AP2005003403A0 - Substituted pyrimidinones. - Google Patents
Substituted pyrimidinones.Info
- Publication number
- AP2005003403A0 AP2005003403A0 AP2005003403A AP2005003403A AP2005003403A0 AP 2005003403 A0 AP2005003403 A0 AP 2005003403A0 AP 2005003403 A AP2005003403 A AP 2005003403A AP 2005003403 A AP2005003403 A AP 2005003403A AP 2005003403 A0 AP2005003403 A0 AP 2005003403A0
- Authority
- AP
- ARIPO
- Prior art keywords
- substituted pyrimidinones
- pyrimidinones
- substituted
- Prior art date
Links
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical class OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46012403P | 2003-04-03 | 2003-04-03 | |
PCT/IB2004/001121 WO2004087677A2 (en) | 2003-04-03 | 2004-03-29 | Pyrimidin-4-one derivatives and their use as p38 kinase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2005003403A0 true AP2005003403A0 (en) | 2005-12-31 |
Family
ID=33131912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2005003403A AP2005003403A0 (en) | 2003-04-03 | 2004-03-29 | Substituted pyrimidinones. |
Country Status (24)
Country | Link |
---|---|
US (1) | US7183287B2 (ru) |
EP (1) | EP1753731A2 (ru) |
JP (1) | JP3981398B1 (ru) |
KR (1) | KR100776120B1 (ru) |
CN (1) | CN1968937A (ru) |
AP (1) | AP2005003403A0 (ru) |
AU (1) | AU2004226165C1 (ru) |
BR (1) | BRPI0408990A (ru) |
CA (1) | CA2521081C (ru) |
CR (1) | CR8007A (ru) |
EA (1) | EA009743B1 (ru) |
EC (1) | ECSP056072A (ru) |
GE (1) | GEP20074255B (ru) |
IS (1) | IS8006A (ru) |
MA (1) | MA27754A1 (ru) |
MX (1) | MXPA05010621A (ru) |
NO (1) | NO20055092L (ru) |
NZ (1) | NZ542139A (ru) |
OA (1) | OA13113A (ru) |
RS (1) | RS20050732A (ru) |
TN (1) | TNSN05250A1 (ru) |
UA (1) | UA81658C2 (ru) |
WO (1) | WO2004087677A2 (ru) |
ZA (1) | ZA200506976B (ru) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070167621A1 (en) * | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
EP1778686B9 (en) | 2004-08-12 | 2009-07-08 | Pfizer Limited | Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors |
JP4937129B2 (ja) * | 2004-10-13 | 2012-05-23 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 3−[5−クロロ−4−[(2,4−ジフルオロベンジル)オキシ]−6−オキソピリミジン−1(6h)−イル]−n−(2−ヒドロキシエチル)−4−メチルベンズアミドの結晶形 |
JP2008515964A (ja) * | 2004-10-13 | 2008-05-15 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 置換n−アルキルピリミジノン |
WO2007081901A2 (en) * | 2006-01-05 | 2007-07-19 | The Scripps Research Institute | Pyrimidinone derivatives as protein kinase inhibitors |
JP2009526039A (ja) * | 2006-02-10 | 2009-07-16 | ファイザー・プロダクツ・インク | ピリジノンピラゾール尿素およびピリミジノンピラゾール尿素誘導体 |
US7588924B2 (en) * | 2006-03-07 | 2009-09-15 | Procter & Gamble Company | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase |
US7811595B2 (en) | 2006-06-26 | 2010-10-12 | Warner Chilcott Company, Llc | Prolyl hydroxylase inhibitors and methods of use |
WO2008022979A1 (en) | 2006-08-25 | 2008-02-28 | Boehringer Ingelheim International Gmbh | New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds |
CL2007003580A1 (es) | 2006-12-11 | 2009-03-27 | Boehringer Ingelheim Int | Compuestos derivados de piridazina, antagonistas de mch; composicion farmaceutica que comprende a dicho compuesto; procedimiento de preparacion; y uso del compuesto en el tratamiento de trastornos metabolicos y/o trastornos alimentarios como obesidad, bulimia, anorexia, hiperfagia, diabetes. |
CL2008000065A1 (es) * | 2007-01-12 | 2008-09-22 | Smithkline Beecham Corp | Compuestos derivados de glicina n-sustituida, inhibidores de hif prolil hidroxilasas; su proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anemia. |
JP2010529129A (ja) * | 2007-06-06 | 2010-08-26 | タイロジェネックス,インコーポレイテッド | キナーゼ阻害剤化合物 |
WO2010138585A1 (en) * | 2009-05-29 | 2010-12-02 | Merck Sharp & Dohme Corp. | Pyrimidinones as pde10 inhibitors |
WO2011057112A1 (en) | 2009-11-06 | 2011-05-12 | Akebia Therapeutics Inc. | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha |
PT2648516T (pt) | 2010-12-06 | 2018-11-29 | Aclaris Therapeutics Inc | Compostos de piridinona-piridinilo substituídos |
US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
WO2012078674A1 (en) | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
NO2686520T3 (ru) | 2011-06-06 | 2018-03-17 | ||
JP2014520858A (ja) | 2011-07-13 | 2014-08-25 | ノバルティス アーゲー | タンキラーゼ阻害剤として用いるための新規な2−ピペリジン−1−イル−アセトアミド化合物 |
ES2548513T3 (es) | 2011-07-13 | 2015-10-19 | Novartis Ag | Compuestos de 4-piperidinilo para uso como inhibidores de tankirasa |
EP2731951B1 (en) | 2011-07-13 | 2015-08-19 | Novartis AG | 4-oxo-3,5,7,8-tetrahydro-4h-pyrano {4,3-d} pyrminidinyl compounds for use as tankyrase inhibitors |
US9056110B2 (en) | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
US9365540B2 (en) | 2012-01-12 | 2016-06-14 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as MCH receptor antagonists |
BR112014030284B1 (pt) * | 2012-07-18 | 2021-11-30 | Sunshine Lake Pharma Co., Ltd | Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica |
CN108478579B (zh) | 2013-06-07 | 2021-05-25 | 阿克拉里斯医疗股份有限公司 | 吡啶酮-吡啶基化合物及其用途 |
SI3007695T1 (sl) | 2013-06-13 | 2024-04-30 | Akebia Therapeutics, Inc. | Sestavki in metode za zdravljenje anemije |
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JPS61205261A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | 6―置換―5―フルオロウラシル誘導体 |
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- 2004-03-29 EP EP04724083A patent/EP1753731A2/en not_active Withdrawn
- 2004-03-29 UA UAA200508500A patent/UA81658C2/ru unknown
- 2004-03-29 RS YUP-2005/0732A patent/RS20050732A/sr unknown
- 2004-03-29 CA CA2521081A patent/CA2521081C/en not_active Expired - Fee Related
- 2004-03-29 WO PCT/IB2004/001121 patent/WO2004087677A2/en active Application Filing
- 2004-03-29 AP AP2005003403A patent/AP2005003403A0/xx unknown
- 2004-03-29 JP JP2006506466A patent/JP3981398B1/ja not_active Expired - Fee Related
- 2004-03-29 AU AU2004226165A patent/AU2004226165C1/en not_active Ceased
- 2004-03-29 MX MXPA05010621A patent/MXPA05010621A/es active IP Right Grant
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- 2004-03-29 KR KR1020057018627A patent/KR100776120B1/ko not_active IP Right Cessation
- 2004-03-29 NZ NZ542139A patent/NZ542139A/en unknown
- 2004-03-29 CN CNA2004800156300A patent/CN1968937A/zh active Pending
- 2004-03-29 OA OA1200500271A patent/OA13113A/en unknown
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- 2004-03-29 EA EA200501332A patent/EA009743B1/ru unknown
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- 2005-09-27 CR CR8007A patent/CR8007A/es not_active Application Discontinuation
- 2005-10-03 EC EC2005006072A patent/ECSP056072A/es unknown
- 2005-10-03 MA MA28531A patent/MA27754A1/fr unknown
- 2005-10-03 TN TNP2005000250A patent/TNSN05250A1/fr unknown
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EA009743B1 (ru) | 2008-04-28 |
NO20055092L (no) | 2005-11-01 |
OA13113A (en) | 2006-11-10 |
BRPI0408990A (pt) | 2006-04-04 |
KR20060006906A (ko) | 2006-01-20 |
UA81658C2 (en) | 2008-01-25 |
EA200501332A1 (ru) | 2006-06-30 |
AU2004226165C1 (en) | 2008-07-03 |
EP1753731A2 (en) | 2007-02-21 |
JP2007528353A (ja) | 2007-10-11 |
KR100776120B1 (ko) | 2007-11-16 |
CA2521081C (en) | 2010-09-07 |
MXPA05010621A (es) | 2005-11-23 |
JP3981398B1 (ja) | 2007-09-26 |
NZ542139A (en) | 2008-11-28 |
WO2004087677A3 (en) | 2004-12-16 |
US7183287B2 (en) | 2007-02-27 |
ZA200506976B (en) | 2006-10-25 |
CA2521081A1 (en) | 2004-10-14 |
US20040242608A1 (en) | 2004-12-02 |
TNSN05250A1 (fr) | 2007-07-10 |
WO2004087677A2 (en) | 2004-10-14 |
MA27754A1 (fr) | 2006-02-01 |
GEP20074255B (en) | 2007-12-10 |
AU2004226165A2 (en) | 2004-10-14 |
IS8006A (is) | 2005-08-29 |
ECSP056072A (es) | 2006-03-01 |
CR8007A (es) | 2006-02-13 |
AU2004226165B2 (en) | 2007-11-08 |
RS20050732A (en) | 2007-08-03 |
CN1968937A (zh) | 2007-05-23 |
AU2004226165A1 (en) | 2004-10-14 |
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