MX2009006700A - Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas. - Google Patents

Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.

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Publication number
MX2009006700A
MX2009006700A MX2009006700A MX2009006700A MX2009006700A MX 2009006700 A MX2009006700 A MX 2009006700A MX 2009006700 A MX2009006700 A MX 2009006700A MX 2009006700 A MX2009006700 A MX 2009006700A MX 2009006700 A MX2009006700 A MX 2009006700A
Authority
MX
Mexico
Prior art keywords
protein kinase
cyan0
pyrrolo
pyridine
kinase inhibitors
Prior art date
Application number
MX2009006700A
Other languages
English (en)
Inventor
Michael Mortimore
Ronald Knegtel
Guy Brenchley
Steven Durrant
Jean Damien Charrier
Stephen Clinton Young
Simon Robert Lorrie Everitt
Joanne Louise Pinder
Alistair Peter Rutherford
Michael O'donnell
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009006700A publication Critical patent/MX2009006700A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La presente invención se refiere a compuestos útiles como inhibidores de proteína-cinasas. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden estos compuestos y métodos para usar las composiciones en el tratamiento de varias enfermedades, condiciones o trastornos. La invención también proporciona procesos para preparar compuestos de la invención.
MX2009006700A 2006-12-21 2007-12-21 Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas. MX2009006700A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87630706P 2006-12-21 2006-12-21
US92229107P 2007-04-06 2007-04-06
US94770707P 2007-07-03 2007-07-03
US98901407P 2007-11-19 2007-11-19
PCT/US2007/026190 WO2008079346A1 (en) 2006-12-21 2007-12-21 5-cyan0-4- (pyrrolo [2, 3b] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009006700A true MX2009006700A (es) 2009-06-30

Family

ID=39272205

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006700A MX2009006700A (es) 2006-12-21 2007-12-21 Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.

Country Status (13)

Country Link
US (3) US8247421B2 (es)
EP (2) EP2124951B1 (es)
JP (2) JP5406039B2 (es)
KR (1) KR20090091350A (es)
CN (1) CN101678022A (es)
AR (1) AR064675A1 (es)
AU (1) AU2007338754A1 (es)
CA (1) CA2673472A1 (es)
MX (1) MX2009006700A (es)
NO (1) NO20092668L (es)
NZ (1) NZ577798A (es)
TW (1) TW200838517A (es)
WO (1) WO2008079346A1 (es)

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AU2007338754A1 (en) 2008-07-03
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US20100189773A1 (en) 2010-07-29
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