CL2012000159A1 - Procedimiento para la preparacion estereoselectiva de compuestos (trans)- y (cis)-9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, y los compuestos intermediarios considerados. - Google Patents

Procedimiento para la preparacion estereoselectiva de compuestos (trans)- y (cis)-9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, y los compuestos intermediarios considerados.

Info

Publication number
CL2012000159A1
CL2012000159A1 CL2012000159A CL2012000159A CL2012000159A1 CL 2012000159 A1 CL2012000159 A1 CL 2012000159A1 CL 2012000159 A CL2012000159 A CL 2012000159A CL 2012000159 A CL2012000159 A CL 2012000159A CL 2012000159 A1 CL2012000159 A1 CL 2012000159A1
Authority
CL
Chile
Prior art keywords
compounds
procedure
undecan
quinazolin
diaza
Prior art date
Application number
CL2012000159A
Other languages
English (en)
Inventor
Guenther Huchler
Markus Ostermeier
Juergen Daeubler
Stephan Kling
Marco Santagostino
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2012000159A1 publication Critical patent/CL2012000159A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACIÓN ESTEREOSELECTIVA DE COMPUESTOS DE LAS FÓRMULAS (LA) Y (LB) Y DEL COMPUESTO INTERMEDIARIO DE FÓRMULA (18); YA LOS COMPUESTOS INTERMEDIARIOS DE FÓRMULA (4), (5), (6), (12), (13) Y (22).<br />  
CL2012000159A 2009-08-06 2012-01-19 Procedimiento para la preparacion estereoselectiva de compuestos (trans)- y (cis)-9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, y los compuestos intermediarios considerados. CL2012000159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09167393A EP2289881A1 (de) 2009-08-06 2009-08-06 Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen

Publications (1)

Publication Number Publication Date
CL2012000159A1 true CL2012000159A1 (es) 2012-08-31

Family

ID=41205591

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000159A CL2012000159A1 (es) 2009-08-06 2012-01-19 Procedimiento para la preparacion estereoselectiva de compuestos (trans)- y (cis)-9-[4-(3-cloro-2-fluoro-fenilamino)-7-metoxi-quinazolin-6-iloxi]-1,4-diaza-espiro[5.5]undecan-5-ona, y los compuestos intermediarios considerados.

Country Status (21)

Country Link
US (2) US8658790B2 (es)
EP (2) EP2289881A1 (es)
JP (1) JP2013501025A (es)
KR (1) KR20120049248A (es)
CN (1) CN102471288B (es)
AR (1) AR077797A1 (es)
AU (1) AU2010280852B2 (es)
BR (1) BR112012002104A2 (es)
CA (1) CA2767963A1 (es)
CL (1) CL2012000159A1 (es)
DK (1) DK2462126T3 (es)
EA (1) EA023562B1 (es)
ES (1) ES2549770T3 (es)
HU (1) HUE025400T2 (es)
IL (1) IL216969A (es)
MX (1) MX2012001089A (es)
NZ (1) NZ597698A (es)
PL (1) PL2462126T3 (es)
TW (1) TW201120013A (es)
UY (1) UY32830A (es)
WO (1) WO2011015526A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AU2012213556A1 (en) * 2011-02-01 2013-08-22 Boehringer Ingelheim International Gmbh 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
BR112014019196A8 (pt) 2012-02-09 2017-07-11 Boehringer Ingelheim Int Método para síntese estereosseletiva de 9-hidróxi-5-oxo-1,4-diaza-espiro[5.5]undecanos 1,4-protegidos
EP2875020B1 (en) * 2012-07-19 2017-09-06 Boehringer Ingelheim International GmbH Process for the preparation of a fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one
WO2021198188A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324597B (en) 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
KR20090116782A (ko) * 2007-02-06 2009-11-11 베링거 인겔하임 인터내셔날 게엠베하 바이사이클릭 헤테로사이클, 당해 화합물을 함유하는 약물, 이의 용도 및 이의 제조방법
WO2009054479A1 (ja) * 2007-10-26 2009-04-30 Japan Tobacco Inc. スピロ環化合物及びその医薬用途
KR20100111291A (ko) * 2008-02-07 2010-10-14 베링거 인겔하임 인터내셔날 게엠베하 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법
US8263768B2 (en) * 2008-08-08 2012-09-11 Boehringer Ingelheim International Gmbh Process for the stereoselective preparation of bicyclic heterocycles
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AU2012213556A1 (en) 2011-02-01 2013-08-22 Boehringer Ingelheim International Gmbh 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
BR112014019196A8 (pt) * 2012-02-09 2017-07-11 Boehringer Ingelheim Int Método para síntese estereosseletiva de 9-hidróxi-5-oxo-1,4-diaza-espiro[5.5]undecanos 1,4-protegidos

Also Published As

Publication number Publication date
AU2010280852A1 (en) 2012-02-09
US20140135495A1 (en) 2014-05-15
IL216969A (en) 2015-06-30
EP2462126B1 (de) 2015-07-15
CN102471288A (zh) 2012-05-23
AR077797A1 (es) 2011-09-21
US8658790B2 (en) 2014-02-25
WO2011015526A1 (de) 2011-02-10
US8993753B2 (en) 2015-03-31
CN102471288B (zh) 2014-10-22
US20110183987A1 (en) 2011-07-28
DK2462126T3 (en) 2015-09-07
TW201120013A (en) 2011-06-16
EP2462126A1 (de) 2012-06-13
HUE025400T2 (en) 2016-02-29
JP2013501025A (ja) 2013-01-10
EA201200219A1 (ru) 2012-11-30
PL2462126T3 (pl) 2015-11-30
BR112012002104A2 (pt) 2015-09-15
IL216969A0 (en) 2012-02-29
ES2549770T3 (es) 2015-11-02
UY32830A (es) 2011-03-31
EP2289881A1 (de) 2011-03-02
AU2010280852B2 (en) 2015-04-02
KR20120049248A (ko) 2012-05-16
NZ597698A (en) 2014-03-28
CA2767963A1 (en) 2011-02-10
MX2012001089A (es) 2012-02-28
EA023562B1 (ru) 2016-06-30

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