PE20221420A1 - Procedimiento fotoquimico para la preparacion de (4r,4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida - Google Patents

Procedimiento fotoquimico para la preparacion de (4r,4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida

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Publication number
PE20221420A1
PE20221420A1 PE2022000636A PE2022000636A PE20221420A1 PE 20221420 A1 PE20221420 A1 PE 20221420A1 PE 2022000636 A PE2022000636 A PE 2022000636A PE 2022000636 A PE2022000636 A PE 2022000636A PE 20221420 A1 PE20221420 A1 PE 20221420A1
Authority
PE
Peru
Prior art keywords
methoxyphenyl
dihydro
cyano
dimethyl
carboxamide
Prior art date
Application number
PE2022000636A
Other languages
English (en)
Inventor
Johannes Platzek
Kai Lovis
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20221420A1 publication Critical patent/PE20221420A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invencion se refiere a un procedimiento para preparar (4R,4S)-4-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida racemica de la formula (I) a partir de los enantiomeros (Ia) o (Ib); a un procedimiento para preparar (4S)-4- (4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida de la formula (Ia).
PE2022000636A 2019-10-17 2020-10-12 Procedimiento fotoquimico para la preparacion de (4r,4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida PE20221420A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19203824 2019-10-17
PCT/EP2020/078614 WO2021074079A1 (de) 2019-10-17 2020-10-12 Photochemisches verfahren zur herstellung von (4r, 4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid

Publications (1)

Publication Number Publication Date
PE20221420A1 true PE20221420A1 (es) 2022-09-20

Family

ID=68281312

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022000636A PE20221420A1 (es) 2019-10-17 2020-10-12 Procedimiento fotoquimico para la preparacion de (4r,4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida

Country Status (14)

Country Link
EP (1) EP4045502A1 (es)
JP (1) JP2022553224A (es)
KR (1) KR20220084104A (es)
CN (1) CN114555598A (es)
AU (1) AU2020365351A1 (es)
BR (1) BR112022005899A2 (es)
CA (1) CA3158167A1 (es)
CO (1) CO2022004463A2 (es)
CR (1) CR20220158A (es)
IL (1) IL292191A (es)
JO (1) JOP20220090A1 (es)
MX (1) MX2022004466A (es)
PE (1) PE20221420A1 (es)
WO (1) WO2021074079A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114524812A (zh) * 2022-03-18 2022-05-24 湖南凯铂生物药业有限公司 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
WO2024022481A1 (zh) * 2022-07-29 2024-02-01 苏中药业集团股份有限公司 苯基取代的二氢萘啶类化合物及其制备与用途
CN115583866A (zh) * 2022-08-30 2023-01-10 上海厚博生物科技有限公司 一种用非奈利酮对映体制备非奈利酮的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
GB201317609D0 (en) * 2013-10-04 2013-11-20 Cancer Rec Tech Ltd Inhibitor compounds
DK3174875T3 (da) * 2014-08-01 2020-11-16 Bayer Pharma AG Fremgangsmåde til fremstilling af (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid og dets oprensning til anvendelse som farmaceutisk aktivstof
SG11201801378VA (en) * 2015-08-21 2018-03-28 Bayer Pharma AG Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carboxamide and recovery of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carboxamide by electrochemical methods
WO2017032627A1 (de) * 2015-08-21 2017-03-02 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung der metaboliten von (4s) und (4r)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxamid und deren verwendung

Also Published As

Publication number Publication date
JP2022553224A (ja) 2022-12-22
AU2020365351A1 (en) 2022-05-12
BR112022005899A2 (pt) 2022-06-28
WO2021074079A1 (de) 2021-04-22
MX2022004466A (es) 2022-05-03
EP4045502A1 (de) 2022-08-24
KR20220084104A (ko) 2022-06-21
CA3158167A1 (en) 2021-04-22
CN114555598A (zh) 2022-05-27
IL292191A (en) 2022-06-01
CO2022004463A2 (es) 2022-04-29
JOP20220090A1 (ar) 2023-01-30
CR20220158A (es) 2022-06-15

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