MX2018010199A - Proceso para la separacion de enantiomeros de derivados de piperazina. - Google Patents

Proceso para la separacion de enantiomeros de derivados de piperazina.

Info

Publication number
MX2018010199A
MX2018010199A MX2018010199A MX2018010199A MX2018010199A MX 2018010199 A MX2018010199 A MX 2018010199A MX 2018010199 A MX2018010199 A MX 2018010199A MX 2018010199 A MX2018010199 A MX 2018010199A MX 2018010199 A MX2018010199 A MX 2018010199A
Authority
MX
Mexico
Prior art keywords
enantiomers
separation
piperazine derivatives
chiral
enantiomer
Prior art date
Application number
MX2018010199A
Other languages
English (en)
Inventor
S Kulkarni Santosh
Gajendra Giri Awadut
Quattropani Anna
Nicolaas Koek Johannes
Original Assignee
Asceneuron S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asceneuron S A filed Critical Asceneuron S A
Publication of MX2018010199A publication Critical patent/MX2018010199A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un proceso para preparar cualquier enantiómero de un compuesto de fórmula (I), en donde X, Y y n tienen el significado que se da en la reivindicación 1, con un exceso enantiomérico (e.e.) por resolución quiral en presencia de un ácido quiral no racémico.
MX2018010199A 2016-02-25 2017-02-24 Proceso para la separacion de enantiomeros de derivados de piperazina. MX2018010199A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201621006637 2016-02-25
PCT/EP2017/054272 WO2017144635A1 (en) 2016-02-25 2017-02-24 Process for the separation of enantiomers of piperazine derivatives

Publications (1)

Publication Number Publication Date
MX2018010199A true MX2018010199A (es) 2019-05-20

Family

ID=58159075

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010199A MX2018010199A (es) 2016-02-25 2017-02-24 Proceso para la separacion de enantiomeros de derivados de piperazina.

Country Status (12)

Country Link
US (1) US10344021B2 (es)
EP (1) EP3419974B1 (es)
JP (1) JP2019510007A (es)
KR (1) KR20180132059A (es)
CN (1) CN108884081B (es)
AU (1) AU2017222960A1 (es)
BR (1) BR112018017213A2 (es)
CA (1) CA3014376A1 (es)
EA (1) EA201891437A1 (es)
MX (1) MX2018010199A (es)
SG (1) SG11201807005VA (es)
WO (1) WO2017144635A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA53944A (fr) 2014-08-28 2021-08-25 Asceneuron Sa Inhibiteurs de la glycosidase
ES2879351T3 (es) 2016-02-25 2021-11-22 Asceneuron Sa Sales de derivados de piperazina obtenidas por adición de ácidos
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
EP3419971B1 (en) 2016-02-25 2022-04-20 Asceneuron SA Glycosidase inhibitors
WO2017144639A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
WO2019037860A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. LINEAR INHIBITORS OF GLYCOSIDASE
WO2020039029A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Spiro compounds as glycosidase inhibitors
WO2020039028A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Tetrahydro-benzoazepine glycosidase inhibitors
US12016852B2 (en) 2018-08-22 2024-06-25 Asceneuron Sa Pyrrolidine glycosidase inhibitors
CN109374808B (zh) * 2018-11-08 2020-09-29 上海明捷医药科技有限公司 测定琥珀酸索利钠新原料药中苯胺类基因毒性杂质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1311316A (fr) 1961-04-12 1962-12-07 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
IL158941A0 (en) * 2001-05-22 2004-05-12 Neurogen Corp Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
AR065494A1 (es) * 2007-03-02 2009-06-10 Schering Corp Derivados de piperidina y metodos de uso de los mismos
DK2970272T3 (en) * 2013-03-14 2019-04-23 Merck Patent Gmbh glycosidase
MA53944A (fr) 2014-08-28 2021-08-25 Asceneuron Sa Inhibiteurs de la glycosidase

Also Published As

Publication number Publication date
SG11201807005VA (en) 2018-09-27
US10344021B2 (en) 2019-07-09
BR112018017213A2 (pt) 2019-01-02
CN108884081A (zh) 2018-11-23
CA3014376A1 (en) 2017-08-31
CN108884081B (zh) 2022-11-01
AU2017222960A1 (en) 2018-08-16
KR20180132059A (ko) 2018-12-11
WO2017144635A1 (en) 2017-08-31
EP3419974B1 (en) 2021-05-05
JP2019510007A (ja) 2019-04-11
US20190062316A1 (en) 2019-02-28
EA201891437A1 (ru) 2019-03-29
EP3419974A1 (en) 2019-01-02

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