PL3003039T3 - Związki pirydynonopirydynylowe podstawione metylo/fluoropirydynylometoksylem oraz związki pirydynonopirydynylowe podstawione fluoropirymidynylometoksylem - Google Patents

Związki pirydynonopirydynylowe podstawione metylo/fluoropirydynylometoksylem oraz związki pirydynonopirydynylowe podstawione fluoropirymidynylometoksylem

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Publication number
PL3003039T3
PL3003039T3 PL14808115T PL14808115T PL3003039T3 PL 3003039 T3 PL3003039 T3 PL 3003039T3 PL 14808115 T PL14808115 T PL 14808115T PL 14808115 T PL14808115 T PL 14808115T PL 3003039 T3 PL3003039 T3 PL 3003039T3
Authority
PL
Poland
Prior art keywords
pyridinyl
fluoro
methoxy substituted
compounds
substituted pyridinone
Prior art date
Application number
PL14808115T
Other languages
English (en)
Inventor
Susan L. Hockerman
Joseph B. Monahan
Shaun R. Selness
Original Assignee
Aclaris Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclaris Therapeutics, Inc. filed Critical Aclaris Therapeutics, Inc.
Publication of PL3003039T3 publication Critical patent/PL3003039T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
PL14808115T 2013-06-07 2014-06-06 Związki pirydynonopirydynylowe podstawione metylo/fluoropirydynylometoksylem oraz związki pirydynonopirydynylowe podstawione fluoropirymidynylometoksylem PL3003039T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361832736P 2013-06-07 2013-06-07
EP14808115.1A EP3003039B1 (en) 2013-06-07 2014-06-06 Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
PCT/US2014/041381 WO2014197846A1 (en) 2013-06-07 2014-06-06 Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds

Publications (1)

Publication Number Publication Date
PL3003039T3 true PL3003039T3 (pl) 2021-10-25

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PL14808115T PL3003039T3 (pl) 2013-06-07 2014-06-06 Związki pirydynonopirydynylowe podstawione metylo/fluoropirydynylometoksylem oraz związki pirydynonopirydynylowe podstawione fluoropirymidynylometoksylem

Country Status (18)

Country Link
US (2) US9115089B2 (pl)
EP (2) EP3003039B1 (pl)
JP (4) JP6699909B2 (pl)
KR (3) KR102653785B1 (pl)
CN (2) CN108478579B (pl)
CA (1) CA2917344C (pl)
CY (1) CY1124222T1 (pl)
DK (1) DK3003039T3 (pl)
ES (1) ES2869048T3 (pl)
HR (1) HRP20210813T1 (pl)
HU (1) HUE054178T2 (pl)
LT (1) LT3003039T (pl)
PL (1) PL3003039T3 (pl)
PT (1) PT3003039T (pl)
RS (1) RS61724B1 (pl)
SI (1) SI3003039T1 (pl)
SM (1) SMT202100117T1 (pl)
WO (1) WO2014197846A1 (pl)

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KR20230112696A (ko) * 2020-11-23 2023-07-27 어클라리스 쎄라퓨틱스, 인코포레이티드 치환된 피리디논-피리디닐 화합물의 합성 방법
CN116685322A (zh) * 2020-11-23 2023-09-01 阿克拉瑞斯治疗股份有限公司 合成被取代的吡啶酮-吡啶基化合物的方法
EP4313970A4 (en) * 2021-03-31 2025-06-25 Xinthera, Inc. MK2 INHIBITORS AND THEIR USES
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WO2023001282A1 (zh) * 2021-07-23 2023-01-26 南京明德新药研发有限公司 杂环取代的嘧啶衍生物
TW202315625A (zh) * 2021-08-13 2023-04-16 大陸商深圳信立泰藥業股份有限公司 三聯吡啶二酮化合物或其鹽、包括其藥物組合物及其用途
CN116178345B (zh) * 2021-10-19 2024-08-13 深圳信立泰药业股份有限公司 一种取代的嘧啶基-吡啶基-吡啶酮化合物及其制备方法与应用
TWI866007B (zh) * 2021-12-29 2024-12-11 大陸商上海美悦生物科技發展有限公司 p38 MAPK/MK2通路調節劑及其組合物、製備方法和用途
TWI836822B (zh) * 2021-12-29 2024-03-21 大陸商上海美悦生物科技發展有限公司 p38 MAPK/MK2通路調節劑及其組合物、製備方法和用途
CN116396274B (zh) * 2022-01-06 2025-11-11 深圳信立泰药业股份有限公司 一种取代的联吡啶酮类化合物及其制备方法与应用
CN116425722B (zh) * 2022-01-13 2025-11-11 深圳信立泰药业股份有限公司 一种取代的联吡啶酮-芳(杂)环类化合物及其制备方法与应用
WO2023134765A1 (zh) * 2022-01-14 2023-07-20 上海翰森生物医药科技有限公司 含五元环类衍生物、其制备方法和应用
KR20240134978A (ko) 2022-01-14 2024-09-10 상하이 한서 바이오메디컬 컴퍼니 리미티드 피리딘 함유 폴리시클릭 유도체, 이의 제조 방법 및 용도
WO2023150709A2 (en) * 2022-02-04 2023-08-10 Aclaris Therapeutics, Inc. Methods of synthesizing deuterated substituted pyridinone-pyridinyl compounds
CN119384410A (zh) * 2022-03-03 2025-01-28 深圳信立泰药业股份有限公司 一种氘代三联吡啶二酮化合物或其盐及其制备方法与应用
CN115057811B (zh) * 2022-05-26 2024-06-14 安庆朗坤药业有限公司 一种2-溴甲基-3,5-二氟吡啶的制备方法
WO2024022412A1 (zh) * 2022-07-28 2024-02-01 深圳信立泰药业股份有限公司 一种式(i)所示的三联吡啶二酮化合物晶型及其制备方法与应用
CN119053588A (zh) * 2022-08-30 2024-11-29 长春金赛药业有限责任公司 p38α-MK2抑制剂化合物、药物组合物及其应用
TW202430516A (zh) * 2022-10-05 2024-08-01 美商辛瑟拉股份有限公司 Ｍｋ２抑制劑之晶形
TW202428271A (zh) * 2022-11-16 2024-07-16 大陸商上海美悦生物科技發展有限公司 吡啶氮氧化物類衍生物及其藥物組合物、製備方法和用途
WO2024149359A1 (zh) * 2023-01-13 2024-07-18 上海美悦生物科技发展有限公司 苯基取代的杂芳基类化合物及其药物组合物、制备方法和用途
WO2025002076A1 (zh) * 2023-06-26 2025-01-02 深圳信立泰药业股份有限公司 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用
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