DK3077047T3 - Aramcholsalte - Google Patents
Aramcholsalte Download PDFInfo
- Publication number
- DK3077047T3 DK3077047T3 DK14868582.9T DK14868582T DK3077047T3 DK 3077047 T3 DK3077047 T3 DK 3077047T3 DK 14868582 T DK14868582 T DK 14868582T DK 3077047 T3 DK3077047 T3 DK 3077047T3
- Authority
- DK
- Denmark
- Prior art keywords
- aramcholsalte
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/05—Mono-, di- or tri-ethylamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911478P | 2013-12-04 | 2013-12-04 | |
| PCT/IL2014/051052 WO2015083164A1 (en) | 2013-12-04 | 2014-12-04 | Aramchol salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3077047T3 true DK3077047T3 (da) | 2019-07-15 |
Family
ID=53272986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14868582.9T DK3077047T3 (da) | 2013-12-04 | 2014-12-04 | Aramcholsalte |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20160304553A1 (da) |
| EP (1) | EP3077047B1 (da) |
| JP (2) | JP6675310B2 (da) |
| KR (1) | KR102320191B1 (da) |
| CN (2) | CN110437298A (da) |
| AU (2) | AU2014358668B2 (da) |
| BR (1) | BR112016012465B1 (da) |
| CA (1) | CA2930232C (da) |
| CY (1) | CY1121736T1 (da) |
| DK (1) | DK3077047T3 (da) |
| ES (1) | ES2732845T3 (da) |
| HK (1) | HK1226347A1 (da) |
| HR (1) | HRP20191023T1 (da) |
| HU (1) | HUE045209T2 (da) |
| LT (1) | LT3077047T (da) |
| PL (1) | PL3077047T3 (da) |
| PT (1) | PT3077047T (da) |
| RS (1) | RS59067B1 (da) |
| SI (1) | SI3077047T1 (da) |
| TR (1) | TR201909447T4 (da) |
| WO (1) | WO2015083164A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL227890A0 (en) * | 2013-08-08 | 2014-01-30 | Galderm Therapeutics Ltd | Antiaging compounds containing bile acid and fatty acid conjugates |
| CN110437298A (zh) * | 2013-12-04 | 2019-11-12 | 盖尔梅德研究与发展有限公司 | Aramchol盐 |
| US10849911B2 (en) | 2015-06-10 | 2020-12-01 | Galmed Research And Development Ltd. | Low dose compositions of Aramachol salts |
| JP6812405B2 (ja) * | 2015-07-12 | 2021-01-13 | ツェーエフエスオー・ゲーエムベーハー | コレカルシフェロール硫酸塩及びビタミンｄ欠乏症の処置のためのこれらの使用 |
| WO2017017677A1 (en) * | 2015-07-27 | 2017-02-02 | Galmed Research And Development Ltd. | Combination treatment for liver disease |
| IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
| FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| CN109862888B (zh) * | 2016-09-28 | 2022-08-12 | 艾格尔峰生物制药有限公司 | 用于治疗非酒精性脂肪性肝炎的方法和药物组合物 |
| CN110062634A (zh) * | 2016-11-10 | 2019-07-26 | 盖尔梅德研究与发展有限公司 | 非酒精性脂肪肝病患者中纤维化的抑制 |
| US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
| EP3636655A4 (en) | 2017-06-07 | 2020-08-26 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | CRYSTALLINE FORM OF A FATTY ACID - BILIARY ACID CONJUGATE, PROCESS OF PREPARATION AND APPLICATION |
| WO2019125913A1 (en) * | 2017-12-20 | 2019-06-27 | Michael Guarnieri | Nutritional bolus for animals |
| JP6612004B1 (ja) * | 2018-07-31 | 2019-11-27 | 株式会社親広産業 | グルコース消費促進剤および解糖系促進剤 |
| WO2020026471A1 (ja) * | 2018-07-31 | 2020-02-06 | 株式会社親広産業 | グルコース消費促進剤および解糖系促進剤 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2252863A (en) * | 1941-02-03 | 1941-08-19 | Searle & Co | Quaternary ammonium salts |
| GB1532413A (en) * | 1974-12-23 | 1978-11-15 | Union International Co Ltd | Chenodeoxycholic acid |
| IL142650A (en) * | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
| IL123998A (en) * | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
| US8975246B2 (en) * | 2001-04-17 | 2015-03-10 | Galmed Research And Development Ltd. | Bile acid or bile salt fatty acid conjugates |
| ITMI20061735A1 (it) * | 2006-09-12 | 2008-03-13 | Dipharma Spa | Procedimento per la preparazione di acidi colanici |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2010086864A1 (en) * | 2009-02-02 | 2010-08-05 | Galmed International Ltd. | Methods and compositions for treating alzheimer's disease |
| CN102115486B (zh) * | 2009-12-30 | 2015-06-03 | 上海特化医药科技有限公司 | 一种3-β-花生酰胺基-7α,12α,5β-胆烷-24-羧酸的制备方法 |
| AU2011209754A1 (en) * | 2010-01-28 | 2012-07-26 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions for the treatment of pain and other indicatons |
| CA2787360C (en) * | 2010-02-03 | 2019-03-05 | Takeda Pharmaceutical Company Limited | Pyrrol0[3,2-c]pyridinyl-4-benzamide compounds and their use as apoptosis signal-regulating kinase 1 inhibitors |
| RS57377B1 (sr) * | 2010-12-07 | 2018-08-31 | Amira Pharmaceuticals Inc | Policiklični lpa1 antagonist i njegove primene |
| CN110437298A (zh) * | 2013-12-04 | 2019-11-12 | 盖尔梅德研究与发展有限公司 | Aramchol盐 |
-
2014
- 2014-12-04 CN CN201910687060.8A patent/CN110437298A/zh active Pending
- 2014-12-04 BR BR112016012465-0A patent/BR112016012465B1/pt active IP Right Grant
- 2014-12-04 JP JP2016535210A patent/JP6675310B2/ja active Active
- 2014-12-04 TR TR2019/09447T patent/TR201909447T4/tr unknown
- 2014-12-04 EP EP14868582.9A patent/EP3077047B1/en active Active
- 2014-12-04 DK DK14868582.9T patent/DK3077047T3/da active
- 2014-12-04 RS RS20190787A patent/RS59067B1/sr unknown
- 2014-12-04 US US15/100,993 patent/US20160304553A1/en not_active Abandoned
- 2014-12-04 ES ES14868582T patent/ES2732845T3/es active Active
- 2014-12-04 PT PT14868582T patent/PT3077047T/pt unknown
- 2014-12-04 AU AU2014358668A patent/AU2014358668B2/en active Active
- 2014-12-04 HU HUE14868582A patent/HUE045209T2/hu unknown
- 2014-12-04 SI SI201431253T patent/SI3077047T1/sl unknown
- 2014-12-04 WO PCT/IL2014/051052 patent/WO2015083164A1/en active Application Filing
- 2014-12-04 LT LTEP14868582.9T patent/LT3077047T/lt unknown
- 2014-12-04 KR KR1020167017460A patent/KR102320191B1/ko active IP Right Grant
- 2014-12-04 CA CA2930232A patent/CA2930232C/en active Active
- 2014-12-04 PL PL14868582T patent/PL3077047T3/pl unknown
- 2014-12-04 CN CN201480064913.8A patent/CN105848718B/zh active Active
-
2016
- 2016-12-22 HK HK16114629A patent/HK1226347A1/zh unknown
-
2019
- 2019-06-06 HR HRP20191023TT patent/HRP20191023T1/hr unknown
- 2019-07-01 CY CY20191100688T patent/CY1121736T1/el unknown
- 2019-12-06 AU AU2019275638A patent/AU2019275638B2/en active Active
-
2020
- 2020-03-10 JP JP2020040825A patent/JP2020111584A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN110437298A (zh) | 2019-11-12 |
| JP6675310B2 (ja) | 2020-04-01 |
| CN105848718A (zh) | 2016-08-10 |
| HRP20191023T1 (hr) | 2019-09-06 |
| BR112016012465A8 (pt) | 2020-05-05 |
| CY1121736T1 (el) | 2020-07-31 |
| AU2019275638A1 (en) | 2020-01-23 |
| AU2019275638B2 (en) | 2021-05-06 |
| CA2930232A1 (en) | 2015-06-11 |
| RS59067B1 (sr) | 2019-09-30 |
| KR20160093051A (ko) | 2016-08-05 |
| US20160304553A1 (en) | 2016-10-20 |
| KR102320191B1 (ko) | 2021-11-03 |
| JP2016539131A (ja) | 2016-12-15 |
| WO2015083164A1 (en) | 2015-06-11 |
| LT3077047T (lt) | 2019-08-26 |
| BR112016012465B1 (pt) | 2023-04-18 |
| CN105848718B (zh) | 2019-07-30 |
| ES2732845T3 (es) | 2019-11-26 |
| AU2014358668B2 (en) | 2019-10-24 |
| EP3077047A1 (en) | 2016-10-12 |
| SI3077047T1 (sl) | 2019-09-30 |
| EP3077047A4 (en) | 2017-05-03 |
| EP3077047B1 (en) | 2019-04-24 |
| HK1226347A1 (zh) | 2017-09-29 |
| JP2020111584A (ja) | 2020-07-27 |
| HUE045209T2 (hu) | 2019-12-30 |
| AU2014358668A1 (en) | 2016-06-02 |
| TR201909447T4 (tr) | 2019-07-22 |
| CA2930232C (en) | 2020-09-15 |
| PL3077047T3 (pl) | 2019-10-31 |
| PT3077047T (pt) | 2019-07-11 |
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