DK3027598T3 - Oxoquinazolinyl-butanamidderivater - Google Patents
Oxoquinazolinyl-butanamidderivater Download PDFInfo
- Publication number
- DK3027598T3 DK3027598T3 DK14739045.4T DK14739045T DK3027598T3 DK 3027598 T3 DK3027598 T3 DK 3027598T3 DK 14739045 T DK14739045 T DK 14739045T DK 3027598 T3 DK3027598 T3 DK 3027598T3
- Authority
- DK
- Denmark
- Prior art keywords
- butanamidderivater
- quinazolinyl
- oxo
- quinazolinyl butanamidderivater
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13003815 | 2013-07-31 | ||
| PCT/EP2014/001895 WO2015014442A1 (en) | 2013-07-31 | 2014-07-10 | Oxoquinazolinyl-butanamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3027598T3 true DK3027598T3 (da) | 2017-05-22 |
Family
ID=48915813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14739045.4T DK3027598T3 (da) | 2013-07-31 | 2014-07-10 | Oxoquinazolinyl-butanamidderivater |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9901577B2 (da) |
| EP (1) | EP3027598B1 (da) |
| JP (1) | JP6423875B2 (da) |
| KR (1) | KR102331389B1 (da) |
| CN (1) | CN105392784B (da) |
| AR (1) | AR097087A1 (da) |
| AU (1) | AU2014298955B2 (da) |
| BR (1) | BR112016001645B1 (da) |
| CA (1) | CA2919905C (da) |
| DK (1) | DK3027598T3 (da) |
| ES (1) | ES2632988T3 (da) |
| HK (1) | HK1222391A1 (da) |
| HR (1) | HRP20171053T1 (da) |
| HU (1) | HUE032846T2 (da) |
| IL (1) | IL243734B (da) |
| LT (1) | LT3027598T (da) |
| MX (1) | MX359656B (da) |
| NZ (1) | NZ716593A (da) |
| PL (1) | PL3027598T3 (da) |
| PT (1) | PT3027598T (da) |
| RS (1) | RS56211B1 (da) |
| RU (1) | RU2669393C2 (da) |
| SG (1) | SG11201600743WA (da) |
| SI (1) | SI3027598T1 (da) |
| WO (1) | WO2015014442A1 (da) |
| ZA (1) | ZA201601333B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2948067A1 (en) * | 2014-05-07 | 2015-11-12 | Merck Patent Gmbh | Heterocyclyl-butanamide derivatives |
| MX2018005515A (es) * | 2015-11-02 | 2018-08-01 | Merck Patent Gmbh | Derivados de 1,4-dicarbonil-piperidilo. |
| US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| GB201615282D0 (en) * | 2016-09-08 | 2016-10-26 | Univ Bath | Tankyrase inhibitors |
| CA3047137A1 (en) | 2016-12-30 | 2018-07-05 | Mitobridge, Inc. | Poly-adp ribose polymerase (parp) inhibitors |
| WO2019126443A1 (en) | 2017-12-21 | 2019-06-27 | Ribon Therapeutics Inc. | Quinazolinones as parp14 inhibitors |
| CN109180702B (zh) * | 2018-10-29 | 2021-11-30 | 四川大学 | 一种噻吩并嘧啶酮化合物及其用途 |
| AU2019392502A1 (en) | 2018-12-03 | 2021-07-22 | Merck Patent Gmbh | 4-heteroarylcarbonyl-N-(phenyl or heteroaryl) piperidine-1-carboxamides as inhibitors of tankyrases |
| WO2023161881A1 (en) * | 2022-02-25 | 2023-08-31 | Glaxosmithkline Intellectual Property Development Limited | Cytotoxicity targeting chimeras for ccr2-expressing cells |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| JP2004513070A (ja) * | 2000-05-26 | 2004-04-30 | イデニクス（ケイマン）リミテツド | β−Ｌ−２’−デオキシヌクレオシドを用いたデルタ型肝炎ウイルス感染の処置方法 |
| AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
| US20040176361A1 (en) * | 2001-05-23 | 2004-09-09 | Masakazu Fujio | Fused heterocyclic compound and medicinal use thereof |
| BRPI0408284B8 (pt) * | 2003-03-12 | 2021-05-25 | Kudos Pharm Ltd | compostos derivados de ftalazinona, seu uso e composição farmacêutica compreendendo os mesmos |
| EP1763518B1 (en) * | 2004-06-30 | 2012-01-11 | Janssen Pharmaceutica NV | Substituted 2-alkyl quinazolinone derivatives as parp inhibitors |
| UY31603A1 (es) * | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
| CN101492425A (zh) * | 2009-02-27 | 2009-07-29 | 无锡市凯奥善生物医药科技有限公司 | 一类parp抑制剂的化合物 |
| EP2731942B1 (en) * | 2011-07-13 | 2015-09-23 | Novartis AG | Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors |
| WO2014036022A1 (en) * | 2012-08-29 | 2014-03-06 | Amgen Inc. | Quinazolinone compounds and derivatives thereof |
-
2014
- 2014-07-10 SG SG11201600743WA patent/SG11201600743WA/en unknown
- 2014-07-10 ES ES14739045.4T patent/ES2632988T3/es active Active
- 2014-07-10 SI SI201430283T patent/SI3027598T1/sl unknown
- 2014-07-10 EP EP14739045.4A patent/EP3027598B1/en active Active
- 2014-07-10 PL PL14739045T patent/PL3027598T3/pl unknown
- 2014-07-10 CN CN201480042153.0A patent/CN105392784B/zh active Active
- 2014-07-10 LT LTEP14739045.4T patent/LT3027598T/lt unknown
- 2014-07-10 NZ NZ716593A patent/NZ716593A/en not_active IP Right Cessation
- 2014-07-10 CA CA2919905A patent/CA2919905C/en active Active
- 2014-07-10 RS RS20170679A patent/RS56211B1/sr unknown
- 2014-07-10 BR BR112016001645-9A patent/BR112016001645B1/pt active IP Right Grant
- 2014-07-10 JP JP2016530371A patent/JP6423875B2/ja active Active
- 2014-07-10 MX MX2016001136A patent/MX359656B/es active IP Right Grant
- 2014-07-10 HU HUE14739045A patent/HUE032846T2/en unknown
- 2014-07-10 AU AU2014298955A patent/AU2014298955B2/en not_active Ceased
- 2014-07-10 RU RU2016106952A patent/RU2669393C2/ru active
- 2014-07-10 US US14/909,365 patent/US9901577B2/en active Active
- 2014-07-10 WO PCT/EP2014/001895 patent/WO2015014442A1/en active Application Filing
- 2014-07-10 PT PT147390454T patent/PT3027598T/pt unknown
- 2014-07-10 KR KR1020167005040A patent/KR102331389B1/ko active IP Right Grant
- 2014-07-10 DK DK14739045.4T patent/DK3027598T3/da active
- 2014-07-28 AR ARP140102799A patent/AR097087A1/es active IP Right Grant
-
2016
- 2016-01-21 IL IL243734A patent/IL243734B/en active IP Right Grant
- 2016-02-26 ZA ZA2016/01333A patent/ZA201601333B/en unknown
- 2016-09-06 HK HK16110560.1A patent/HK1222391A1/zh not_active IP Right Cessation
-
2017
- 2017-07-10 HR HRP20171053TT patent/HRP20171053T1/hr unknown
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