EA201992421A1 - Способ получения озанимода - Google Patents
Способ получения озанимодаInfo
- Publication number
- EA201992421A1 EA201992421A1 EA201992421A EA201992421A EA201992421A1 EA 201992421 A1 EA201992421 A1 EA 201992421A1 EA 201992421 A EA201992421 A EA 201992421A EA 201992421 A EA201992421 A EA 201992421A EA 201992421 A1 EA201992421 A1 EA 201992421A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ozanimoda
- obtaining
- new
- ozanimod
- preparation
- Prior art date
Links
- XRVDGNKRPOAQTN-FQEVSTJZSA-N 5-[3-[(1s)-1-(2-hydroxyethylamino)-2,3-dihydro-1h-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxybenzonitrile Chemical compound C1=C(C#N)C(OC(C)C)=CC=C1C1=NC(C=2C=3CC[C@@H](C=3C=CC=2)NCCO)=NO1 XRVDGNKRPOAQTN-FQEVSTJZSA-N 0.000 abstract 2
- 229950008141 ozanimod Drugs 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Настоящее изобретение относится к новому способу получения озанимода указанной формулы и его солей присоединения кислоты посредством новых промежуточных соединений и к новой полиморфной форме озанимода основания.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP1700216 | 2017-05-22 | ||
PCT/HU2018/050019 WO2018215807A1 (en) | 2017-05-22 | 2018-05-18 | Process for the production of ozanimod |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992421A1 true EA201992421A1 (ru) | 2020-03-27 |
Family
ID=89720175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992421A EA201992421A1 (ru) | 2017-05-22 | 2018-05-18 | Способ получения озанимода |
Country Status (11)
Country | Link |
---|---|
US (1) | US20200087269A1 (ru) |
EP (1) | EP3630738B1 (ru) |
CN (1) | CN110997645B (ru) |
EA (1) | EA201992421A1 (ru) |
ES (1) | ES2960051T3 (ru) |
HR (1) | HRP20231308T1 (ru) |
MA (1) | MA48798B1 (ru) |
PL (1) | PL3630738T3 (ru) |
PT (1) | PT3630738T (ru) |
SI (1) | SI3630738T1 (ru) |
WO (1) | WO2018215807A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019094409A1 (en) * | 2017-11-07 | 2019-05-16 | Teva Pharmaceuticals International Gmbh | Salts and solid state forms of ozanimod |
EP3891133B1 (en) * | 2018-12-07 | 2023-06-07 | Synthon B.V. | Improved process for preparing ozanimod |
WO2020152718A1 (en) * | 2019-01-25 | 2020-07-30 | Mylan Laboratories Limited | Polymorphic forms 5-[3-[(1s)-2,3-dihydro-1-[(2-hydroxyethyl) amino]-1h-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile |
CN112062785B (zh) * | 2019-06-11 | 2023-06-27 | 广东东阳光药业有限公司 | 奥扎莫德及其中间体的制备方法 |
EP3999495A1 (en) | 2019-07-16 | 2022-05-25 | Synthon B.V. | Improved process for preparing ozanimod |
TW202131921A (zh) | 2019-10-31 | 2021-09-01 | 瑞士商愛杜西亞製藥有限公司 | Cxcr7拮抗劑與s1p1受體調節劑之組合 |
WO2021197852A1 (en) * | 2020-04-02 | 2021-10-07 | Synthon B.V. | Crystalline form of ozanimod hydrochloride |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2776242C (en) * | 2009-10-08 | 2014-09-02 | Sanofi | Phenyloxadiazole derivatives as pgds inhibitors |
WO2011060392A1 (en) * | 2009-11-13 | 2011-05-19 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
WO2017215617A1 (zh) * | 2016-06-14 | 2017-12-21 | 苏州科睿思制药有限公司 | 奥扎莫德的晶型、其盐酸盐的晶型及其制备方法 |
CN109563059A (zh) * | 2016-08-19 | 2019-04-02 | 苏州科睿思制药有限公司 | 奥扎莫德的晶型及其制备方法 |
US11117875B2 (en) * | 2016-09-14 | 2021-09-14 | Hangzhou Solipharma Co., Ltd. | Crystalline forms, preparation methods and pharmaceutical compositions of ozanimod |
JP7086945B2 (ja) * | 2016-09-29 | 2022-06-20 | レセプトス・リミテッド・ライアビリティ・カンパニー | 狼瘡を処置するための化合物および方法 |
-
2018
- 2018-05-18 EP EP18806925.6A patent/EP3630738B1/en active Active
- 2018-05-18 PT PT188069256T patent/PT3630738T/pt unknown
- 2018-05-18 HR HRP20231308TT patent/HRP20231308T1/hr unknown
- 2018-05-18 MA MA48798A patent/MA48798B1/fr unknown
- 2018-05-18 WO PCT/HU2018/050019 patent/WO2018215807A1/en unknown
- 2018-05-18 ES ES18806925T patent/ES2960051T3/es active Active
- 2018-05-18 SI SI201831007T patent/SI3630738T1/sl unknown
- 2018-05-18 EA EA201992421A patent/EA201992421A1/ru unknown
- 2018-05-18 CN CN201880049683.6A patent/CN110997645B/zh active Active
- 2018-05-18 PL PL18806925.6T patent/PL3630738T3/pl unknown
- 2018-05-18 US US16/615,468 patent/US20200087269A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3630738A4 (en) | 2021-03-10 |
EP3630738A1 (en) | 2020-04-08 |
HRP20231308T1 (hr) | 2024-04-26 |
CN110997645B (zh) | 2023-10-10 |
ES2960051T3 (es) | 2024-02-29 |
PL3630738T3 (pl) | 2024-04-08 |
CN110997645A (zh) | 2020-04-10 |
WO2018215807A1 (en) | 2018-11-29 |
MA48798B1 (fr) | 2023-10-31 |
MA48798A (fr) | 2020-04-08 |
PT3630738T (pt) | 2023-10-24 |
SI3630738T1 (sl) | 2024-02-29 |
EP3630738B1 (en) | 2023-07-19 |
US20200087269A1 (en) | 2020-03-19 |
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