AP2005003403A0 - Substituted pyrimidinones. - Google Patents
Substituted pyrimidinones.Info
- Publication number
- AP2005003403A0 AP2005003403A0 AP2005003403A AP2005003403A AP2005003403A0 AP 2005003403 A0 AP2005003403 A0 AP 2005003403A0 AP 2005003403 A AP2005003403 A AP 2005003403A AP 2005003403 A AP2005003403 A AP 2005003403A AP 2005003403 A0 AP2005003403 A0 AP 2005003403A0
- Authority
- AP
- ARIPO
- Prior art keywords
- substituted pyrimidinones
- pyrimidinones
- substituted
- Prior art date
Links
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46012403P | 2003-04-03 | 2003-04-03 | |
PCT/IB2004/001121 WO2004087677A2 (en) | 2003-04-03 | 2004-03-29 | Pyrimidin-4-one derivatives and their use as p38 kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2005003403A0 true AP2005003403A0 (en) | 2005-12-31 |
Family
ID=33131912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2005003403A AP2005003403A0 (en) | 2003-04-03 | 2004-03-29 | Substituted pyrimidinones. |
Country Status (24)
Country | Link |
---|---|
US (1) | US7183287B2 (xx) |
EP (1) | EP1753731A2 (xx) |
JP (1) | JP3981398B1 (xx) |
KR (1) | KR100776120B1 (xx) |
CN (1) | CN1968937A (xx) |
AP (1) | AP2005003403A0 (xx) |
AU (1) | AU2004226165C1 (xx) |
BR (1) | BRPI0408990A (xx) |
CA (1) | CA2521081C (xx) |
CR (1) | CR8007A (xx) |
EA (1) | EA009743B1 (xx) |
EC (1) | ECSP056072A (xx) |
GE (1) | GEP20074255B (xx) |
IS (1) | IS8006A (xx) |
MA (1) | MA27754A1 (xx) |
MX (1) | MXPA05010621A (xx) |
NO (1) | NO20055092L (xx) |
NZ (1) | NZ542139A (xx) |
OA (1) | OA13113A (xx) |
RS (1) | RS20050732A (xx) |
TN (1) | TNSN05250A1 (xx) |
UA (1) | UA81658C2 (xx) |
WO (1) | WO2004087677A2 (xx) |
ZA (1) | ZA200506976B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070167621A1 (en) * | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
JP4084836B2 (ja) | 2004-08-12 | 2008-04-30 | ファイザー・インク | p38MAPキナーゼインヒビターとしてのトリアゾロピリジニルスルファニル誘導体 |
MX2007004493A (es) * | 2004-10-13 | 2007-05-08 | Upjohn Co | N-alquilpirimidinonas sustituidas. |
EP1802589B1 (en) * | 2004-10-13 | 2014-04-09 | Pharmacia & Upjohn Company LLC | Crystalline forms of 3-[5-chloro-4-[(2,4-difluorobenzyl) oxy]-6-oxopyrimidin-1(6h)-yl]-n-(2-hydroxyethyl)-4-methylbenzamide |
WO2007081901A2 (en) * | 2006-01-05 | 2007-07-19 | The Scripps Research Institute | Pyrimidinone derivatives as protein kinase inhibitors |
EP1987022A1 (en) * | 2006-02-10 | 2008-11-05 | Pfizer Products Inc. | Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives |
US7588924B2 (en) * | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
KR101130592B1 (ko) * | 2006-06-26 | 2012-04-02 | 워너 칠콧 컴퍼니 엘엘씨 | 프롤릴 히드록실라제 저해제 및 사용 방법 |
JP5073746B2 (ja) | 2006-08-25 | 2012-11-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Mch拮抗作用を有する新規ピリドン誘導体及びこの化合物を含む薬物 |
JP2010512366A (ja) | 2006-12-11 | 2010-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Mch拮抗活性を有する新規ピリダジン誘導体及びこれらの化合物を含む薬物 |
CL2008000065A1 (es) * | 2007-01-12 | 2008-09-22 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituida, inhibidores de hif prolil hidroxilasas; su proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anemia. |
WO2008153942A1 (en) * | 2007-06-06 | 2008-12-18 | Xcovery, Inc. | Kinase inhibitor compounds |
WO2010138585A1 (en) * | 2009-05-29 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pyrimidinones as pde10 inhibitors |
MX2012005273A (es) | 2009-11-06 | 2012-06-19 | Aerpio Therapeutics Inc | Metodos para incrementar la estabilizacion de factor-1 alfa inducible por hipoxia. |
PL2648516T3 (pl) | 2010-12-06 | 2019-04-30 | Aclaris Therapeutics Inc | Podstawione związki pirydynono-pirydynylowe |
US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
US8507499B2 (en) | 2010-12-06 | 2013-08-13 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
NO2686520T3 (xx) | 2011-06-06 | 2018-03-17 | ||
EP2731942B1 (en) | 2011-07-13 | 2015-09-23 | Novartis AG | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
EP2731951B1 (en) | 2011-07-13 | 2015-08-19 | Novartis AG | 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors |
JP5957077B2 (ja) | 2011-07-13 | 2016-07-27 | ノバルティス アーゲー | タンキラーゼ阻害剤として使用するための4−ピペリジニル化合物 |
WO2013086208A1 (en) | 2011-12-06 | 2013-06-13 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
JP6129850B2 (ja) * | 2012-01-12 | 2017-05-17 | 武田薬品工業株式会社 | Mch受容体拮抗剤としてのベンゾイミダゾール誘導体 |
AU2013292950C1 (en) | 2012-07-18 | 2016-01-21 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
CA2917344C (en) | 2013-06-07 | 2021-09-07 | Confluence Life Sciences, Inc. | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
NZ753904A (en) | 2013-06-13 | 2020-07-31 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
SG11201609033TA (en) | 2014-05-01 | 2016-11-29 | Celgene Quanticel Res Inc | Inhibitors of lysine specific demethylase-1 |
US9981920B2 (en) | 2014-06-26 | 2018-05-29 | Rodin Therapeutics, Inc. | Inhibitors of histone deacetylase |
AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
EP3247355A4 (en) | 2015-01-23 | 2018-06-13 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
LT3277270T (lt) | 2015-04-01 | 2022-01-10 | Akebia Therapeutics, Inc. | Kompozicijos ir būdai skirti anemijos gydymui |
MX2020011845A (es) | 2018-05-09 | 2021-01-15 | Akebia Therapeutics Inc | Proceso para preparar acido 2-[[5-(3-clorofenil)-3-hidroxipiridina -2-carbonil]amino]acetico. |
GB201820450D0 (en) | 2018-12-14 | 2019-01-30 | Z Factor Ltd | Compound and its use for the treatment of alpha1-antitryspin deficiency |
JP2023519890A (ja) | 2020-03-27 | 2023-05-15 | アクラリス セラピューティクス,インコーポレイテッド | 免疫状態の処置のためのmk2経路阻害剤の経口組成物 |
CN112209886A (zh) * | 2020-11-09 | 2021-01-12 | 沈阳药科大学 | 2-(3-氰基-4-烷氧基)苯基嘧啶衍生物及其制备方法和用途 |
JP2024512154A (ja) | 2021-03-31 | 2024-03-18 | シンセラ, インコーポレイテッド | Mk2阻害剤及びその使用 |
EP4367099A1 (en) | 2021-07-09 | 2024-05-15 | Xinthera, Inc. | Pyridinone mk2 inhibitors and uses thereof |
WO2023248964A1 (ja) * | 2022-06-21 | 2023-12-28 | クミアイ化学工業株式会社 | ハロ酢酸を用いたスルホン誘導体の製造方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61205261A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | 6―置換―5―フルオロウラシル誘導体 |
WO1995011235A1 (en) * | 1993-10-20 | 1995-04-27 | The Upjohn Company | Pyrimidinones as antiarthritic and anti-inflammatories |
IL130181A0 (en) * | 1996-12-05 | 2000-06-01 | Amgen Inc | Substituted pyrimidone and pyridone compounds and methods of use |
JP2002517486A (ja) * | 1998-06-12 | 2002-06-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | p38のインヒビター |
AU2247701A (en) * | 1999-10-21 | 2001-04-30 | Merck & Co., Inc. | Gram-positive selective antibacterial compounds, compositions containing such compounds and methods of treatment |
MXPA05001783A (es) * | 2002-08-13 | 2005-04-25 | Warner Lambert Co | Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz. |
-
2004
- 2004-03-24 US US10/808,146 patent/US7183287B2/en not_active Expired - Fee Related
- 2004-03-29 AU AU2004226165A patent/AU2004226165C1/en not_active Ceased
- 2004-03-29 NZ NZ542139A patent/NZ542139A/en unknown
- 2004-03-29 WO PCT/IB2004/001121 patent/WO2004087677A2/en active Application Filing
- 2004-03-29 JP JP2006506466A patent/JP3981398B1/ja not_active Expired - Fee Related
- 2004-03-29 KR KR1020057018627A patent/KR100776120B1/ko not_active IP Right Cessation
- 2004-03-29 AP AP2005003403A patent/AP2005003403A0/xx unknown
- 2004-03-29 UA UAA200508500A patent/UA81658C2/ru unknown
- 2004-03-29 RS YUP-2005/0732A patent/RS20050732A/sr unknown
- 2004-03-29 BR BRPI0408990-1A patent/BRPI0408990A/pt not_active IP Right Cessation
- 2004-03-29 EP EP04724083A patent/EP1753731A2/en not_active Withdrawn
- 2004-03-29 OA OA1200500271A patent/OA13113A/en unknown
- 2004-03-29 CN CNA2004800156300A patent/CN1968937A/zh active Pending
- 2004-03-29 CA CA2521081A patent/CA2521081C/en not_active Expired - Fee Related
- 2004-03-29 GE GEAP20049005A patent/GEP20074255B/en unknown
- 2004-03-29 MX MXPA05010621A patent/MXPA05010621A/es active IP Right Grant
- 2004-03-29 EA EA200501332A patent/EA009743B1/ru unknown
-
2005
- 2005-08-29 IS IS8006A patent/IS8006A/is unknown
- 2005-08-31 ZA ZA200506976A patent/ZA200506976B/en unknown
- 2005-09-27 CR CR8007A patent/CR8007A/es not_active Application Discontinuation
- 2005-10-03 MA MA28531A patent/MA27754A1/fr unknown
- 2005-10-03 EC EC2005006072A patent/ECSP056072A/es unknown
- 2005-10-03 TN TNP2005000250A patent/TNSN05250A1/fr unknown
- 2005-11-01 NO NO20055092A patent/NO20055092L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA05010621A (es) | 2005-11-23 |
NZ542139A (en) | 2008-11-28 |
US7183287B2 (en) | 2007-02-27 |
US20040242608A1 (en) | 2004-12-02 |
CN1968937A (zh) | 2007-05-23 |
TNSN05250A1 (fr) | 2007-07-10 |
NO20055092L (no) | 2005-11-01 |
JP3981398B1 (ja) | 2007-09-26 |
RS20050732A (xx) | 2007-08-03 |
MA27754A1 (fr) | 2006-02-01 |
EA200501332A1 (ru) | 2006-06-30 |
ECSP056072A (es) | 2006-03-01 |
KR20060006906A (ko) | 2006-01-20 |
BRPI0408990A (pt) | 2006-04-04 |
JP2007528353A (ja) | 2007-10-11 |
WO2004087677A3 (en) | 2004-12-16 |
OA13113A (en) | 2006-11-10 |
AU2004226165A1 (en) | 2004-10-14 |
GEP20074255B (en) | 2007-12-10 |
UA81658C2 (xx) | 2008-01-25 |
EA009743B1 (ru) | 2008-04-28 |
IS8006A (is) | 2005-08-29 |
KR100776120B1 (ko) | 2007-11-16 |
ZA200506976B (en) | 2006-10-25 |
CA2521081A1 (en) | 2004-10-14 |
WO2004087677A2 (en) | 2004-10-14 |
EP1753731A2 (en) | 2007-02-21 |
AU2004226165B2 (en) | 2007-11-08 |
AU2004226165C1 (en) | 2008-07-03 |
AU2004226165A2 (en) | 2004-10-14 |
CR8007A (es) | 2006-02-13 |
CA2521081C (en) | 2010-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AP2005003403A0 (en) | Substituted pyrimidinones. | |
EG25273A (en) | Substituted dihydroquinazolines. | |
EG24843A (en) | Herbicidal pyrimidines | |
EP1546115A4 (en) | SUBSTITUTED PYRIMIDINES | |
ZA200603879B (en) | Substituted indazole-O-glucosides | |
IL175490A0 (en) | Substituted indazole-o-glucosides | |
ZA200603880B (en) | Substituted indole-O-glucosides | |
EP1680131A4 (en) | SUBSTITUTED INDOLE-O-GLUCOSIDES | |
ZA200400386B (en) | Attachment element. | |
ZA200600430B (en) | Substituted spirobenzazepines | |
AP2157A (en) | 2-substituted pyrimidines. | |
AP2006003496A0 (en) | 2-Substituted pyrimidines. | |
LU91022B1 (en) | Sektionaltor. | |
GB0315045D0 (en) | Dual.L | |
TJ391B (en) | Medicinal-preventive biopreparation subtilben. | |
EG23241A (en) | Beshob. | |
ZA200408404B (en) | Securing means. | |
ZA200402256B (en) | Down-the-hole-drill assembly. | |
GB0315839D0 (en) | www.wereuthe1.com | |
ZA200408169B (en) | Imidazolinylmethyl aralkylsulfonamides. | |
MXPA02001688A (es) | Marco facil. | |
MXPA02003350A (es) | Calentador-tanque-termo-solar. | |
ZA200302985B (en) | Securing means. | |
ZA200308621B (en) | Construction element. | |
GB0307972D0 (en) | E.b.o.e.s.s |