MA48798B1 - Procédé de production d'ozanimod - Google Patents

Procédé de production d'ozanimod

Info

Publication number
MA48798B1
MA48798B1 MA48798A MA48798A MA48798B1 MA 48798 B1 MA48798 B1 MA 48798B1 MA 48798 A MA48798 A MA 48798A MA 48798 A MA48798 A MA 48798A MA 48798 B1 MA48798 B1 MA 48798B1
Authority
MA
Morocco
Prior art keywords
ozanimod
production process
new
polimop
formula
Prior art date
Application number
MA48798A
Other languages
English (en)
Other versions
MA48798A (fr
Inventor
Márta Porcs-Makkay
Gyula Simig
Eniko Molnár
Balázs Volk
László Szlávik
Éva Szabó
Judit Halász
János Pethö
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of MA48798A publication Critical patent/MA48798A/fr
Publication of MA48798B1 publication Critical patent/MA48798B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un nouveau procédé pour la préparation d'ozanimod de formule et de sels d'addition d'acide, par le biais de nouveaux intermédiaires et d'une nouvelle forme polimop à base d'ozanimod.
MA48798A 2017-05-22 2018-05-18 Procédé de production d'ozanimod MA48798B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1700216 2017-05-22
PCT/HU2018/050019 WO2018215807A1 (fr) 2017-05-22 2018-05-18 Procédé de production d'ozanimod

Publications (2)

Publication Number Publication Date
MA48798A MA48798A (fr) 2020-04-08
MA48798B1 true MA48798B1 (fr) 2023-10-31

Family

ID=89720175

Family Applications (1)

Application Number Title Priority Date Filing Date
MA48798A MA48798B1 (fr) 2017-05-22 2018-05-18 Procédé de production d'ozanimod

Country Status (12)

Country Link
US (1) US20200087269A1 (fr)
EP (1) EP3630738B1 (fr)
CN (1) CN110997645B (fr)
EA (1) EA201992421A1 (fr)
ES (1) ES2960051T3 (fr)
HR (1) HRP20231308T1 (fr)
HU (1) HUE064642T2 (fr)
MA (1) MA48798B1 (fr)
PL (1) PL3630738T3 (fr)
PT (1) PT3630738T (fr)
SI (1) SI3630738T1 (fr)
WO (1) WO2018215807A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019094409A1 (fr) * 2017-11-07 2019-05-16 Teva Pharmaceuticals International Gmbh Sels et formes à l'état solide d'ozanimod
ES2962211T3 (es) * 2018-12-07 2024-03-18 Synthon Bv Proceso mejorado para preparar ozanimod
WO2020152718A1 (fr) * 2019-01-25 2020-07-30 Mylan Laboratories Limited Formes polymorphes de 5-[3-[(1s)-2,3-dihydro-1-[(2-hydroxyéthyl) amino]-1h-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-méthyléthoxy)benzonitrile
CN112062785B (zh) * 2019-06-11 2023-06-27 广东东阳光药业有限公司 奥扎莫德及其中间体的制备方法
EP3999495A1 (fr) 2019-07-16 2022-05-25 Synthon B.V. Procédé amélioré de préparation d'ozanimod
CN114599363A (zh) 2019-10-31 2022-06-07 爱杜西亚药品有限公司 Cxcr7拮抗剂与s1p1受体调节剂的组合
EP4126826A1 (fr) * 2020-04-02 2023-02-08 Synthon B.V. Forme cristalline d'hydrochlorure d'ozanimod
EP4212156A1 (fr) 2022-01-13 2023-07-19 Abivax Combinaison de 8-chloro-n-(4-(trifluorométhoxy)phényl)quinolin-2-amine et de ses dérivés avec un modulateur de récepteur de s1p

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2776242C (fr) * 2009-10-08 2014-09-02 Sanofi Derives de phenyloxadiazole en tant qu'inhibiteurs de pgds
CN102762100B (zh) * 2009-11-13 2015-07-01 瑞塞普托斯公司 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法
WO2015066515A1 (fr) * 2013-11-01 2015-05-07 Receptos, Inc. Modulateurs sélectifs des récepteurs de la sphingosine-1-phosphate et traitement combiné les utilisant
CN114957157A (zh) * 2016-06-14 2022-08-30 瑞塞普托斯有限责任公司 奥扎莫德盐酸盐的晶型及其制备方法
US11028060B2 (en) * 2016-08-19 2021-06-08 Receptos Llc Crystalline forms of ozanimod and processes for preparation thereof
US11117875B2 (en) * 2016-09-14 2021-09-14 Hangzhou Solipharma Co., Ltd. Crystalline forms, preparation methods and pharmaceutical compositions of ozanimod
EP3518922A1 (fr) * 2016-09-29 2019-08-07 Celgene International II Sarl Composés et méthodes pour le traitement de l'inflammation

Also Published As

Publication number Publication date
EP3630738B1 (fr) 2023-07-19
CN110997645A (zh) 2020-04-10
ES2960051T3 (es) 2024-02-29
HRP20231308T1 (hr) 2024-04-26
MA48798A (fr) 2020-04-08
SI3630738T1 (sl) 2024-02-29
CN110997645B (zh) 2023-10-10
WO2018215807A1 (fr) 2018-11-29
EA201992421A1 (ru) 2020-03-27
US20200087269A1 (en) 2020-03-19
EP3630738A1 (fr) 2020-04-08
PL3630738T3 (pl) 2024-04-08
EP3630738A4 (fr) 2021-03-10
PT3630738T (pt) 2023-10-24
HUE064642T2 (hu) 2024-04-28

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