CL2022000941A1 - Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxílico - Google Patents

Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxílico

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Publication number
CL2022000941A1
CL2022000941A1 CL2022000941A CL2022000941A CL2022000941A1 CL 2022000941 A1 CL2022000941 A1 CL 2022000941A1 CL 2022000941 A CL2022000941 A CL 2022000941A CL 2022000941 A CL2022000941 A CL 2022000941A CL 2022000941 A1 CL2022000941 A1 CL 2022000941A1
Authority
CL
Chile
Prior art keywords
preparing
naphthyridine
methoxyphenyl
dihydro
ethoxy
Prior art date
Application number
CL2022000941A
Other languages
English (en)
Inventor
Johannes Platzek
Kai Lovis
Martin Alba Hernandez
Silja Brady
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CL2022000941A1 publication Critical patent/CL2022000941A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para preparar ésteres aciloximetílicos del ácido (4S)–(4– ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxílico de la fórmula (IIa) por separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. La invención se refiere también a un procedimiento para preparar (4S)–4–(4–ciano–2–metoxifenil)–5–etoxi–2,8–dimetil–1,4–dihidro–1,6– naftiridin–3–carboxamida de la fórmula (Ia), en donde el procedimiento comprende la separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. Además, la invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (IIa). La invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (Ia).
CL2022000941A 2019-10-17 2022-04-13 Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxílico CL2022000941A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19203821 2019-10-17

Publications (1)

Publication Number Publication Date
CL2022000941A1 true CL2022000941A1 (es) 2022-11-11

Family

ID=68281309

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022000941A CL2022000941A1 (es) 2019-10-17 2022-04-13 Procedimiento para preparar ésteres aciloximetílicos del ácido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxílico

Country Status (15)

Country Link
US (1) US20240150344A1 (es)
EP (1) EP4045500A1 (es)
JP (1) JP2022553225A (es)
KR (1) KR20220084102A (es)
AU (1) AU2020365314A1 (es)
BR (1) BR112022005605A2 (es)
CA (1) CA3157823A1 (es)
CL (1) CL2022000941A1 (es)
CO (1) CO2022004464A2 (es)
CR (1) CR20220161A (es)
IL (1) IL292194A (es)
JO (1) JOP20220148A1 (es)
MX (1) MX2022004480A (es)
PE (1) PE20221414A1 (es)
WO (1) WO2021074077A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114214375B (zh) * 2021-12-27 2024-03-19 江苏威凯尔医药科技有限公司 (r)-3-(4-卤代-1h-吡唑-1-基)-3-环戊基丙酸酯的制备方法
CN115340539B (zh) * 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
WO2023205164A1 (en) 2022-04-18 2023-10-26 Teva Pharmaceuticals International Gmbh Processes for the preparation of finerenone
WO2023223188A1 (en) * 2022-05-16 2023-11-23 Glenmark Life Sciences Limited Process for the preparation of finerenone and intermediates thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
CA3146285C (en) * 2014-08-01 2024-01-02 Bayer Pharma Aktiengesellschaft Method for the preparation of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient

Also Published As

Publication number Publication date
PE20221414A1 (es) 2022-09-20
AU2020365314A1 (en) 2022-05-12
US20240150344A1 (en) 2024-05-09
JOP20220148A1 (ar) 2023-01-30
CA3157823A1 (en) 2021-04-22
BR112022005605A2 (pt) 2022-07-19
WO2021074077A1 (de) 2021-04-22
JP2022553225A (ja) 2022-12-22
MX2022004480A (es) 2022-05-06
CN114555599A (zh) 2022-05-27
EP4045500A1 (de) 2022-08-24
CO2022004464A2 (es) 2022-04-29
CR20220161A (es) 2022-06-17
IL292194A (en) 2022-06-01
KR20220084102A (ko) 2022-06-21

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