и композиций для лечения состояний, опосредованных Syk. В некоторых вариантах реализации также предложены способы лечения рака у нуждающегося в этом субъекта (например, человека), включающие введение указанному субъекту терапевтически эффективного количества соединения формулы I или его фармацевтически приемлемой соли в комбинации с алкалоидом барвинка или его фармацевтически приемлемой солью.
EA201790088A 2014-07-14 2015-07-09 Ингибиторы syk EA201790088A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462024284P 2014-07-14 2014-07-14
PCT/US2015/039677 WO2016010809A1 (en) 2014-07-14 2015-07-09 Syk inhibitors

Publications (1)

Publication Number Publication Date
EA201790088A1 true EA201790088A1 (ru) 2017-07-31

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EA201790088A EA201790088A1 (ru) 2014-07-14 2015-07-09 Ингибиторы syk

Country Status (16)

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US (3) US9504684B2 (ru)
EP (1) EP3169329A1 (ru)
JP (2) JP6292691B2 (ru)
KR (1) KR20170023186A (ru)
CN (1) CN106572999A (ru)
AR (1) AR101177A1 (ru)
AU (2) AU2015290041B2 (ru)
CA (1) CA2955249A1 (ru)
EA (1) EA201790088A1 (ru)
MA (1) MA40076A (ru)
MX (1) MX2017000612A (ru)
NZ (1) NZ726366A (ru)
SG (1) SG11201610904UA (ru)
TW (1) TW201617074A (ru)
UY (1) UY36207A (ru)
WO (1) WO2016010809A1 (ru)

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EA031601B1 (ru) 2013-07-31 2019-01-31 Джилид Сайэнс, Инк. Ингибиторы syk
EP3076976B1 (en) 2013-12-04 2020-09-02 Gilead Sciences, Inc. Methods for treating cancers
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
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EA201790086A1 (ru) 2014-07-14 2017-07-31 Джилид Сайэнс, Инк. Комбинации для лечения раковых заболеваний
DK3347353T3 (da) * 2015-09-11 2019-10-21 Boehringer Ingelheim Int Pyrazolyl-substituerede heteroaryler og deres anvendelse som lægemidler
US10261071B2 (en) * 2016-07-13 2019-04-16 The United States Of America As Represented By The Secretary Of The Navy Volatile organic compounds as diagnostic breath markers for pulmonary oxygen toxicity
TW201822764A (zh) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk抑制劑
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