WO2007023073A3 - Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents

Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung Download PDF

Info

Publication number
WO2007023073A3
WO2007023073A3 PCT/EP2006/065000 EP2006065000W WO2007023073A3 WO 2007023073 A3 WO2007023073 A3 WO 2007023073A3 EP 2006065000 W EP2006065000 W EP 2006065000W WO 2007023073 A3 WO2007023073 A3 WO 2007023073A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
bicyclic heterocycles
diseases
medicaments
compounds use
Prior art date
Application number
PCT/EP2006/065000
Other languages
English (en)
French (fr)
Other versions
WO2007023073A2 (de
Inventor
Frank Himmelsbach
Birgit Jung
Original Assignee
Boehringer Ingelheim Int
Boehringer Ingelheim Pharma
Frank Himmelsbach
Birgit Jung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Boehringer Ingelheim Pharma, Frank Himmelsbach, Birgit Jung filed Critical Boehringer Ingelheim Int
Priority to CA002619037A priority Critical patent/CA2619037A1/en
Priority to US11/996,886 priority patent/US20100234371A1/en
Priority to JP2008527427A priority patent/JP2009506990A/ja
Priority to EP06778135A priority patent/EP1919900A2/de
Publication of WO2007023073A2 publication Critical patent/WO2007023073A2/de
Publication of WO2007023073A3 publication Critical patent/WO2007023073A3/de
Priority to US13/027,669 priority patent/US20110136806A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Die vorliegende Erfindung betrifft bicyclische Heterocyclen der allgemeinen Formel (I), in der Ra, Rb, Rc, Rd, Re und X wie im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere, deren Gemische und deren Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren, welche wertvolle pharmakologische Eigenschaften aufweisen, insbesondere eine Hemmwirkung auf die durch Tyrosinkinasen vermittelte Signaltransduktion, deren Verwendung zur Behandlung von Krankheiten, insbesondere von Tumorerkrankungen sowie der benignen Prostatahyperplasie (BPH), von Erkrankungen der Lunge und der Atemwege und deren Herstellung.
PCT/EP2006/065000 2005-08-22 2006-08-03 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung WO2007023073A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002619037A CA2619037A1 (en) 2005-08-22 2006-08-03 Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
US11/996,886 US20100234371A1 (en) 2005-08-22 2006-08-03 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof
JP2008527427A JP2009506990A (ja) 2005-08-22 2006-08-03 二環式複素環、これら化合物を含む医薬、それらの使用及びそれらの製造方法
EP06778135A EP1919900A2 (de) 2005-08-22 2006-08-03 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
US13/027,669 US20110136806A1 (en) 2005-08-22 2011-02-15 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05107679 2005-08-22
EP05107679.2 2005-08-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/027,669 Continuation US20110136806A1 (en) 2005-08-22 2011-02-15 Bicyclic heterocycles, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
WO2007023073A2 WO2007023073A2 (de) 2007-03-01
WO2007023073A3 true WO2007023073A3 (de) 2007-05-18

Family

ID=35789008

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/065000 WO2007023073A2 (de) 2005-08-22 2006-08-03 Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Country Status (5)

Country Link
US (2) US20100234371A1 (de)
EP (1) EP1919900A2 (de)
JP (1) JP2009506990A (de)
CA (1) CA2619037A1 (de)
WO (1) WO2007023073A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1921070A1 (de) * 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
TWI377944B (en) 2007-06-05 2012-12-01 Hanmi Holdings Co Ltd Novel amide derivative for inhibiting the growth of cancer cells
WO2009098061A1 (de) 2008-02-07 2009-08-13 Boehringer Ingelheim International Gmbh Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
RU2010146474A (ru) * 2008-04-16 2012-05-27 Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. (De) Производные хинолина в качестве ингибиторов axl киназ
JP5539351B2 (ja) * 2008-08-08 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
CN102452988B (zh) * 2010-10-27 2016-01-27 中国科学院化学研究所 一种喹唑啉衍生物及其制备方法
KR101317809B1 (ko) 2011-06-07 2013-10-16 한미약품 주식회사 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물
KR20140096571A (ko) 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
KR101645112B1 (ko) 2013-03-06 2016-08-02 아스트라제네카 아베 표피 성장 인자 수용체의 활성화 돌연변이체 형태의 퀴나졸린 억제제

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042058A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2003082290A1 (de) * 2002-03-30 2003-10-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg 4- ( n-phenylamino ) -chinazoline/chinoline als tyrosinkinaseinhibitoren
WO2003082831A1 (en) * 2002-03-28 2003-10-09 Astrazeneca Ab 4-anilino quinazoline derivatives as antiproliferative agents
WO2005012290A1 (en) * 2003-07-29 2005-02-10 Astrazeneca Ab Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
WO2005026151A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005026150A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042058A1 (de) * 2000-08-26 2002-03-07 Boehringer Ingelheim Pharma Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
WO2003082831A1 (en) * 2002-03-28 2003-10-09 Astrazeneca Ab 4-anilino quinazoline derivatives as antiproliferative agents
WO2003082290A1 (de) * 2002-03-30 2003-10-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg 4- ( n-phenylamino ) -chinazoline/chinoline als tyrosinkinaseinhibitoren
WO2005012290A1 (en) * 2003-07-29 2005-02-10 Astrazeneca Ab Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
WO2005026151A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors

Also Published As

Publication number Publication date
EP1919900A2 (de) 2008-05-14
CA2619037A1 (en) 2007-03-01
WO2007023073A2 (de) 2007-03-01
US20110136806A1 (en) 2011-06-09
US20100234371A1 (en) 2010-09-16
JP2009506990A (ja) 2009-02-19

Similar Documents

Publication Publication Date Title
WO2007023073A3 (de) Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
TW200730508A (en) Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same
RS85404A (en) 4-(n-phenylamino)- quinazolines/quinolines as tyrosine kinase inhibitors
YU14003A (sh) Biciklična heterociklična jedinjenja, lekovi koji sadrže ova jedinjenja, njihova primena i postupak za njihovo dobijanje
MY150290A (en) Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
WO2008078100A3 (en) Tricyclic amine derivatives as protein tyrosine kinase inhibitors
EA200901608A1 (ru) Производные хинаксолина в качестве ингибиторов тирозинкиназной активности киназ janus
NL300933I2 (nl) Letermovir
TW200505912A (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
AU2001295482A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
WO2008121687A3 (en) Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors
WO2007095223A3 (en) Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases
WO2007013896A3 (en) Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
WO2004108664A3 (de) Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
MY123642A (en) Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, and processes for preparing them.
NO20076502L (no) Pyrrolopyridiner nyttige som inhibitorer av proteinkinase
WO2007025540A3 (de) Substituierte imidazo[1,2b]pyridazine als kinase-inhibitoren, deren herstellung und verwendung als arzneimittel
MX2009007610A (es) Heterociclicos biciclicos, medicamentos que contienen estos compuestos, su utilizacion y procedimientos para su preparacion.
WO2008030412A3 (en) Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
WO2007115620A3 (de) Neuartige cyclobutyl-verbindungen als kinase-inhibitoren
TW200738692A (en) New substituted glycinamides, process for their manufacture and use thereof as medicaments
EA201300872A1 (ru) Дималеат 9-[4-(3-хлор-2-фторфениламино)-7-метоксихиназолин-6-илокси]-1,4-диазаспиро[5.5]ундекан-5-она, его применение в качестве лекарственного средства и его получение
WO2009030224A3 (de) Neue chinazolin- verbindungen und ihre verwendung zur therapie von krebserkrankungen
WO2006104870A3 (en) Methods of treating benign prostatic hyperplasia or lower urinary track symptoms by using pde 5 inhibitors
UY27767A1 (es) Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo, y procedimientos para su preparación.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2619037

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008527427

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006778135

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2006778135

Country of ref document: EP