EA202190346A1 - Способ и промежуточные продукты получения биластина - Google Patents

Способ и промежуточные продукты получения биластина

Info

Publication number
EA202190346A1
EA202190346A1 EA202190346A EA202190346A EA202190346A1 EA 202190346 A1 EA202190346 A1 EA 202190346A1 EA 202190346 A EA202190346 A EA 202190346A EA 202190346 A EA202190346 A EA 202190346A EA 202190346 A1 EA202190346 A1 EA 202190346A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bilastine
obtaining
intermediate products
formula
iii
Prior art date
Application number
EA202190346A
Other languages
English (en)
Inventor
Гонсало Эрнандес Эрреро
Нефтали Гарсия Домингес
Пабло Моран Поладура
Таня Гонсалес Гарсиа
Альваро Ганса Гонсалес
Палома Тато Сердейрас
Original Assignee
Фаэс Фарма, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фаэс Фарма, С.А. filed Critical Фаэс Фарма, С.А.
Publication of EA202190346A1 publication Critical patent/EA202190346A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение касается способа получения соединения формулы (III)где X обозначает уходящую группу; и R1 обозначает C1-C6-алкил; который включает окислительную перегруппировку соединения формулы (II) или его сольватаСоединения формулы (III) являются ключевыми промежуточными продуктами в синтезе биластина.
EA202190346A 2018-07-24 2019-07-23 Способ и промежуточные продукты получения биластина EA202190346A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382556.1A EP3599235A1 (en) 2018-07-24 2018-07-24 Process and intermediates for the preparation of bilastine
PCT/EP2019/069772 WO2020020873A1 (en) 2018-07-24 2019-07-23 Process and intermediates for the preparation of bilastine

Publications (1)

Publication Number Publication Date
EA202190346A1 true EA202190346A1 (ru) 2021-05-20

Family

ID=63103892

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202190346A EA202190346A1 (ru) 2018-07-24 2019-07-23 Способ и промежуточные продукты получения биластина

Country Status (27)

Country Link
US (1) US11370742B2 (ru)
EP (2) EP3599235A1 (ru)
JP (1) JP7145312B2 (ru)
KR (1) KR20210038905A (ru)
CN (1) CN112469709A (ru)
AU (1) AU2019311251B2 (ru)
BR (1) BR112021001179A2 (ru)
CA (1) CA3107879A1 (ru)
CL (1) CL2021000171A1 (ru)
CO (1) CO2021000940A2 (ru)
CY (1) CY1124909T1 (ru)
EA (1) EA202190346A1 (ru)
EC (1) ECSP21008461A (ru)
ES (1) ES2901786T3 (ru)
HR (1) HRP20211994T1 (ru)
HU (1) HUE056822T2 (ru)
LT (1) LT3826997T (ru)
MA (1) MA53370B1 (ru)
MX (1) MX2021000924A (ru)
PE (1) PE20211243A1 (ru)
PH (1) PH12021550144A1 (ru)
PL (1) PL3826997T3 (ru)
PT (1) PT3826997T (ru)
SG (1) SG11202100576WA (ru)
SI (1) SI3826997T1 (ru)
WO (1) WO2020020873A1 (ru)
ZA (1) ZA202101214B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022214921A1 (en) * 2021-04-10 2022-10-13 Ocimum Labs Private Limited An improved process for the preparation of intermediates used in the preparation of antihistamine agent
WO2023037184A2 (en) * 2021-08-19 2023-03-16 Biophore India Pharmaceuticals Pvt. Ltd Novel process for the preparation of bilastine and intermediates thereof
CN117024313A (zh) * 2023-08-09 2023-11-10 重庆恩联生物科技有限公司 一种比拉斯汀中间体2-甲基-2-{4-[2-甲基-4-磺酰氧基-乙基]苯基}丙酸甲酯的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108943A (en) * 1976-03-10 1977-09-12 Teikoku Hormone Mfg Co Ltd Alkyl phenyl ketone derivative
WO2009050116A2 (en) * 2007-10-17 2009-04-23 Basf Se Adhesion promoting photoinitiators for uv cured coatings over metal surfaces
CN101952273B (zh) * 2008-02-12 2014-11-12 柳韩洋行 2-甲基2’-苯基丙酸衍生物的制备方法和中间体化合物
CN102675101B (zh) 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CN103159674A (zh) * 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
CN104151160A (zh) 2013-05-15 2014-11-19 重庆华邦制药有限公司 用酯类化合物合成2-甲基丙酸酯衍生物的方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN104326909A (zh) 2014-09-22 2015-02-04 暨南大学 一种制备α,α-二甲基-4-(2-卤乙基)苯乙酸酯及合成比拉斯汀的方法

Also Published As

Publication number Publication date
CY1124909T1 (el) 2023-01-05
US20210300856A1 (en) 2021-09-30
PH12021550144A1 (en) 2021-09-13
KR20210038905A (ko) 2021-04-08
HUE056822T2 (hu) 2022-03-28
SI3826997T1 (sl) 2022-01-31
EP3599235A1 (en) 2020-01-29
JP2021531300A (ja) 2021-11-18
AU2019311251B2 (en) 2021-10-21
CO2021000940A2 (es) 2021-02-17
CL2021000171A1 (es) 2021-07-09
MA53370A (fr) 2021-06-02
US11370742B2 (en) 2022-06-28
PT3826997T (pt) 2022-01-21
ZA202101214B (en) 2022-09-28
AU2019311251A1 (en) 2021-03-04
MA53370B1 (fr) 2021-12-31
EP3826997A1 (en) 2021-06-02
HRP20211994T1 (hr) 2022-04-01
PE20211243A1 (es) 2021-07-13
JP7145312B2 (ja) 2022-09-30
ES2901786T3 (es) 2022-03-23
ECSP21008461A (es) 2021-03-31
CN112469709A (zh) 2021-03-09
EP3826997B1 (en) 2021-11-10
SG11202100576WA (en) 2021-02-25
LT3826997T (lt) 2021-12-27
CA3107879A1 (en) 2020-01-30
MX2021000924A (es) 2021-03-31
WO2020020873A1 (en) 2020-01-30
PL3826997T3 (pl) 2022-05-30
BR112021001179A2 (pt) 2021-04-27

Similar Documents

Publication Publication Date Title
EA202190346A1 (ru) Способ и промежуточные продукты получения биластина
EA202090917A1 (ru) Получение псилоцибина, различных полиморфных форм, промежуточных соединений, составов и их применение
PH12019502264A1 (en) Fused imidazo-piperidine jak inhibitors compound
CY1114213T1 (el) Μεθοδοι απομονωσης κρυσταλλικης μορφης ι της 5-αζακυτιδινης
CY1113799T1 (el) Παρασκευη δελμοπινολης
EA201992421A1 (ru) Способ получения озанимода
MX2013011257A (es) Proceso para la preparacion de dronedarona por n-butilacion.
IN2014MN01521A (ru)
EA202091466A1 (ru) Синтез сокристалла 1:1:1 1-циано-2-(4-циклопропилбензил)-4-(-d-глюкопираноз-1-ил)бензола, l-пролина и воды
HRP20080554B1 (hr) Postupak priprave inhibitora proteaze hiv
EA201301315A1 (ru) Способ получения промежуточных соединений эстетрола
FR3087439B1 (fr) Procédé pour la préparation de 3α-hydroxy-5α-prégnan-20-one (brexanolone)
EA201892515A1 (ru) Стероидные 6,7-бета-эпоксиды в качестве интермедиатов
PE20191103A1 (es) Inhibidores de dopamina-b-hidroxilasa
EP4001266A3 (en) Process for preparing methoxy methyl pyridine dicarboxylate
EA201171167A1 (ru) Карбинольное соединение, содержащее гетероциклический линкер
BR112022012153A2 (pt) Processo para preparar um composto e composto
ATE428693T1 (de) Prostaglandinsynthese
EA202192840A1 (ru) Способ получения соединений карбамоилоксиметилтриазолциклогексиловой кислоты
EA202190330A1 (ru) Способ получения полиморфной формы робенакоксиба
EA202091927A1 (ru) Гидрохлорид производного бензодиазепина и кристаллическая форма, способ их получения и применения
MX2021006692A (es) Proceso mejorado para preparar ozanimod.
EA202192639A1 (ru) Способ получения сипонимода и его промежуточного соединения
ZA202202879B (en) Process for preparing an e-selectin inhibitor intermediate
MX2022009778A (es) Polimorfos de elafibranor.