BRPI0408990A - derivados de pirimidin-4-ona e sua utilização como moduladores da p38-cinase - Google Patents

derivados de pirimidin-4-ona e sua utilização como moduladores da p38-cinase

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Publication number
BRPI0408990A
BRPI0408990A BRPI0408990-1A BRPI0408990A BRPI0408990A BR PI0408990 A BRPI0408990 A BR PI0408990A BR PI0408990 A BRPI0408990 A BR PI0408990A BR PI0408990 A BRPI0408990 A BR PI0408990A
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BR
Brazil
Prior art keywords
compounds
derivatives
pyrimidin
kinase modulators
methods
Prior art date
Application number
BRPI0408990-1A
Other languages
English (en)
Inventor
Richard Durley
Balekurdu Devadas
Heather Madsen
Brian Hickory
Katherine Palmquist
Shaun Selness
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0408990A publication Critical patent/BRPI0408990A/pt

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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

"DERIVADOS DE PIRIMIDIN-4-ONA E SUA UTILIZAçãO COMO MODULADORES DA P38-CINASE". São descritos compostos de Fórmula I e sais farmaceuticamente aceitáveis destes, em que R~ 1~, R~ 2~, R~ 4~ e R~ 5~ estão aqui definidos. Estes compostos são úteis para tratar doenças e estados provocados ou exacerbados pela atividade não regulada da p38 MAP cinase e/ou TNF. São também descritas formulações farmacêuticas que contêm os compostos, métodos de preparar os compostos e métodos de tratamento utilizando os compostos.
BRPI0408990-1A 2003-04-03 2004-03-29 derivados de pirimidin-4-ona e sua utilização como moduladores da p38-cinase BRPI0408990A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46012403P 2003-04-03 2003-04-03
PCT/IB2004/001121 WO2004087677A2 (en) 2003-04-03 2004-03-29 Pyrimidin-4-one derivatives and their use as p38 kinase modulators

Publications (1)

Publication Number Publication Date
BRPI0408990A true BRPI0408990A (pt) 2006-04-04

Family

ID=33131912

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408990-1A BRPI0408990A (pt) 2003-04-03 2004-03-29 derivados de pirimidin-4-ona e sua utilização como moduladores da p38-cinase

Country Status (24)

Country Link
US (1) US7183287B2 (pt)
EP (1) EP1753731A2 (pt)
JP (1) JP3981398B1 (pt)
KR (1) KR100776120B1 (pt)
CN (1) CN1968937A (pt)
AP (1) AP2005003403A0 (pt)
AU (1) AU2004226165C1 (pt)
BR (1) BRPI0408990A (pt)
CA (1) CA2521081C (pt)
CR (1) CR8007A (pt)
EA (1) EA009743B1 (pt)
EC (1) ECSP056072A (pt)
GE (1) GEP20074255B (pt)
IS (1) IS8006A (pt)
MA (1) MA27754A1 (pt)
MX (1) MXPA05010621A (pt)
NO (1) NO20055092L (pt)
NZ (1) NZ542139A (pt)
OA (1) OA13113A (pt)
RS (1) RS20050732A (pt)
TN (1) TNSN05250A1 (pt)
UA (1) UA81658C2 (pt)
WO (1) WO2004087677A2 (pt)
ZA (1) ZA200506976B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070167621A1 (en) * 2003-04-03 2007-07-19 Pharmacia Corporation Substituted pyrimidinones
ATE412652T1 (de) 2004-08-12 2008-11-15 Pfizer Triazolopyridinylsulfanylderivate als inhibitoren der p38-map-kinase
EP1802589B1 (en) * 2004-10-13 2014-04-09 Pharmacia & Upjohn Company LLC Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide
WO2006040666A1 (en) * 2004-10-13 2006-04-20 Pharmacia & Upjohn Company Llc Substituted n-alkylpyrimidinones
WO2007081901A2 (en) * 2006-01-05 2007-07-19 The Scripps Research Institute Pyrimidinone derivatives as protein kinase inhibitors
CA2640665A1 (en) * 2006-02-10 2007-08-16 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PL3026044T3 (pl) 2006-06-26 2019-04-30 Akebia Therapeutics Inc Inhibitory prolilo-hydroksylazy i sposoby ich użycia
EP2383259A1 (en) 2006-08-25 2011-11-02 Boehringer Ingelheim International GmbH New pyridone derivatives with MCH antagonistic activity and medicaments comprising these compounds
WO2008071646A1 (en) 2006-12-11 2008-06-19 Boehringer Ingelheim International Gmbh New pyridazine derivatives with mch antagonistic activity and medicaments comprising these compounds
TW200845994A (en) * 2007-01-12 2008-12-01 Smithkline Beecham Corp N-substituted glycine derivatives: prolyl hydroxylase inhibitors
WO2008153942A1 (en) * 2007-06-06 2008-12-18 Xcovery, Inc. Kinase inhibitor compounds
WO2010138585A1 (en) * 2009-05-29 2010-12-02 Merck Sharp & Dohme Corp. Pyrimidinones as pde10 inhibitors
EP2649998B1 (en) * 2009-11-06 2015-03-04 Aerpio Therapeutics Inc. Prolyl hydroxylase inhibitors
US8507499B2 (en) 2010-12-06 2013-08-13 Confluence Life Sciences, Inc. Substituted indole/indazole-pyrimidinyl compounds
PL2648516T3 (pl) 2010-12-06 2019-04-30 Aclaris Therapeutics Inc Podstawione związki pirydynono-pirydynylowe
WO2012078673A1 (en) 2010-12-06 2012-06-14 Confluence Life Sciences, Inc. Substituted pyridine urea compounds
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
NO2686520T3 (pt) 2011-06-06 2018-03-17
MX2014000536A (es) 2011-07-13 2014-12-05 Novartis Ag Compuestos de 4-piperidinilo para usarse como inhibidores de tanquirasa.
JP2014520860A (ja) 2011-07-13 2014-08-25 ノバルティス アーゲー タンキラーゼ阻害剤として使用するための４−オキソ−３，５，７，８−テトラヒドロ−４Ｈ−ピラノ｛４，３−ｄ｝ピルミニジニル化合物
WO2013012723A1 (en) 2011-07-13 2013-01-24 Novartis Ag Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
US9056110B2 (en) 2011-12-06 2015-06-16 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
US9365540B2 (en) 2012-01-12 2016-06-14 Takeda Pharmaceutical Company Limited Benzimidazole derivatives as MCH receptor antagonists
US9434695B2 (en) 2012-07-18 2016-09-06 Sunshine Lake Pharma Co., Ltd Nitrogenous heterocyclic derivatives and their application in drugs
DK3003039T3 (da) 2013-06-07 2021-05-25 Aclaris Therapeutics Inc Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser
DK3007695T3 (da) 2013-06-13 2024-03-18 Akebia Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af anæmi
HRP20220096T1 (hr) 2014-05-01 2022-04-15 Celgene Quanticel Research, Inc. Inhibitori lizin specifične demetilaze-1
US9981920B2 (en) 2014-06-26 2018-05-29 Rodin Therapeutics, Inc. Inhibitors of histone deacetylase
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
BR112017015852A2 (pt) 2015-01-23 2018-03-27 Akebia Therapeutics Inc forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1
HRP20211862T1 (hr) 2015-04-01 2022-03-04 Akebia Therapeutics, Inc. Pripravci za i postupci liječenja anemije
AR114886A1 (es) 2018-05-09 2020-10-28 Akebia Therapeutics Inc Proceso para preparar ácido 2-[[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino]acético
GB201820450D0 (en) 2018-12-14 2019-01-30 Z Factor Ltd Compound and its use for the treatment of alpha1-antitryspin deficiency
JP2023519890A (ja) 2020-03-27 2023-05-15 アクラリス セラピューティクス，インコーポレイテッド 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物
CN112209886A (zh) * 2020-11-09 2021-01-12 沈阳药科大学 2-(3-氰基-4-烷氧基)苯基嘧啶衍生物及其制备方法和用途
EP4313970A1 (en) 2021-03-31 2024-02-07 Xinthera, Inc. Mk2 inhibitors and uses thereof
EP4367099A1 (en) 2021-07-09 2024-05-15 Xinthera, Inc. Pyridinone mk2 inhibitors and uses thereof
WO2023248964A1 (ja) * 2022-06-21 2023-12-28 クミアイ化学工業株式会社 ハロ酢酸を用いたスルホン誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61205261A (ja) * 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
AU7798994A (en) * 1993-10-20 1995-05-08 Upjohn Company, The Pyrimidinones as antiarthritic and anti-inflammatories
NZ335992A (en) * 1996-12-05 2001-09-28 Amgen Inc Substituted pyrimidinone and pyridone compounds and methods of use
WO1999064400A1 (en) * 1998-06-12 1999-12-16 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
AU2247701A (en) * 1999-10-21 2001-04-30 Merck & Co., Inc. Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment
DE60313350T2 (de) * 2002-08-13 2008-01-03 Warner-Lambert Company Llc Pyrimidin-2,4-dion-derivate als matrix-metalloproteinase-hemmer

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