MX2012001089A - Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. - Google Patents

Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos.

Info

Publication number
MX2012001089A
MX2012001089A MX2012001089A MX2012001089A MX2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A
Authority
MX
Mexico
Prior art keywords
heterocyclic compounds
bicyclic heterocyclic
diseases
stereoselective synthesis
salts
Prior art date
Application number
MX2012001089A
Other languages
English (en)
Inventor
Marco Santagostino
Markus Ostermeier
Juergen Daeubler
Guenther Huchler
Stephan Kling
Original Assignee
Boehringer Ingleheim Internat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingleheim Internat Gmbh filed Critical Boehringer Ingleheim Internat Gmbh
Publication of MX2012001089A publication Critical patent/MX2012001089A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación estereoselectiva de compuestos de las fórmulas (lA) y (IB) (ver fórmula (1A) y (1B)) y de sus sales, en particular sus sales fisiológicamente compatibles con ácidos y bases inorgánicos u orgánicos, las cuales muestran propiedades farmacéuticas valiosas, en particular un efecto inhibidor sobre la transducción de señales mediadas por tirosinquinasas, a su utilización para el tratamiento de enfermedades, en particular enfermedades tumorales, tales como la hiperplasia benigna de próstata (HBP), enfermedades pulmonares y de las vías respiratorias.
MX2012001089A 2009-08-06 2010-07-30 Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. MX2012001089A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167393A EP2289881A1 (de) 2009-08-06 2009-08-06 Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
PCT/EP2010/061096 WO2011015526A1 (de) 2009-08-06 2010-07-30 Verfahren zur stereoselektiven synthese bicyclischer heterocyclen

Publications (1)

Publication Number Publication Date
MX2012001089A true MX2012001089A (es) 2012-02-28

Family

ID=41205591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001089A MX2012001089A (es) 2009-08-06 2010-07-30 Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos.

Country Status (21)

Country Link
US (2) US8658790B2 (es)
EP (2) EP2289881A1 (es)
JP (1) JP2013501025A (es)
KR (1) KR20120049248A (es)
CN (1) CN102471288B (es)
AR (1) AR077797A1 (es)
AU (1) AU2010280852B2 (es)
BR (1) BR112012002104A2 (es)
CA (1) CA2767963A1 (es)
CL (1) CL2012000159A1 (es)
DK (1) DK2462126T3 (es)
EA (1) EA023562B1 (es)
ES (1) ES2549770T3 (es)
HU (1) HUE025400T2 (es)
IL (1) IL216969A (es)
MX (1) MX2012001089A (es)
NZ (1) NZ597698A (es)
PL (1) PL2462126T3 (es)
TW (1) TW201120013A (es)
UY (1) UY32830A (es)
WO (1) WO2011015526A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AP3531A (en) * 2011-02-01 2016-01-13 Boehringer Ingelheim Int 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
AU2013218119A1 (en) * 2012-02-09 2014-07-17 Boehringer Ingelheim International Gmbh Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes
JP2015524400A (ja) * 2012-07-19 2015-08-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ９−［４−（３−クロロ−２−フルオロ−フェニルアミノ）−７−メトキシ−キナゾリン−６−イルオキシ］−１，４−ジアザ−スピロ［５．５］ウンデカン−５−オンのフマル酸塩、その薬物としての使用及び調製
EP4126847A1 (en) 2020-03-30 2023-02-08 ENYO Pharma Quinazolinone derivatives and uses thereof for treating a cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813014A (en) 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
KR20090116782A (ko) * 2007-02-06 2009-11-11 베링거 인겔하임 인터내셔날 게엠베하 바이사이클릭 헤테로사이클, 당해 화합물을 함유하는 약물, 이의 용도 및 이의 제조방법
ME02338B (me) * 2007-10-26 2013-02-28 Japan Tobacco Inc Spiro-ciklično jedinjenje i njegova upotreba u medicinske svrhe
DK2245026T3 (da) * 2008-02-07 2012-10-15 Boehringer Ingelheim Int Spirocycliske heterocycler, lægemiddel indeholdende disse forbindelser, deres anvendelse og fremgangsmåde til deres fremstilling
WO2010015524A1 (de) * 2008-08-08 2010-02-11 Boehringer Ingelheim International Gmbh Verfahren zur stereoselektiven synthese bicyclischer heterocyclen
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AP3531A (en) 2011-02-01 2016-01-13 Boehringer Ingelheim Int 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
AU2013218119A1 (en) * 2012-02-09 2014-07-17 Boehringer Ingelheim International Gmbh Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes

Also Published As

Publication number Publication date
EP2462126B1 (de) 2015-07-15
JP2013501025A (ja) 2013-01-10
US8993753B2 (en) 2015-03-31
EP2289881A1 (de) 2011-03-02
US20140135495A1 (en) 2014-05-15
DK2462126T3 (en) 2015-09-07
NZ597698A (en) 2014-03-28
US8658790B2 (en) 2014-02-25
KR20120049248A (ko) 2012-05-16
BR112012002104A2 (pt) 2015-09-15
EA201200219A1 (ru) 2012-11-30
CL2012000159A1 (es) 2012-08-31
WO2011015526A1 (de) 2011-02-10
TW201120013A (en) 2011-06-16
AU2010280852B2 (en) 2015-04-02
ES2549770T3 (es) 2015-11-02
EA023562B1 (ru) 2016-06-30
CA2767963A1 (en) 2011-02-10
AU2010280852A1 (en) 2012-02-09
HUE025400T2 (en) 2016-02-29
CN102471288A (zh) 2012-05-23
CN102471288B (zh) 2014-10-22
EP2462126A1 (de) 2012-06-13
US20110183987A1 (en) 2011-07-28
UY32830A (es) 2011-03-31
IL216969A0 (en) 2012-02-29
IL216969A (en) 2015-06-30
AR077797A1 (es) 2011-09-21
PL2462126T3 (pl) 2015-11-30

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