PL2004653T3 - 3-Podstawione N-(arylo- lub heteroarylo)-pirazo[1,5-a]pirymidyny jako inhibitory kinazy - Google Patents
3-Podstawione N-(arylo- lub heteroarylo)-pirazo[1,5-a]pirymidyny jako inhibitory kinazyInfo
- Publication number
- PL2004653T3 PL2004653T3 PL07723895T PL07723895T PL2004653T3 PL 2004653 T3 PL2004653 T3 PL 2004653T3 PL 07723895 T PL07723895 T PL 07723895T PL 07723895 T PL07723895 T PL 07723895T PL 2004653 T3 PL2004653 T3 PL 2004653T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds
- heteroaryl
- aryl
- substituted
- treatment
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 241001465754 Metazoa Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 101100481410 Mus musculus Tek gene Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0606805.0A GB0606805D0 (en) | 2006-04-04 | 2006-04-04 | Organic compounds |
| EP07723895A EP2004653B1 (en) | 2006-04-04 | 2007-04-02 | 3-substituted n-(aryl- or heteroaryl)-pyrazo[1,5-a]pyrimidines as kinase inhibitors |
| PCT/EP2007/002954 WO2007113000A1 (en) | 2006-04-04 | 2007-04-02 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2004653T3 true PL2004653T3 (pl) | 2010-06-30 |
Family
ID=36539336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL07723895T PL2004653T3 (pl) | 2006-04-04 | 2007-04-02 | 3-Podstawione N-(arylo- lub heteroarylo)-pirazo[1,5-a]pirymidyny jako inhibitory kinazy |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090275593A1 (pl) |
| EP (1) | EP2004653B1 (pl) |
| JP (1) | JP2009532401A (pl) |
| KR (1) | KR20090024110A (pl) |
| CN (1) | CN101460500A (pl) |
| AT (1) | ATE453646T1 (pl) |
| AU (1) | AU2007233928A1 (pl) |
| BR (1) | BRPI0710293A2 (pl) |
| CA (1) | CA2646166A1 (pl) |
| DE (1) | DE602007004093D1 (pl) |
| ES (1) | ES2339174T3 (pl) |
| GB (1) | GB0606805D0 (pl) |
| MX (1) | MX2008012820A (pl) |
| PL (1) | PL2004653T3 (pl) |
| PT (1) | PT2004653E (pl) |
| WO (1) | WO2007113000A1 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2350075E (pt) | 2008-09-22 | 2014-06-09 | Array Biopharma Inc | Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase |
| ME03010B (me) | 2008-10-22 | 2018-10-20 | Array Biopharma Inc | Jedinjenja supstituisanog pirazol0[1,5-]pirimidina као inhibitori trk kinaze |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| PL2918588T3 (pl) | 2010-05-20 | 2017-10-31 | Array Biopharma Inc | Związki makrocykliczne jako inhibitory kinazy TRK |
| WO2014081996A1 (en) * | 2012-11-23 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds as diacylglycerol acyltransferase inhibitors |
| TWI767858B (zh) | 2014-11-16 | 2022-06-11 | 美商亞雷生物製藥股份有限公司 | (S)-N-(5-((R)-2-(2,5-二氟苯基)-吡咯啶-1-基)-吡唑并[1,5-a]嘧啶-3-基)-3-羥基吡咯啶-1-甲醯胺硫酸氫鹽結晶型 |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| DK3439662T3 (da) | 2016-04-04 | 2024-09-02 | Loxo Oncology Inc | Væskeformige formuleringer af (s)-n-(5-((r)-2-(2,5-difluorphenyl)-pyrrolidin-1-yl)-pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| EP3458456B1 (en) | 2016-05-18 | 2020-11-25 | Loxo Oncology Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN114751910B (zh) * | 2022-05-17 | 2023-02-24 | 重庆文理学院 | 一种可诱导细胞巨泡式死亡的化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR049769A1 (es) * | 2004-01-22 | 2006-09-06 | Novartis Ag | Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina |
| GB0515026D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
-
2006
- 2006-04-04 GB GBGB0606805.0A patent/GB0606805D0/en not_active Ceased
-
2007
- 2007-04-02 CN CNA2007800206411A patent/CN101460500A/zh active Pending
- 2007-04-02 JP JP2009503472A patent/JP2009532401A/ja active Pending
- 2007-04-02 MX MX2008012820A patent/MX2008012820A/es not_active Application Discontinuation
- 2007-04-02 AT AT07723895T patent/ATE453646T1/de active
- 2007-04-02 PL PL07723895T patent/PL2004653T3/pl unknown
- 2007-04-02 PT PT07723895T patent/PT2004653E/pt unknown
- 2007-04-02 US US12/296,154 patent/US20090275593A1/en not_active Abandoned
- 2007-04-02 BR BRPI0710293-3A patent/BRPI0710293A2/pt not_active IP Right Cessation
- 2007-04-02 CA CA002646166A patent/CA2646166A1/en not_active Abandoned
- 2007-04-02 WO PCT/EP2007/002954 patent/WO2007113000A1/en not_active Ceased
- 2007-04-02 EP EP07723895A patent/EP2004653B1/en active Active
- 2007-04-02 AU AU2007233928A patent/AU2007233928A1/en not_active Abandoned
- 2007-04-02 DE DE602007004093T patent/DE602007004093D1/de not_active Expired - Fee Related
- 2007-04-02 KR KR1020087026941A patent/KR20090024110A/ko not_active Withdrawn
- 2007-04-02 ES ES07723895T patent/ES2339174T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2004653B1 (en) | 2009-12-30 |
| WO2007113000A1 (en) | 2007-10-11 |
| CN101460500A (zh) | 2009-06-17 |
| BRPI0710293A2 (pt) | 2011-08-09 |
| JP2009532401A (ja) | 2009-09-10 |
| CA2646166A1 (en) | 2007-10-11 |
| AU2007233928A1 (en) | 2007-10-11 |
| ES2339174T3 (es) | 2010-05-17 |
| EP2004653A1 (en) | 2008-12-24 |
| US20090275593A1 (en) | 2009-11-05 |
| KR20090024110A (ko) | 2009-03-06 |
| GB0606805D0 (en) | 2006-05-17 |
| ATE453646T1 (de) | 2010-01-15 |
| PT2004653E (pt) | 2010-03-31 |
| MX2008012820A (es) | 2008-10-15 |
| DE602007004093D1 (de) | 2010-02-11 |
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