AU2001295482A1 - Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof - Google Patents

Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Info

Publication number
AU2001295482A1
AU2001295482A1 AU2001295482A AU9548201A AU2001295482A1 AU 2001295482 A1 AU2001295482 A1 AU 2001295482A1 AU 2001295482 A AU2001295482 A AU 2001295482A AU 9548201 A AU9548201 A AU 9548201A AU 2001295482 A1 AU2001295482 A1 AU 2001295482A1
Authority
AU
Australia
Prior art keywords
bicyclic heterocycles
production
compounds
methods
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001295482A
Inventor
Stefan Blech
Frank Himmelsbach
Birgit Jung
Elke Langkopf
Flavio Solca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2001295482A1 publication Critical patent/AU2001295482A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to bicyclic heterocycles of general formula (I), in which Ra to Rc, A to E, and X are defined as referred to in Claim No. 1, to their tautomers, their stereoisomers, and to their salts, particularly their physiologically compatible salts with inorganic or organic acids or bases, which have valuable pharmacological properties, in particular, an inhibitive effect on the signal transduction imparted by tyrosine kinases. The invention also relates to the use of said bicyclic heterocycles for treating diseases, especially tumor diseases, disorders of the lung and of the respiratory tract, and to the production thereof.
AU2001295482A 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof Abandoned AU2001295482A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10042062A DE10042062A1 (en) 2000-08-26 2000-08-26 Bicyclic heterocycles, medicaments containing these compounds, their use and methods of preparation
DE10042062 2000-08-26
PCT/EP2001/009536 WO2002018376A1 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Publications (1)

Publication Number Publication Date
AU2001295482A1 true AU2001295482A1 (en) 2002-03-13

Family

ID=7653949

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001295482A Abandoned AU2001295482A1 (en) 2000-08-26 2001-08-18 Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof

Country Status (10)

Country Link
EP (1) EP1315720B1 (en)
JP (1) JP2004507538A (en)
AT (1) ATE299143T1 (en)
AU (1) AU2001295482A1 (en)
CA (1) CA2417907A1 (en)
DE (2) DE10042062A1 (en)
ES (1) ES2244663T3 (en)
MX (1) MXPA03001377A (en)
UY (1) UY26902A1 (en)
WO (1) WO2002018376A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201900A3 (en) 1999-06-21 2003-02-28 Boehringer Ingelheim Pharma Bicyclic heterocycles, pharmaceutical compositions containing them, their use and methods for the production thereof
DE10206505A1 (en) * 2002-02-16 2003-08-28 Boehringer Ingelheim Pharma New drug compositions based on anticholinergics and EGFR kinase inhibitors
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
TW200813014A (en) 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
DE10217689A1 (en) * 2002-04-19 2003-11-13 Boehringer Ingelheim Pharma Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation
US20040044014A1 (en) 2002-04-19 2004-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
GB0317665D0 (en) 2003-07-29 2003-09-03 Astrazeneca Ab Qinazoline derivatives
EP1667992B1 (en) 2003-09-19 2007-01-24 Astrazeneca AB Quinazoline derivatives
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (en) 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
EP1845992A1 (en) * 2005-02-04 2007-10-24 Boehringer Ingelheim International GmbH Use of tyrosine kinase inhibitors for the treatment of chronic rhinosinusitis
MX2007010399A (en) 2005-02-26 2007-09-25 Astrazeneca Ab Quinazoline derivatives as tyrosine kinase inhibitors.
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
AU2007299080B2 (en) 2006-09-18 2013-04-18 Boehringer Ingelheim International Gmbh Method for treating cancer harboring EGFR mutations
EP1921070A1 (en) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclic heterocycles, medicaments comprising them, their use and process for their preparation
JP5377332B2 (en) 2007-02-06 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Bicyclic heterocycles, drugs containing these compounds, their use and their preparation
EA019709B1 (en) 2008-02-07 2014-05-30 Бёрингер Ингельхайм Интернациональ Гмбх Spirocyclic heterocycles and use thereof as medicaments
CA2723989C (en) 2008-05-13 2017-04-25 Astrazeneca Ab Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
CA2733153C (en) 2008-08-08 2016-11-08 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
TWI385174B (en) 2008-11-10 2013-02-11 Nat Health Research Institutes Fused bicyclic and tricyclic pyrimidine compounds as tyrosine kinase inhibitors
DK2451445T3 (en) 2009-07-06 2019-06-24 Boehringer Ingelheim Int PROCEDURE FOR DRYING BIBW2992, IT'S SALTS AND SOLID PHARMACEUTICAL FORMULATIONS INCLUDING THIS ACTIVE INGREDIENT
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2249446C (en) * 1996-04-12 2008-06-17 Warner-Lambert Company Irreversible inhibitors of tyrosine kinases
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
AU3281600A (en) * 1999-02-27 2000-09-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases

Also Published As

Publication number Publication date
ES2244663T3 (en) 2005-12-16
WO2002018376A1 (en) 2002-03-07
DE10042062A1 (en) 2002-03-07
DE50106698D1 (en) 2005-08-11
UY26902A1 (en) 2002-03-22
MXPA03001377A (en) 2004-06-03
EP1315720B1 (en) 2005-07-06
EP1315720A1 (en) 2003-06-04
JP2004507538A (en) 2004-03-11
ATE299143T1 (en) 2005-07-15
CA2417907A1 (en) 2003-01-30

Similar Documents

Publication Publication Date Title
YU14003A (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
AU2001295482A1 (en) Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof
YU49603A (en) Quinazoline derivatives, medicaments containing said compounds,their utilization and method for the production thereof
MY123642A (en) Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, and processes for preparing them.
MEP45508A (en) Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof
CA2403152A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
CA2417652A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
BG105765A (en) 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
MY127771A (en) Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
CA2417050A1 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
AU688972B2 (en) Pyrimido{5,4-d}pyrimidines, drugs containing these compounds, their use, and process for preparing them
TW200730508A (en) Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same
NO984081L (en) Pyrimido [5,4-d] pyrimidines, medicaments containing these compounds, their use and method of preparation thereof
MXPA05008780A (en) Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for the production thereof.
WO2004108664A3 (en) Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing the same
WO2007023073A3 (en) Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof
MX2009007610A (en) Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof.
WO2000055162A3 (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
MY140484A (en) Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them
CY1116921T1 (en) Bicyclic heterocyclic compounds, medicinal products containing these compounds, their use and method for their production
YU60501A (en) 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases