UY38197A - Procedimiento para preparar (4s)-4-(4-ciano-2-metoxifenil)-5 etoxi-2,8-dimetil-1,4-dihidro-1,6-nafti - Google Patents

Procedimiento para preparar (4s)-4-(4-ciano-2-metoxifenil)-5 etoxi-2,8-dimetil-1,4-dihidro-1,6-nafti

Info

Publication number
UY38197A
UY38197A UY0001038197A UY38197A UY38197A UY 38197 A UY38197 A UY 38197A UY 0001038197 A UY0001038197 A UY 0001038197A UY 38197 A UY38197 A UY 38197A UY 38197 A UY38197 A UY 38197A
Authority
UY
Uruguay
Prior art keywords
dihydro
dimethyl
metoxyphenil
nafti
cyane
Prior art date
Application number
UY0001038197A
Other languages
English (en)
Inventor
Johannes Platzek Dr
Kai Lovis Dr
Winfried Joentgen Dr
Original Assignee
Bayer Pharma AG
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Ag filed Critical Bayer Pharma AG
Publication of UY38197A publication Critical patent/UY38197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida de la fórmula (I) (I) ,y la preparación del enantiómero (Ia) por separación de racemato con ésteres del ácido tartárico sustituidos quiralmente de las fórmulas generales (IIIa) y (IIIb) (Ia) (llla) (IIIb) donde Ar es un compuesto aromático o heteroaromático sustituido o no sustituido.
UY0001038197A 2018-04-24 2019-04-24 Procedimiento para preparar (4s)-4-(4-ciano-2-metoxifenil)-5 etoxi-2,8-dimetil-1,4-dihidro-1,6-nafti UY38197A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18169052.0A EP3560922A1 (de) 2018-04-24 2018-04-24 Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester

Publications (1)

Publication Number Publication Date
UY38197A true UY38197A (es) 2019-11-29

Family

ID=62062935

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001038197A UY38197A (es) 2018-04-24 2019-04-24 Procedimiento para preparar (4s)-4-(4-ciano-2-metoxifenil)-5 etoxi-2,8-dimetil-1,4-dihidro-1,6-nafti

Country Status (19)

Country Link
US (1) US12054481B2 (es)
EP (2) EP3560922A1 (es)
JP (1) JP7394785B2 (es)
KR (1) KR20210005000A (es)
CN (1) CN112041318A (es)
AR (1) AR114833A1 (es)
AU (1) AU2019258116B2 (es)
BR (1) BR112020018738A2 (es)
CA (1) CA3097924A1 (es)
CL (1) CL2020002742A1 (es)
CO (1) CO2020013150A2 (es)
IL (1) IL278078B2 (es)
JO (1) JOP20200267A1 (es)
MX (1) MX2020011198A (es)
PE (1) PE20211903A1 (es)
SG (1) SG11202010504QA (es)
TW (1) TW202003514A (es)
UY (1) UY38197A (es)
WO (1) WO2019206909A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20221415A1 (es) * 2019-10-17 2022-09-20 Bayer Ag Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxi-fenil)-5-hidroxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilato de 2-cianoetilo por separacion de racematos por medio de ester de acido tartarico diastereoisomero
TW202214624A (zh) 2020-06-16 2022-04-16 德商拜耳廠股份有限公司 藉由催化不對稱漢斯（ｈａｎｔｚｓｃｈ）酯還原法進行之製備（４ｓ）－４－（４－氰基－２－甲氧基苯基）－５－乙氧基－２，８－二甲基－１，４－二氫－１，６－㖠啶－３－羧醯胺的方法
CN115340539B (zh) * 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN115340540A (zh) * 2022-01-20 2022-11-15 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN114605410B (zh) * 2022-04-06 2023-12-29 浙江科聚生物医药有限公司 一种非奈利酮原料药的制备方法
WO2023205164A1 (en) 2022-04-18 2023-10-26 Teva Pharmaceuticals International Gmbh Processes for the preparation of finerenone
WO2023223188A1 (en) * 2022-05-16 2023-11-23 Glenmark Life Sciences Limited Process for the preparation of finerenone and intermediates thereof
WO2024075139A1 (en) * 2022-10-06 2024-04-11 Maithri Drugs Private Limited A process for preparation of finerenone and intermediates thereof
CN117986250A (zh) * 2022-11-04 2024-05-07 南京威凯尔生物医药科技有限公司 通过非对映酒石酸酯拆分外消旋体制备非奈利酮的方法
WO2024126694A1 (en) 2022-12-16 2024-06-20 Bayer Aktiengesellschaft Sequential one-pot synthesis for preparing 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
WO2024147053A1 (en) * 2023-01-03 2024-07-11 Optimus Drugs Pvt Ltd Improved process for the preparation of finerenone
WO2024193455A1 (zh) * 2023-03-17 2024-09-26 江苏恒瑞医药股份有限公司 一种1,4-二氢-1,6-萘啶酰胺化合物的可药用盐、晶型及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3906460C1 (es) 1989-03-01 1990-11-15 Goedecke Ag, 1000 Berlin, De
WO2006059886A1 (en) 2004-12-02 2006-06-08 Sk Chemicals, Co., Ltd. Optical resolution method of amlodipine
JP5247466B2 (ja) * 2005-12-22 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション ６，６−ジメチル−３−アザビシクロ−［３．１．０］−ヘキサン化合物およびその鏡像異性体塩を調製するプロセス
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
CN101648903A (zh) 2009-09-17 2010-02-17 南京大学 一种制备光学活性的氨氯地平对甲苯磺酸盐的方法
CN101798280B (zh) 2010-03-22 2012-05-02 河北师范大学 一种手性拆分消旋体氨氯地平制备s-(-)-氨氯地平和r-(+)-氨氯地平的方法
AU2015295376C1 (en) 2014-08-01 2020-07-16 Bayer Pharma Aktiengesellschaft Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient
CN107849043B (zh) * 2015-08-21 2020-10-16 拜耳制药股份公司 用于制备(4s)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氢-1,6-萘啶-3-甲酰胺的方法
PE20180555A1 (es) 2015-08-21 2018-04-02 Bayer Pharma AG Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida y para la recuperacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridina-3-carboxamida por medio de metodos electroquimicos

Also Published As

Publication number Publication date
US20210163474A1 (en) 2021-06-03
JOP20200267A1 (ar) 2020-10-25
IL278078B2 (en) 2023-10-01
IL278078B1 (en) 2023-06-01
PE20211903A1 (es) 2021-09-27
CN112041318A (zh) 2020-12-04
US12054481B2 (en) 2024-08-06
KR20210005000A (ko) 2021-01-13
AU2019258116A1 (en) 2020-11-05
AR114833A1 (es) 2020-10-21
JP7394785B2 (ja) 2023-12-08
JP2021522236A (ja) 2021-08-30
EP3784668A1 (de) 2021-03-03
WO2019206909A1 (de) 2019-10-31
CA3097924A1 (en) 2019-10-31
SG11202010504QA (en) 2020-11-27
TW202003514A (zh) 2020-01-16
IL278078A (en) 2020-11-30
MX2020011198A (es) 2020-11-13
BR112020018738A2 (pt) 2021-01-05
AU2019258116B2 (en) 2024-07-25
CO2020013150A2 (es) 2020-11-10
EP3560922A1 (de) 2019-10-30
CL2020002742A1 (es) 2021-01-15

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