MX2009008953A - Compuestos como inhibidores de angiogenesis. - Google Patents

Compuestos como inhibidores de angiogenesis.

Info

Publication number
MX2009008953A
MX2009008953A MX2009008953A MX2009008953A MX2009008953A MX 2009008953 A MX2009008953 A MX 2009008953A MX 2009008953 A MX2009008953 A MX 2009008953A MX 2009008953 A MX2009008953 A MX 2009008953A MX 2009008953 A MX2009008953 A MX 2009008953A
Authority
MX
Mexico
Prior art keywords
angiogenesis inhibitors
substituted compounds
spiro
tyrosine kinases
spiro substituted
Prior art date
Application number
MX2009008953A
Other languages
English (en)
Inventor
Guoqing Paul Chen
Original Assignee
Advenchen Lab Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advenchen Lab Llc filed Critical Advenchen Lab Llc
Publication of MX2009008953A publication Critical patent/MX2009008953A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(Ver fórmula I) La presente invención se refiere al compuesto de La Formula I, procesos para su preparación, composiciones farmacéuticas que lo contenga como un ingrediente, activo, métodos para el tratamiento de enfermedades asociadas con la angiogénesis, tales como los cánceres asociados con la proteína tirosina cinasa, para su uso como medicamentos para utilizado en la producción de la inhibición de la tirosina cinasa reduciendo los efectos en animales de sangre caliente como los humanos.
MX2009008953A 2007-03-14 2008-02-24 Compuestos como inhibidores de angiogenesis. MX2009008953A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89469207P 2007-03-14 2007-03-14
US94169807P 2007-06-04 2007-06-04
US12/036,244 US8148532B2 (en) 2007-03-14 2008-02-23 Spiro substituted compounds as angiogenesis inhibitors
PCT/US2008/054816 WO2008112407A1 (en) 2007-03-14 2008-02-24 Spiro substituted compounds as angiogenesis inhibitors

Publications (1)

Publication Number Publication Date
MX2009008953A true MX2009008953A (es) 2009-12-18

Family

ID=39759893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008953A MX2009008953A (es) 2007-03-14 2008-02-24 Compuestos como inhibidores de angiogenesis.

Country Status (16)

Country Link
US (1) US8148532B2 (es)
EP (1) EP2125776B1 (es)
JP (1) JP5522371B2 (es)
KR (1) KR101514469B1 (es)
CN (4) CN105837559B (es)
AU (1) AU2008226666B2 (es)
BR (1) BRPI0805826B8 (es)
CA (1) CA2709220C (es)
DK (1) DK2125776T3 (es)
ES (1) ES2643619T3 (es)
IL (1) IL200934A0 (es)
MX (1) MX2009008953A (es)
NZ (1) NZ579389A (es)
PL (1) PL2125776T3 (es)
PT (1) PT2125776T (es)
WO (1) WO2008112407A1 (es)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163923B2 (en) * 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
US8211911B2 (en) 2008-08-19 2012-07-03 Guoqing Paul Chen Compounds as kinase inhibitors
MX2011004018A (es) * 2008-10-14 2011-06-24 Ning Xi Compuestos y metodos de uso.
KR20110133048A (ko) * 2009-03-21 2011-12-09 닝 시 아미노 에스테르 유도체, 그의 염 및 이용 방법
CN103664890B (zh) * 2010-08-01 2016-10-05 正大天晴药业集团股份有限公司 喹啉衍生物的结晶及制备方法
CN103664892B (zh) * 2010-08-01 2015-09-02 正大天晴药业集团股份有限公司 喹啉衍生物的结晶
US8664244B2 (en) * 2010-09-12 2014-03-04 Advenchen Pharmaceuticals, LLC Compounds as c-Met kinase inhibitors
EA023998B1 (ru) 2011-03-04 2016-08-31 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Аминохинолины в качестве ингибиторов киназ
TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
WO2014032019A2 (en) * 2012-08-23 2014-02-27 Georgetown University Compounds and methods of use thereof for treating tumors
TW201425307A (zh) 2012-09-13 2014-07-01 Glaxosmithkline Llc 作為激酶抑制劑之胺基－喹啉類
AR092529A1 (es) 2012-09-13 2015-04-22 Glaxosmithkline Llc Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
CN104936946A (zh) * 2013-01-18 2015-09-23 爱德程制药有限公司 制备抗肿瘤剂6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其结晶
EP2956138B1 (en) 2013-02-15 2022-06-22 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
WO2014127335A1 (en) * 2013-02-15 2014-08-21 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
ES2831625T3 (es) * 2013-02-20 2021-06-09 Kala Pharmaceuticals Inc Compuestos terapéuticos y sus usos
JP6301374B2 (ja) 2013-02-21 2018-03-28 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ キナーゼ阻害剤としてのキナゾリン類
CN105311029A (zh) * 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CN105213394B (zh) * 2014-06-06 2019-04-09 正大天晴药业集团股份有限公司 具有抗肿瘤活性的喹啉衍生物
CN105311030B (zh) * 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
AU2015290007B2 (en) 2014-07-14 2019-11-21 Advenchen Pharmaceuticals, Nanjing Ltd. Fused quinoline compunds as pi3k, mTor inhibitors
WO2016091167A1 (zh) * 2014-12-09 2016-06-16 正大天晴药业集团股份有限公司 抗肺鳞癌的喹啉衍生物
EP3231797B1 (en) * 2014-12-09 2020-02-26 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative against non-small cell lung cancer
CN112057451A (zh) * 2014-12-09 2020-12-11 正大天晴药业集团股份有限公司 治疗非小细胞肺癌的喹啉衍生物
US9751859B2 (en) * 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
ES2782113T3 (es) 2015-07-11 2020-09-10 Advenchen Pharmaceuticals Llc Compuestos de quinolina fusionados como inhibidores de PI3K/mTor
WO2017035114A1 (en) 2015-08-25 2017-03-02 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as cb-1 inverse agonists
KR20180086187A (ko) 2015-10-05 2018-07-30 더 트러스티이스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 자가포식 유동의 활성체 및 포스포리파제 d 및 타우를 포함하는 단백질 응집물의 클리어런스 및 단백질질환의 치료
CN108601778A (zh) * 2016-01-08 2018-09-28 正大天晴药业集团股份有限公司 喹啉衍生物用于治疗食管癌的用途及其治疗方法、药物组合物和试剂盒
CN107296811B (zh) * 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
CN107778288B (zh) * 2016-08-26 2020-07-28 正大天晴药业集团股份有限公司 一种喹啉衍生物的杂质及其制备方法和用途
CN107778290B (zh) * 2016-08-30 2020-07-24 正大天晴药业集团股份有限公司 一种喹啉衍生物的杂质及其制备方法
WO2018214925A1 (zh) * 2017-05-26 2018-11-29 正大天晴药业集团股份有限公司 用于治疗结直肠癌的喹啉衍生物
CN109422731A (zh) * 2017-08-24 2019-03-05 正大天晴药业集团股份有限公司 氘代喹啉衍生物
WO2019052520A1 (zh) 2017-09-15 2019-03-21 正大天晴药业集团股份有限公司 用于治疗神经内分泌肿瘤的喹啉衍生物
CN107970241B (zh) * 2018-01-22 2020-05-22 正大天晴药业集团股份有限公司 一种新型酪氨酸激酶抑制剂安罗替尼在制备抑制骨肉瘤的药物中的应用
CN111630045A (zh) * 2018-02-11 2020-09-04 正大天晴药业集团股份有限公司 喹啉衍生物的结晶
CN115057815A (zh) 2018-03-02 2022-09-16 正大天晴药业集团股份有限公司 作为c-Met激酶抑制剂的化合物的结晶及其制备方法和用途
JP7270633B2 (ja) * 2018-03-14 2023-05-10 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 上咽頭がん治療用キノリン誘導体
US11419862B2 (en) 2018-03-14 2022-08-23 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative for treatment of nasopharyngeal carcinoma
WO2019174590A1 (zh) * 2018-03-14 2019-09-19 正大天晴药业集团股份有限公司 用于治疗三阴性乳腺癌的喹啉衍生物
CN110357856B (zh) * 2018-04-09 2021-02-26 新发药业有限公司 一种盐酸安罗替尼中间体及盐酸安罗替尼的制备方法
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体
WO2019223672A1 (zh) * 2018-05-22 2019-11-28 正大天晴药业集团股份有限公司 用于治疗非小细胞肺癌的喹啉衍生物
WO2019233458A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 Vegfr抑制剂及其制备方法和应用
CN110577546B (zh) * 2018-06-08 2021-09-07 江苏威凯尔医药科技有限公司 Vegfr抑制剂及其制备方法和应用
EP3816161A4 (en) * 2018-06-25 2022-03-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. CRYSTAL HABITUS OF A QUINOLINE DERIVATIVE AND PROCESS FOR PRODUCTION OF CRYSTALLINE POWDER
KR20210034613A (ko) 2018-07-18 2021-03-30 치아타이 티안큉 파마수티컬 그룹 주식회사 퀴놀린 유도체 및 항체의 약물 조합
CN112469711A (zh) * 2018-07-24 2021-03-09 正大天晴药业集团股份有限公司 一种喹啉衍生物的合成方法
CN108864050B (zh) * 2018-07-25 2019-12-10 上海博璞诺科技发展有限公司 一种合成安罗替尼及其盐酸盐的方法
WO2020029918A1 (zh) * 2018-08-06 2020-02-13 正大天晴药业集团股份有限公司 用于治疗结外nk/t细胞淋巴瘤的喹啉衍生物
EP3854396A4 (en) 2018-09-18 2022-06-29 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative used for treating small cell lung cancer
WO2020057403A1 (zh) * 2018-09-18 2020-03-26 北京越之康泰生物医药科技有限公司 吲哚衍生物及其在医药上的应用
CN109705093A (zh) * 2018-12-29 2019-05-03 正大天晴药业集团股份有限公司 喹啉衍生物及其制备方法和用途
CN109748904A (zh) 2019-01-31 2019-05-14 正大天晴药业集团股份有限公司 喹啉衍生物的结晶
CN111617243B (zh) * 2019-02-28 2023-12-19 正大天晴药业集团股份有限公司 喹啉衍生物与抗体的药物组合
CN111643503A (zh) * 2019-03-04 2020-09-11 正大天晴药业集团股份有限公司 用于治疗非小细胞肺癌的喹啉衍生物
CN117797151A (zh) * 2019-03-04 2024-04-02 正大天晴药业集团股份有限公司 喹啉衍生物联合化疗药物用于治疗非小细胞肺癌
CN111714498A (zh) * 2019-03-20 2020-09-29 正大天晴药业集团股份有限公司 用于治疗卵巢癌的喹啉衍生物
CA3137204A1 (en) 2019-04-19 2020-10-22 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline compound or pharmaceutically acceptable salt thereof for treating ewing's sarcoma
CN111840289A (zh) * 2019-04-28 2020-10-30 正大天晴药业集团股份有限公司 用于治疗骨巨细胞瘤的喹啉类化合物或其药学上可接受的盐
US20220313685A1 (en) 2019-05-10 2022-10-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative and antibody soft tissue sarcoma combination therapy
AU2020273687A1 (en) 2019-05-10 2022-01-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative used for soft tissue sarcoma combination therapy
EP4008351A4 (en) 2019-08-02 2023-08-09 CTTQ-Akeso (ShangHai) Biomed. Tech. Co., Ltd. ANTI-PD-1 ANTIBODIES AND ASSOCIATED MEDICAL USE
EP4008730A4 (en) 2019-08-02 2023-09-06 Akeso Pharmaceuticals, Inc. BISPECIFIC ANTI-CTLA4-ANTI-PD-1 ANTIBODY AND ITS USES
WO2021088853A1 (zh) 2019-11-04 2021-05-14 正大天晴药业集团股份有限公司 喹啉衍生物与pd-1单抗的药物组合
WO2021143928A1 (zh) * 2020-01-19 2021-07-22 正大天晴药业集团股份有限公司 用于治疗类风湿性关节炎的喹啉衍生物
CN113262223A (zh) * 2020-02-17 2021-08-17 上海交通大学医学院 安罗替尼及其药学上可接受的盐在制备治疗多发性骨髓瘤药物中的应用
CN112358469A (zh) * 2020-03-18 2021-02-12 北京康辰药业股份有限公司 血管生成抑制剂、其制备方法及其应用
CN112912373B (zh) * 2020-03-18 2022-08-23 北京康辰药业股份有限公司 血管生成抑制剂、其制备方法和应用
CN111888358A (zh) * 2020-08-24 2020-11-06 天津济坤医药科技有限公司 安罗替尼在制备用于治疗肝纤维化疾病的药物中的应用
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2024180476A1 (en) 2023-02-27 2024-09-06 Assia Chemical Industries Ltd. Solid state forms of anlotinib and process for preparation thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227989A1 (de) 1992-08-21 1994-06-09 Schering Ag Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel
DE69622183D1 (de) 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
KR100838617B1 (ko) 1999-02-10 2008-06-16 아스트라제네카 아베 혈관형성 억제제로서의 퀴나졸린 유도체
KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
EP1548008A4 (en) * 2002-08-23 2008-08-06 Kirin Pharma Kk COMPOUND HAVING BETA-TRANSFORMING GROWTH FACTOR INHIBITORY ACTIVITY AND DRUG CONTAINING COMPOSITION
US7129252B2 (en) * 2003-06-16 2006-10-31 Guoqing P Chen Six membered amino-amide derivatives an angiogenisis inhibitors
CA2536788A1 (en) 2003-08-29 2005-03-10 Pfizer Inc. Naphthalene carboxamides and their derivatives useful as new anti-angiogenic agents
MXPA06005024A (es) * 2003-11-06 2006-07-06 Pfizer Prod Inc Combinaciones de inhibidor de erbb2 selectivo/anticuerpos anti-erbb en el tratamiento del cancer.
MXPA06007242A (es) * 2003-12-23 2006-08-18 Pfizer Nuevos derivados de quinolina.
TW200536851A (en) 2004-01-23 2005-11-16 Amgen Inc Compounds and methods of use
JP2007518823A (ja) * 2004-01-23 2007-07-12 アムゲン インコーポレイテッド キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途
WO2005080377A1 (ja) 2004-02-20 2005-09-01 Kirin Beer Kabushiki Kaisha TGFβ阻害活性を有する化合物およびそれを含んでなる医薬組成物
WO2005097137A2 (en) 2004-03-31 2005-10-20 The Scripps Research Institute Advanced quinazoline based protein kinase inhibitors
US20080268460A1 (en) 2004-05-20 2008-10-30 Wyeth Assays to Identify Irreversibly Binding Inhibitors of Receptor Tyrosine Kinases
KR100735639B1 (ko) * 2004-12-29 2007-07-04 한미약품 주식회사 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
AU2006231646A1 (en) 2005-04-06 2006-10-12 Exelixis, Inc. C-Met modulators and methods of use
US8163923B2 (en) * 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors

Also Published As

Publication number Publication date
CN105837559A (zh) 2016-08-10
JP2010521473A (ja) 2010-06-24
CN101809012A (zh) 2010-08-18
EP2125776A4 (en) 2011-06-22
ES2643619T3 (es) 2017-11-23
US20080227811A1 (en) 2008-09-18
PL2125776T3 (pl) 2017-12-29
WO2008112407A1 (en) 2008-09-18
KR101514469B1 (ko) 2015-04-22
IL200934A0 (en) 2010-05-17
BRPI0805826A2 (pt) 2011-08-30
AU2008226666A1 (en) 2008-09-18
CN105837559B (zh) 2019-11-29
JP5522371B2 (ja) 2014-06-18
NZ579389A (en) 2012-04-27
CN103483319B (zh) 2015-10-14
BRPI0805826B8 (pt) 2021-05-25
CN103467454A (zh) 2013-12-25
CN101809012B (zh) 2013-11-27
CA2709220C (en) 2016-07-19
KR20090129985A (ko) 2009-12-17
CN103467454B (zh) 2016-05-04
US8148532B2 (en) 2012-04-03
EP2125776A1 (en) 2009-12-02
CA2709220A1 (en) 2008-09-18
AU2008226666B2 (en) 2013-10-03
BRPI0805826B1 (pt) 2021-02-09
PT2125776T (pt) 2017-10-04
CN103483319A (zh) 2014-01-01
EP2125776B1 (en) 2017-07-05
DK2125776T3 (en) 2017-10-23

Similar Documents

Publication Publication Date Title
MX2009008953A (es) Compuestos como inhibidores de angiogenesis.
MX2009009843A (es) Compuestos espiro sustituidos como inhibidores de la angiogenesis.
AU2009282962A8 (en) Compounds as kinase inhibitors
WO2012034055A3 (en) Compounds as c-met kinase inhibitors
MX2009004699A (es) Compuestos de piridinona.
EA201000552A1 (ru) Производные пирроло[2,3-d]пиримидина в качестве ингибиторов протеинкиназы в
GEP20156285B (en) Compounds and compositions as trk inhibitors
WO2008145688A3 (en) Pyrrolopyridine compounds, process for their preparation, and their use as medicaments
MX2010014057A (es) Compuestos de piridina.
MX2009002171A (es) Derivados de triazol como inhibidores de cinasas.
MX336051B (es) Diarilacetileno hidracido que contiene inhibidores de tirosina quinasa.
GEP20146146B (en) Pyrrolopyrimidine compounds as inhibitors of cdk4/6
EA201000090A1 (ru) Тризамещенные производные пиримидина для лечения пролиферативных заболеваний
EP1973407A4 (en) SPIRO COMPOUNDS AND METHODS OF USE
GEP20166484B (en) Protein kinase inhibitors
MX2011012337A (es) Nuevos derivados de pirimidina y su uso en el tratamiento de cancer y de otras enfermedades.
MX2009012066A (es) Imidazopirinas sustituidas como inhibidoras de cinasa de lipido p13k.
WO2009132774A8 (en) New substituted indolin-2-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EA201100503A1 (ru) Глюкозидные производные и их применения
EA201000092A1 (ru) Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний
MX2009004745A (es) Derivados de 1,2,3-triazol como inhibidores del receptor sigma.
IN2012DN01453A (es)
MX2010013682A (es) Derivados de 2,4-diamino-l,3,5-triazina triciclicos utiles para el tratamiento del cancer y trastornos mieloproliferativos.
MX2012001838A (es) Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion.
MX2009009153A (es) Pirano-pirazol-aminas.

Legal Events

Date Code Title Description
FG Grant or registration