EA201790613A1 - Триазольные соединения в качестве блокаторов кальциевых каналов т-типа - Google Patents
Триазольные соединения в качестве блокаторов кальциевых каналов т-типаInfo
- Publication number
- EA201790613A1 EA201790613A1 EA201790613A EA201790613A EA201790613A1 EA 201790613 A1 EA201790613 A1 EA 201790613A1 EA 201790613 A EA201790613 A EA 201790613A EA 201790613 A EA201790613 A EA 201790613A EA 201790613 A1 EA201790613 A1 EA 201790613A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- calcium channel
- type calcium
- triazole compounds
- channel blocks
- compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к соединениям формулы (I)где X, Y, R, R, (R)и (R)являются такими, как определено в описании, и к фармацевтически приемлемым солям таких соединений. Эти соединения являются полезными в качестве блокаторов кальциевых каналов Т-типа.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2014069592 | 2014-09-15 | ||
PCT/EP2015/070934 WO2016041892A1 (en) | 2014-09-15 | 2015-09-14 | Triazole compounds as t-type calcium channel blockers |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201790613A1 true EA201790613A1 (ru) | 2017-12-29 |
EA201790613A8 EA201790613A8 (ru) | 2018-10-31 |
EA032873B1 EA032873B1 (ru) | 2019-07-31 |
Family
ID=54106361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790613A EA032873B1 (ru) | 2014-09-15 | 2015-09-14 | Триазольные соединения в качестве блокаторов кальциевых каналов т-типа |
Country Status (16)
Country | Link |
---|---|
US (1) | US10246426B2 (ru) |
EP (1) | EP3194374B1 (ru) |
JP (1) | JP6500092B2 (ru) |
KR (1) | KR102424750B1 (ru) |
CN (1) | CN107074822B (ru) |
AU (1) | AU2015317022B2 (ru) |
CA (1) | CA2956816C (ru) |
CL (1) | CL2017000616A1 (ru) |
EA (1) | EA032873B1 (ru) |
ES (1) | ES2693052T3 (ru) |
IL (1) | IL251042A0 (ru) |
MX (1) | MX367519B (ru) |
PH (1) | PH12017500447A1 (ru) |
PL (1) | PL3194374T3 (ru) |
SG (1) | SG11201701998XA (ru) |
WO (1) | WO2016041892A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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PT3152199T (pt) | 2014-06-03 | 2018-11-26 | Idorsia Pharmaceuticals Ltd | Compostos de pirazol e a sua utilização como bloqueadores de canais de cálcio do tipo t |
EP3554490B1 (en) | 2016-12-16 | 2022-02-16 | Idorsia Pharmaceuticals Ltd | Pharmaceutical combination comprising a t-type calcium channel blocker |
JP6972144B2 (ja) | 2017-02-06 | 2021-11-24 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | 1−アリール−1−トリフルオロメチルシクロプロパンを合成するための新規な方法 |
CN110831932A (zh) | 2017-07-05 | 2020-02-21 | 爱杜西亚药品有限公司 | 晶体形式的n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-环丙基)-苯基]-乙酰胺 |
JP2022540253A (ja) | 2019-07-11 | 2022-09-14 | プラクシス プレシジョン メディシンズ, インコーポレイテッド | T型カルシウムチャネル調節因子の製剤およびその使用方法 |
WO2023240205A1 (en) | 2022-06-10 | 2023-12-14 | Neurocrine Biosciences, Inc. | Deuterated compounds |
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PT3152199T (pt) | 2014-06-03 | 2018-11-26 | Idorsia Pharmaceuticals Ltd | Compostos de pirazol e a sua utilização como bloqueadores de canais de cálcio do tipo t |
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2015
- 2015-09-14 CA CA2956816A patent/CA2956816C/en active Active
- 2015-09-14 WO PCT/EP2015/070934 patent/WO2016041892A1/en active Application Filing
- 2015-09-14 PL PL15763321T patent/PL3194374T3/pl unknown
- 2015-09-14 US US15/510,980 patent/US10246426B2/en active Active
- 2015-09-14 ES ES15763321T patent/ES2693052T3/es active Active
- 2015-09-14 CN CN201580049589.7A patent/CN107074822B/zh active Active
- 2015-09-14 EP EP15763321.5A patent/EP3194374B1/en active Active
- 2015-09-14 JP JP2017514443A patent/JP6500092B2/ja active Active
- 2015-09-14 AU AU2015317022A patent/AU2015317022B2/en active Active
- 2015-09-14 KR KR1020177010036A patent/KR102424750B1/ko active IP Right Grant
- 2015-09-14 EA EA201790613A patent/EA032873B1/ru not_active IP Right Cessation
- 2015-09-14 SG SG11201701998XA patent/SG11201701998XA/en unknown
- 2015-09-14 MX MX2017003362A patent/MX367519B/es active IP Right Grant
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2017
- 2017-03-09 PH PH12017500447A patent/PH12017500447A1/en unknown
- 2017-03-09 IL IL251042A patent/IL251042A0/en unknown
- 2017-03-14 CL CL2017000616A patent/CL2017000616A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EA032873B1 (ru) | 2019-07-31 |
CL2017000616A1 (es) | 2017-11-24 |
AU2015317022B2 (en) | 2020-01-16 |
EA201790613A8 (ru) | 2018-10-31 |
PH12017500447A1 (en) | 2017-07-31 |
SG11201701998XA (en) | 2017-04-27 |
MX367519B (es) | 2019-08-26 |
KR20170052686A (ko) | 2017-05-12 |
JP2017532309A (ja) | 2017-11-02 |
WO2016041892A1 (en) | 2016-03-24 |
EP3194374A1 (en) | 2017-07-26 |
IL251042A0 (en) | 2017-04-30 |
JP6500092B2 (ja) | 2019-04-10 |
CA2956816C (en) | 2023-02-14 |
MX2017003362A (es) | 2017-06-28 |
US10246426B2 (en) | 2019-04-02 |
PL3194374T3 (pl) | 2019-01-31 |
BR112017005179A2 (pt) | 2017-12-05 |
CN107074822B (zh) | 2020-01-03 |
CA2956816A1 (en) | 2016-03-24 |
CN107074822A (zh) | 2017-08-18 |
US20180230109A1 (en) | 2018-08-16 |
KR102424750B1 (ko) | 2022-07-22 |
ES2693052T3 (es) | 2018-12-07 |
AU2015317022A1 (en) | 2017-04-27 |
BR112017005179A8 (pt) | 2017-12-26 |
EP3194374B1 (en) | 2018-08-01 |
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