MX359656B - Derivados de oxoquinazolinil-butanamida. - Google Patents

Derivados de oxoquinazolinil-butanamida.

Info

Publication number
MX359656B
MX359656B MX2016001136A MX2016001136A MX359656B MX 359656 B MX359656 B MX 359656B MX 2016001136 A MX2016001136 A MX 2016001136A MX 2016001136 A MX2016001136 A MX 2016001136A MX 359656 B MX359656 B MX 359656B
Authority
MX
Mexico
Prior art keywords
oxoquinazolinyl
butanamide derivatives
diseases
butanamide
derivatives
Prior art date
Application number
MX2016001136A
Other languages
English (en)
Other versions
MX2016001136A (es
Inventor
Dorsch Dieter
Buchstaller Hans-Peter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2016001136A publication Critical patent/MX2016001136A/es
Publication of MX359656B publication Critical patent/MX359656B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Los compuestos de la fórmula I (ver Fórmula) en donde R1-R3 y Z tienen los significados indicados en la reivindicación 1, son inhibidores de Tankirasa y se pueden emplear, inter alia, para el tratamiento de enfermedades tales como cáncer, enfermedades cardiovasculares, lesión del sistema nervioso central y diferentes formas de inflamación.
MX2016001136A 2013-07-31 2014-07-10 Derivados de oxoquinazolinil-butanamida. MX359656B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13003815 2013-07-31
PCT/EP2014/001895 WO2015014442A1 (en) 2013-07-31 2014-07-10 Oxoquinazolinyl-butanamide derivatives

Publications (2)

Publication Number Publication Date
MX2016001136A MX2016001136A (es) 2016-04-29
MX359656B true MX359656B (es) 2018-10-05

Family

ID=48915813

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016001136A MX359656B (es) 2013-07-31 2014-07-10 Derivados de oxoquinazolinil-butanamida.

Country Status (26)

Country Link
US (1) US9901577B2 (es)
EP (1) EP3027598B1 (es)
JP (1) JP6423875B2 (es)
KR (1) KR102331389B1 (es)
CN (1) CN105392784B (es)
AR (1) AR097087A1 (es)
AU (1) AU2014298955B2 (es)
BR (1) BR112016001645B1 (es)
CA (1) CA2919905C (es)
DK (1) DK3027598T3 (es)
ES (1) ES2632988T3 (es)
HK (1) HK1222391A1 (es)
HR (1) HRP20171053T1 (es)
HU (1) HUE032846T2 (es)
IL (1) IL243734B (es)
LT (1) LT3027598T (es)
MX (1) MX359656B (es)
NZ (1) NZ716593A (es)
PL (1) PL3027598T3 (es)
PT (1) PT3027598T (es)
RS (1) RS56211B1 (es)
RU (1) RU2669393C2 (es)
SG (1) SG11201600743WA (es)
SI (1) SI3027598T1 (es)
WO (1) WO2015014442A1 (es)
ZA (1) ZA201601333B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2016147727A (ru) * 2014-05-07 2018-06-08 Мерк Патент Гмбх Гетероциклилбутанамидные производные
RU2018119935A (ru) * 2015-11-02 2019-12-04 Мерк Патент Гмбх 1,4-дикарбонилпиперидильные производные
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
WO2018125961A1 (en) 2016-12-30 2018-07-05 Mitobridge, Inc. Poly-adp ribose polymerase (parp) inhibitors
DK3728207T3 (da) 2017-12-21 2023-03-13 Ribon Therapeutics Inc Quinazolinoner som parp14-inhibitorer
CN109180702B (zh) * 2018-10-29 2021-11-30 四川大学 一种噻吩并嘧啶酮化合物及其用途
EP3891136B1 (en) 2018-12-03 2023-07-19 Merck Patent GmbH 4-heteroarylcarbonyl-n-(phenyl or heteroaryl)piperidine-1-carboxamides as inhibitors of tankyrases
WO2023161881A1 (en) * 2022-02-25 2023-08-31 Glaxosmithkline Intellectual Property Development Limited Cytotoxicity targeting chimeras for ccr2-expressing cells

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202915D0 (en) * 1992-02-12 1992-03-25 Wellcome Found Chemical compounds
CA2410488C (en) * 2000-05-26 2009-10-27 Idenix (Cayman) Limited Methods of treating hepatitis delta virus infection with .beta.-l-2' deoxy-nucleosides
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
US20040176361A1 (en) * 2001-05-23 2004-09-09 Masakazu Fujio Fused heterocyclic compound and medicinal use thereof
NZ542680A (en) * 2003-03-12 2008-08-29 Kudos Pharm Ltd Phthalazinone derivatives
EA012416B1 (ru) * 2004-06-30 2009-10-30 Янссен Фармацевтика Н.В. Производные замещенного 2-алкилхиназолинона как ингибиторы parp
UY31603A1 (es) * 2008-01-23 2009-08-31 Derivados de ftalazinona
CN101492425A (zh) * 2009-02-27 2009-07-29 无锡市凯奥善生物医药科技有限公司 一类parp抑制剂的化合物
JP2014520858A (ja) * 2011-07-13 2014-08-25 ノバルティス アーゲー タンキラーゼ阻害剤として用いるための新規な２−ピペリジン−１−イル−アセトアミド化合物
EP2890696A1 (en) * 2012-08-29 2015-07-08 Amgen, Inc. Quinazolinone compounds and derivatives thereof

Also Published As

Publication number Publication date
US9901577B2 (en) 2018-02-27
SI3027598T1 (sl) 2017-08-31
DK3027598T3 (da) 2017-05-22
BR112016001645B1 (pt) 2023-04-11
AU2014298955A1 (en) 2016-03-10
EP3027598B1 (en) 2017-04-12
US20160184310A1 (en) 2016-06-30
ES2632988T3 (es) 2017-09-18
BR112016001645A8 (pt) 2020-01-21
CA2919905A1 (en) 2015-02-05
HRP20171053T1 (hr) 2017-10-06
MX2016001136A (es) 2016-04-29
RS56211B1 (sr) 2017-11-30
PL3027598T3 (pl) 2017-09-29
PT3027598T (pt) 2017-07-17
HK1222391A1 (zh) 2017-06-30
CN105392784B (zh) 2018-10-09
HUE032846T2 (en) 2017-11-28
RU2016106952A3 (es) 2018-05-14
EP3027598A1 (en) 2016-06-08
KR20160037985A (ko) 2016-04-06
JP2016525556A (ja) 2016-08-25
CN105392784A (zh) 2016-03-09
AU2014298955B2 (en) 2018-03-01
NZ716593A (en) 2021-07-30
IL243734A0 (en) 2016-04-21
CA2919905C (en) 2021-08-10
LT3027598T (lt) 2017-06-12
ZA201601333B (en) 2019-12-18
AR097087A1 (es) 2016-02-17
JP6423875B2 (ja) 2018-11-14
RU2016106952A (ru) 2017-09-04
WO2015014442A1 (en) 2015-02-05
KR102331389B1 (ko) 2021-11-26
RU2669393C2 (ru) 2018-10-11
BR112016001645A2 (pt) 2017-08-01
IL243734B (en) 2019-09-26
SG11201600743WA (en) 2016-02-26

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