DK3003039T3 - Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser - Google Patents
Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser Download PDFInfo
- Publication number
- DK3003039T3 DK3003039T3 DK14808115.1T DK14808115T DK3003039T3 DK 3003039 T3 DK3003039 T3 DK 3003039T3 DK 14808115 T DK14808115 T DK 14808115T DK 3003039 T3 DK3003039 T3 DK 3003039T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridinyl
- pyridinon
- metoxy
- fluor
- substituted
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832736P | 2013-06-07 | 2013-06-07 | |
| PCT/US2014/041381 WO2014197846A1 (en) | 2013-06-07 | 2014-06-06 | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3003039T3 true DK3003039T3 (da) | 2021-05-25 |
Family
ID=52005972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14808115.1T DK3003039T3 (da) | 2013-06-07 | 2014-06-06 | Methyl/fluor-pyridinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser og fluor-pyrimidinyl-metoxy-substituerede pyridinon-pyridinyl-forbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9115089B2 (da) |
| EP (2) | EP3003039B1 (da) |
| JP (4) | JP6699909B2 (da) |
| KR (3) | KR102470598B1 (da) |
| CN (2) | CN105263326B (da) |
| CA (1) | CA2917344C (da) |
| CY (1) | CY1124222T1 (da) |
| DK (1) | DK3003039T3 (da) |
| ES (1) | ES2869048T3 (da) |
| HR (1) | HRP20210813T1 (da) |
| HU (1) | HUE054178T2 (da) |
| LT (1) | LT3003039T (da) |
| PL (1) | PL3003039T3 (da) |
| PT (1) | PT3003039T (da) |
| RS (1) | RS61724B1 (da) |
| SI (1) | SI3003039T1 (da) |
| WO (1) | WO2014197846A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2869048T3 (es) * | 2013-06-07 | 2021-10-22 | Aclaris Therapeutics Inc | Compuestos de piridinona-piridinilo sustituidos con metil/fluoro-piridinil-metoxi y compuestos de piridinona-piridinilo sustituidos con fluoro-pirimidinil-metoxi |
| EP3502692A1 (en) | 2017-12-20 | 2019-06-26 | Aposcience AG | Potency assay for secretomes |
| KR20220041180A (ko) * | 2019-07-31 | 2022-03-31 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 중소수화 mk2 경로 억제제 및 이를 이용하는 방법 |
| EP4125891A1 (en) | 2020-03-27 | 2023-02-08 | Aclaris Therapeutics, Inc. | Process, compositions, and crystalline forms of substituted pyridinone-pyridinyl compounds |
| IL303028A (en) * | 2020-11-23 | 2023-07-01 | Aclaris Therapeutics Inc | Methods for the synthesis of substituted pyridinone-pyridinyl compounds |
| EP4313970A1 (en) | 2021-03-31 | 2024-02-07 | Xinthera, Inc. | Mk2 inhibitors and uses thereof |
| AU2022307534A1 (en) | 2021-07-09 | 2024-02-22 | Xinthera, Inc. | Pyridinone mk2 inhibitors and uses thereof |
| WO2023001282A1 (zh) * | 2021-07-23 | 2023-01-26 | 南京明德新药研发有限公司 | 杂环取代的嘧啶衍生物 |
| TW202315625A (zh) * | 2021-08-13 | 2023-04-16 | 大陸商深圳信立泰藥業股份有限公司 | 三聯吡啶二酮化合物或其鹽、包括其藥物組合物及其用途 |
| WO2023125708A1 (zh) * | 2021-12-29 | 2023-07-06 | 上海美悦生物科技发展有限公司 | 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途 |
| CN116444492A (zh) * | 2021-12-29 | 2023-07-18 | 上海美悦生物科技发展有限公司 | 一种p38 MAPK/MK2通路调节剂及其组合物、制备方法和用途 |
| WO2023134765A1 (zh) * | 2022-01-14 | 2023-07-20 | 上海翰森生物医药科技有限公司 | 含五元环类衍生物、其制备方法和应用 |
| WO2023150709A2 (en) * | 2022-02-04 | 2023-08-10 | Aclaris Therapeutics, Inc. | Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds |
| WO2023165554A1 (zh) * | 2022-03-03 | 2023-09-07 | 深圳信立泰药业股份有限公司 | 一种氘代三联吡啶二酮化合物或其盐及其制备方法与应用 |
| CN115057811A (zh) * | 2022-05-26 | 2022-09-16 | 安庆朗坤药业有限公司 | 一种2-溴甲基-3,5-二氟吡啶的制备方法 |
| WO2024022412A1 (zh) * | 2022-07-28 | 2024-02-01 | 深圳信立泰药业股份有限公司 | 一种式(i)所示的三联吡啶二酮化合物晶型及其制备方法与应用 |
| WO2024046327A1 (zh) * | 2022-08-30 | 2024-03-07 | 长春金赛药业有限责任公司 | p38α-MK2抑制剂化合物、药物组合物及其应用 |
| WO2024077059A1 (en) * | 2022-10-05 | 2024-04-11 | Xinthera, Inc. | Crystalline forms of an mk2 inhibitor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US789061A (en) * | 1904-07-11 | 1905-05-02 | Harrison G Post | Paper barrel. |
| JP2002526482A (ja) | 1998-09-18 | 2002-08-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｐ３８のインヒビター |
| NZ515285A (en) | 1999-05-21 | 2004-01-30 | Scios Inc | Indole-type derivatives as inhibitors of p38 kinase |
| WO2002042292A2 (en) | 2000-11-20 | 2002-05-30 | Scios Inc. | Indol derivative and their use as inhibitors of p38 kinase |
| US7314752B2 (en) | 2001-07-19 | 2008-01-01 | Common Sense, Ltd. | Secretion-monitoring article |
| DE60330126D1 (de) | 2002-02-14 | 2009-12-31 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| GB0218630D0 (en) | 2002-08-10 | 2002-09-18 | Tanabe Seiyaku Co | Novel compounds |
| WO2004024078A2 (en) | 2002-09-11 | 2004-03-25 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors |
| US20070167621A1 (en) | 2003-04-03 | 2007-07-19 | Pharmacia Corporation | Substituted pyrimidinones |
| US7183287B2 (en) | 2003-04-03 | 2007-02-27 | Pharmacia Corporation | Substituted pyrimidinones |
| CL2004002050A1 (es) | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
| JP2005255675A (ja) | 2004-02-09 | 2005-09-22 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| BRPI0507628A (pt) | 2004-02-11 | 2007-07-03 | Smithkline Beecham Corp | composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto |
| US7576212B2 (en) * | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| WO2006109876A1 (ja) | 2005-04-08 | 2006-10-19 | Eisai R & D Management Co., Ltd. | 不随意運動治療剤 |
| WO2007006591A2 (fr) | 2005-07-13 | 2007-01-18 | Bayer Cropscience Sa | Dihalogenation d'hydroxipyridones n,o-disubstituees et leurs utilisations |
| WO2007081901A2 (en) | 2006-01-05 | 2007-07-19 | The Scripps Research Institute | Pyrimidinone derivatives as protein kinase inhibitors |
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| US20100056526A1 (en) | 2006-11-24 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
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| AU2008276057B2 (en) | 2007-07-17 | 2013-01-31 | Bristol-Myers Squibb Company | Method for modulating GPR119 G protein-coupled receptor and selected compounds |
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| EP3469907B1 (en) * | 2010-12-06 | 2021-03-03 | Aclaris Therapeutics, Inc. | Substituted pyridinone-pyridinyl compounds |
| US9056110B2 (en) * | 2011-12-06 | 2015-06-16 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| ES2869048T3 (es) * | 2013-06-07 | 2021-10-22 | Aclaris Therapeutics Inc | Compuestos de piridinona-piridinilo sustituidos con metil/fluoro-piridinil-metoxi y compuestos de piridinona-piridinilo sustituidos con fluoro-pirimidinil-metoxi |
| USD789061S1 (en) * | 2015-11-04 | 2017-06-13 | Salomon S.A.S. | Upper of a footwear article |
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2014
- 2014-06-06 ES ES14808115T patent/ES2869048T3/es active Active
- 2014-06-06 DK DK14808115.1T patent/DK3003039T3/da active
- 2014-06-06 CN CN201480032278.5A patent/CN105263326B/zh active Active
- 2014-06-06 LT LTEP14808115.1T patent/LT3003039T/lt unknown
- 2014-06-06 KR KR1020217032643A patent/KR102470598B1/ko active IP Right Grant
- 2014-06-06 KR KR1020167000291A patent/KR102313515B1/ko active IP Right Grant
- 2014-06-06 SI SI201431823T patent/SI3003039T1/sl unknown
- 2014-06-06 EP EP14808115.1A patent/EP3003039B1/en active Active
- 2014-06-06 PT PT148081151T patent/PT3003039T/pt unknown
- 2014-06-06 PL PL14808115T patent/PL3003039T3/pl unknown
- 2014-06-06 EP EP21150054.1A patent/EP3845529A1/en active Pending
- 2014-06-06 CA CA2917344A patent/CA2917344C/en active Active
- 2014-06-06 RS RS20210426A patent/RS61724B1/sr unknown
- 2014-06-06 HU HUE14808115A patent/HUE054178T2/hu unknown
- 2014-06-06 KR KR1020227039952A patent/KR102653785B1/ko active IP Right Grant
- 2014-06-06 WO PCT/US2014/041381 patent/WO2014197846A1/en active Application Filing
- 2014-06-06 US US14/298,610 patent/US9115089B2/en active Active
- 2014-06-06 JP JP2016518047A patent/JP6699909B2/ja active Active
- 2014-06-06 CN CN201810282918.8A patent/CN108478579B/zh active Active
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2015
- 2015-08-07 US US14/821,396 patent/US9636333B2/en active Active
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2020
- 2020-01-15 JP JP2020004547A patent/JP6838796B2/ja active Active
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2021
- 2021-02-08 JP JP2021018583A patent/JP7146968B2/ja active Active
- 2021-03-31 CY CY20211100281T patent/CY1124222T1/el unknown
- 2021-05-20 HR HRP20210813TT patent/HRP20210813T1/hr unknown
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2022
- 2022-09-21 JP JP2022150254A patent/JP2022180524A/ja active Pending
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