EA200501332A1 - Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38 - Google Patents

Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38

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Publication number
EA200501332A1
EA200501332A1 EA200501332A EA200501332A EA200501332A1 EA 200501332 A1 EA200501332 A1 EA 200501332A1 EA 200501332 A EA200501332 A EA 200501332A EA 200501332 A EA200501332 A EA 200501332A EA 200501332 A1 EA200501332 A1 EA 200501332A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
kinaza
pyrimidin
modulators
derivatives
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EA200501332A
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English (en)
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EA009743B1 (ru
Inventor
Ричард Дерли
Балекудру Дивадас
Хизер Мэдсен
Брайан Хикори
Катерин Палмквист
Шон Селнесс
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Фармация Корпорейшн
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Publication of EA200501332A1 publication Critical patent/EA200501332A1/ru
Publication of EA009743B1 publication Critical patent/EA009743B1/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Описаны соединения формулы I и их фармацевтически приемлемые соли, где R, R, Rи Rтакие, как они определены в данном описании. Данные соединения полезны для лечения заболеваний и состояний, вызванных или осложненных нерегулируемой активностью МАР-киназы р38 и/или TNF. Также описаны фармацевтические композиции, содержащие данные соединения, способы получения данных соединений и способы лечения с использованием данных соединений.
EA200501332A 2003-04-03 2004-03-29 Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38 EA009743B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46012403P 2003-04-03 2003-04-03
PCT/IB2004/001121 WO2004087677A2 (en) 2003-04-03 2004-03-29 Pyrimidin-4-one derivatives and their use as p38 kinase modulators

Publications (2)

Publication Number Publication Date
EA200501332A1 true EA200501332A1 (ru) 2006-06-30
EA009743B1 EA009743B1 (ru) 2008-04-28

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EA200501332A EA009743B1 (ru) 2003-04-03 2004-03-29 Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38

Country Status (24)

Country Link
US (1) US7183287B2 (ru)
EP (1) EP1753731A2 (ru)
JP (1) JP3981398B1 (ru)
KR (1) KR100776120B1 (ru)
CN (1) CN1968937A (ru)
AP (1) AP2005003403A0 (ru)
AU (1) AU2004226165C1 (ru)
BR (1) BRPI0408990A (ru)
CA (1) CA2521081C (ru)
CR (1) CR8007A (ru)
EA (1) EA009743B1 (ru)
EC (1) ECSP056072A (ru)
GE (1) GEP20074255B (ru)
IS (1) IS8006A (ru)
MA (1) MA27754A1 (ru)
MX (1) MXPA05010621A (ru)
NO (1) NO20055092L (ru)
NZ (1) NZ542139A (ru)
OA (1) OA13113A (ru)
RS (1) RS20050732A (ru)
TN (1) TNSN05250A1 (ru)
UA (1) UA81658C2 (ru)
WO (1) WO2004087677A2 (ru)
ZA (1) ZA200506976B (ru)

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