EA201070543A1 - Новые 4-(тетразол-5-ил) хиназолиновые производные в качестве противораковых средств - Google Patents

Новые 4-(тетразол-5-ил) хиназолиновые производные в качестве противораковых средств

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Publication number
EA201070543A1
EA201070543A1 EA201070543A EA201070543A EA201070543A1 EA 201070543 A1 EA201070543 A1 EA 201070543A1 EA 201070543 A EA201070543 A EA 201070543A EA 201070543 A EA201070543 A EA 201070543A EA 201070543 A1 EA201070543 A1 EA 201070543A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrazol
derivatives
hinazoline
new
treatment means
Prior art date
Application number
EA201070543A
Other languages
English (en)
Other versions
EA018716B1 (ru
Inventor
Дурга Прасад Конаканчи
Субба Рао Пула
Лакшми Анантханени
Муддасани Пулла Редди
Бхуджанга Рао Адибхатла Кали Сатиа
Наннапанени Венкайах Човдари
Original Assignee
Натко Фарма Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Натко Фарма Лимитед filed Critical Натко Фарма Лимитед
Publication of EA201070543A1 publication Critical patent/EA201070543A1/ru
Publication of EA018716B1 publication Critical patent/EA018716B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к замещенным 4-(тетразол-5-ил)хиназолиновым производным формулы I или их фармацевтически приемлемым солям, которые обладают антипролиферативной активностью, такой как противораковая активность, и, соответственно, являются пригодными в способах лечения человека и животного. Настоящее изобретение также относится к способам получения замещенных 4-(тетразол-5-ил)хиназолиновых производных, к фармацевтическим композициям, содержащим данные соединения, и к их применению для получения лекарственных средств для оказания антипролиферативного действия на теплокровного животного, такого как человек.
EA201070543A 2007-10-29 2008-10-28 Новые 4-(тетразол-5-ил) хиназолиновые производные в качестве противораковых средств EA018716B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2445CH2007 2007-10-29
PCT/IN2008/000708 WO2009057139A2 (en) 2007-10-29 2008-10-28 Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents

Publications (2)

Publication Number Publication Date
EA201070543A1 true EA201070543A1 (ru) 2010-12-30
EA018716B1 EA018716B1 (ru) 2013-10-30

Family

ID=40433677

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070543A EA018716B1 (ru) 2007-10-29 2008-10-28 Новые 4-(тетразол-5-ил) хиназолиновые производные в качестве противораковых средств

Country Status (15)

Country Link
US (1) US8080558B2 (ru)
EP (1) EP2220054A2 (ru)
JP (1) JP2011502141A (ru)
KR (1) KR20100087185A (ru)
CN (1) CN101878203A (ru)
AU (1) AU2008320342B2 (ru)
CA (1) CA2703767A1 (ru)
EA (1) EA018716B1 (ru)
GE (1) GEP20125603B (ru)
MX (1) MX2010004625A (ru)
MY (1) MY150054A (ru)
NZ (1) NZ585357A (ru)
UA (1) UA101168C2 (ru)
WO (1) WO2009057139A2 (ru)
ZA (1) ZA201002807B (ru)

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CN103130729B (zh) * 2011-12-05 2015-07-15 齐鲁制药有限公司 一种4-氯代-7-甲氧基喹唑啉-6-醇乙酸酯的制备方法
EP2892534B8 (en) * 2012-09-06 2021-09-15 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN102993114B (zh) * 2012-10-11 2015-08-12 南通市华峰化工有限责任公司 一种1h-四唑-5-乙酸的生产方法
CN103204817B (zh) * 2013-04-16 2018-03-27 江西师范大学 4‑氰基喹唑啉衍生物的制备方法
DE102013008118A1 (de) * 2013-05-11 2014-11-13 Merck Patent Gmbh Arylchinazoline
JP6704422B2 (ja) * 2015-03-20 2020-06-03 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドＣｈｉａ Ｔａｉ Ｔｉａｎｑｉｎｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｇｒｏｕｐ Ｃｏ．，Ｌｔｄ． キナゾリン誘導体の塩およびその製造方法
CN114787151B (zh) * 2019-11-01 2024-04-16 正大天晴药业集团股份有限公司 喹唑啉衍生物或其盐、或其药物组合物的用途
CN114437041B (zh) * 2022-02-25 2023-11-10 湖北科技学院 一类具有抗肿瘤活性的4-四唑基取代-3，4-二氢喹唑啉衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
WO2009057139A2 (en) 2009-05-07
ZA201002807B (en) 2011-07-27
GEP20125603B (en) 2012-08-10
JP2011502141A (ja) 2011-01-20
US20100261740A1 (en) 2010-10-14
AU2008320342A1 (en) 2009-05-07
CA2703767A1 (en) 2009-05-07
CN101878203A (zh) 2010-11-03
AU2008320342A2 (en) 2010-09-02
WO2009057139A3 (en) 2009-09-24
EP2220054A2 (en) 2010-08-25
NZ585357A (en) 2012-02-24
UA101168C2 (ru) 2013-03-11
MX2010004625A (es) 2010-05-20
US8080558B2 (en) 2011-12-20
MY150054A (en) 2013-11-29
AU2008320342B2 (en) 2012-07-26
KR20100087185A (ko) 2010-08-03
EA018716B1 (ru) 2013-10-30

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU