MX2012001089A - Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. - Google Patents

Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos.

Info

Publication number
MX2012001089A
MX2012001089A MX2012001089A MX2012001089A MX2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A MX 2012001089 A MX2012001089 A MX 2012001089A
Authority
MX
Mexico
Prior art keywords
heterocyclic compounds
bicyclic heterocyclic
diseases
stereoselective synthesis
salts
Prior art date
Application number
MX2012001089A
Other languages
English (en)
Inventor
Marco Santagostino
Markus Ostermeier
Juergen Daeubler
Guenther Huchler
Stephan Kling
Original Assignee
Boehringer Ingleheim Internat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingleheim Internat Gmbh filed Critical Boehringer Ingleheim Internat Gmbh
Publication of MX2012001089A publication Critical patent/MX2012001089A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación estereoselectiva de compuestos de las fórmulas (lA) y (IB) (ver fórmula (1A) y (1B)) y de sus sales, en particular sus sales fisiológicamente compatibles con ácidos y bases inorgánicos u orgánicos, las cuales muestran propiedades farmacéuticas valiosas, en particular un efecto inhibidor sobre la transducción de señales mediadas por tirosinquinasas, a su utilización para el tratamiento de enfermedades, en particular enfermedades tumorales, tales como la hiperplasia benigna de próstata (HBP), enfermedades pulmonares y de las vías respiratorias.
MX2012001089A 2009-08-06 2010-07-30 Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos. MX2012001089A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09167393A EP2289881A1 (de) 2009-08-06 2009-08-06 Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
PCT/EP2010/061096 WO2011015526A1 (de) 2009-08-06 2010-07-30 Verfahren zur stereoselektiven synthese bicyclischer heterocyclen

Publications (1)

Publication Number Publication Date
MX2012001089A true MX2012001089A (es) 2012-02-28

Family

ID=41205591

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001089A MX2012001089A (es) 2009-08-06 2010-07-30 Procedimientos para la sintesis estereoselectiva de heterociclos biciclicos.

Country Status (21)

Country Link
US (2) US8658790B2 (es)
EP (2) EP2289881A1 (es)
JP (1) JP2013501025A (es)
KR (1) KR20120049248A (es)
CN (1) CN102471288B (es)
AR (1) AR077797A1 (es)
AU (1) AU2010280852B2 (es)
BR (1) BR112012002104A2 (es)
CA (1) CA2767963A1 (es)
CL (1) CL2012000159A1 (es)
DK (1) DK2462126T3 (es)
EA (1) EA023562B1 (es)
ES (1) ES2549770T3 (es)
HU (1) HUE025400T2 (es)
IL (1) IL216969A (es)
MX (1) MX2012001089A (es)
NZ (1) NZ597698A (es)
PL (1) PL2462126T3 (es)
TW (1) TW201120013A (es)
UY (1) UY32830A (es)
WO (1) WO2011015526A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
EP2670736B1 (de) * 2011-02-01 2017-03-15 Boehringer Ingelheim International GmbH 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-chinazolin-6- yloxy]-1,4-diaza-spiro[5.5]undecan-5-on dimaleat, dessen verwendung als arzneimittel und dessen herstellung
AU2013218119A1 (en) * 2012-02-09 2014-07-17 Boehringer Ingelheim International Gmbh Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes
EP2875020B1 (en) * 2012-07-19 2017-09-06 Boehringer Ingelheim International GmbH Process for the preparation of a fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one
WO2021198188A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI324597B (en) 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
MX2009007610A (es) * 2007-02-06 2009-07-24 Boehringer Ingelheim Int Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.
TWI421070B (zh) * 2007-10-26 2014-01-01 Japan Tobacco Inc 螺化合物及其醫藥用途
EP2245026B1 (de) * 2008-02-07 2012-08-01 Boehringer Ingelheim International GmbH Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
JP5611207B2 (ja) * 2008-08-08 2014-10-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式複素環の立体選択的調製方法
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
EP2670736B1 (de) 2011-02-01 2017-03-15 Boehringer Ingelheim International GmbH 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-chinazolin-6- yloxy]-1,4-diaza-spiro[5.5]undecan-5-on dimaleat, dessen verwendung als arzneimittel und dessen herstellung
AU2013218119A1 (en) * 2012-02-09 2014-07-17 Boehringer Ingelheim International Gmbh Method for stereoselective synthesis of 1,4-protected 9-hydroxy-5-oxo-1,4-diaza-spiro [5.5] undecanes

Also Published As

Publication number Publication date
WO2011015526A1 (de) 2011-02-10
EA201200219A1 (ru) 2012-11-30
UY32830A (es) 2011-03-31
IL216969A0 (en) 2012-02-29
US8993753B2 (en) 2015-03-31
PL2462126T3 (pl) 2015-11-30
IL216969A (en) 2015-06-30
CN102471288B (zh) 2014-10-22
ES2549770T3 (es) 2015-11-02
US8658790B2 (en) 2014-02-25
CA2767963A1 (en) 2011-02-10
AR077797A1 (es) 2011-09-21
HUE025400T2 (en) 2016-02-29
KR20120049248A (ko) 2012-05-16
CN102471288A (zh) 2012-05-23
EP2462126B1 (de) 2015-07-15
TW201120013A (en) 2011-06-16
AU2010280852B2 (en) 2015-04-02
US20110183987A1 (en) 2011-07-28
US20140135495A1 (en) 2014-05-15
NZ597698A (en) 2014-03-28
JP2013501025A (ja) 2013-01-10
EP2289881A1 (de) 2011-03-02
BR112012002104A2 (pt) 2015-09-15
EA023562B1 (ru) 2016-06-30
CL2012000159A1 (es) 2012-08-31
DK2462126T3 (en) 2015-09-07
EP2462126A1 (de) 2012-06-13
AU2010280852A1 (en) 2012-02-09

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