WO2004108664A3 - Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents
Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung Download PDFInfo
- Publication number
- WO2004108664A3 WO2004108664A3 PCT/EP2004/005965 EP2004005965W WO2004108664A3 WO 2004108664 A3 WO2004108664 A3 WO 2004108664A3 EP 2004005965 W EP2004005965 W EP 2004005965W WO 2004108664 A3 WO2004108664 A3 WO 2004108664A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- bicyclic heterocycles
- preparing
- same
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002526995A CA2526995A1 (en) | 2003-06-06 | 2004-06-02 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing the same |
EP04739543A EP1641767A2 (de) | 2003-06-06 | 2004-06-02 | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
JP2006508256A JP2006527176A (ja) | 2003-06-06 | 2004-06-02 | 二環式複素環化合物、該化合物を含む医薬品、その使用と製造方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10326186A DE10326186A1 (de) | 2003-06-06 | 2003-06-06 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
DE10326186.9 | 2003-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004108664A2 WO2004108664A2 (de) | 2004-12-16 |
WO2004108664A3 true WO2004108664A3 (de) | 2005-05-26 |
Family
ID=33482765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/005965 WO2004108664A2 (de) | 2003-06-06 | 2004-06-02 | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Country Status (11)
Country | Link |
---|---|
US (3) | US7196091B2 (de) |
EP (1) | EP1641767A2 (de) |
JP (1) | JP2006527176A (de) |
AR (1) | AR044604A1 (de) |
CA (1) | CA2526995A1 (de) |
CL (1) | CL2004001409A1 (de) |
DE (1) | DE10326186A1 (de) |
PE (1) | PE20050227A1 (de) |
TW (1) | TW200510341A (de) |
UY (1) | UY28347A1 (de) |
WO (1) | WO2004108664A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3686610B2 (ja) * | 1999-06-21 | 2005-08-24 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 二環式複素環化合物、その化合物を含む医薬組成物、使用及び調製方法 |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
DE10204462A1 (de) * | 2002-02-05 | 2003-08-07 | Boehringer Ingelheim Pharma | Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung inflammatorischer Prozesse |
US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
US7456189B2 (en) * | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
US20050096332A1 (en) * | 2003-10-30 | 2005-05-05 | Boehringer Ingelheim International Gmbh | Use of tyrosine kinase inhibitors for the treatment of inflammatory processes |
EP1904458A1 (de) * | 2005-07-04 | 2008-04-02 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung von chinazolinonderivaten |
CA2629244C (en) | 2005-11-11 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
US20090306105A1 (en) * | 2006-03-09 | 2009-12-10 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and process for preparing them |
SI2068880T1 (sl) | 2006-09-18 | 2012-08-31 | Boehringer Ingelheim Int | Postopek za zdravljenje raka, ki vsebuje mutacije EGFR |
EP1921070A1 (de) * | 2006-11-10 | 2008-05-14 | Boehringer Ingelheim Pharma GmbH & Co. KG | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung |
KR20090116782A (ko) * | 2007-02-06 | 2009-11-11 | 베링거 인겔하임 인터내셔날 게엠베하 | 바이사이클릭 헤테로사이클, 당해 화합물을 함유하는 약물, 이의 용도 및 이의 제조방법 |
ME01461B (me) * | 2008-02-07 | 2014-04-20 | Boehringer Ingelheim Int | Spirociklični heterocikli, ljekovi koji sadrže navedeno jedinjenje, njihova primjena i postupak za njihovu proizvodnju. |
CA2733153C (en) * | 2008-08-08 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
ES2731901T3 (es) | 2009-07-06 | 2019-11-19 | Boehringer Ingelheim Int | Proceso para el secado de BIBW2992, de sus sales y de formulaciones farmacéuticas sólidas que comprenden este ingrediente activo |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
CN105399689B (zh) * | 2015-12-03 | 2017-03-01 | 中国人民解放军南京军区南京总医院 | 一种新型喹唑啉衍生物lu1503及其制备方法和应用 |
CN105418517B (zh) * | 2015-12-03 | 2017-03-22 | 中国人民解放军南京军区南京总医院 | 一种新型喹唑啉衍生物lu1509及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996033980A1 (en) * | 1995-04-27 | 1996-10-31 | Zeneca Limited | Quinazoline derivatives |
WO2000055141A1 (en) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, and processes for preparing them |
WO2002018351A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0824525B1 (de) * | 1995-04-27 | 2001-06-13 | AstraZeneca AB | Chinazolin derivate |
DK1274692T3 (da) * | 2000-04-07 | 2006-10-30 | Astrazeneca Ab | Quinazolinforbindelser |
US6656946B2 (en) * | 2000-08-26 | 2003-12-02 | Boehringer Ingelheim Pharma Kg | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
-
2003
- 2003-06-06 DE DE10326186A patent/DE10326186A1/de not_active Withdrawn
-
2004
- 2004-06-02 JP JP2006508256A patent/JP2006527176A/ja active Pending
- 2004-06-02 EP EP04739543A patent/EP1641767A2/de not_active Withdrawn
- 2004-06-02 WO PCT/EP2004/005965 patent/WO2004108664A2/de active Application Filing
- 2004-06-02 CA CA002526995A patent/CA2526995A1/en not_active Abandoned
- 2004-06-03 US US10/860,453 patent/US7196091B2/en not_active Expired - Lifetime
- 2004-06-04 TW TW093116265A patent/TW200510341A/zh unknown
- 2004-06-04 UY UY28347A patent/UY28347A1/es not_active Application Discontinuation
- 2004-06-04 PE PE2004000561A patent/PE20050227A1/es not_active Application Discontinuation
- 2004-06-04 AR ARP040101931A patent/AR044604A1/es not_active Suspension/Interruption
- 2004-06-04 CL CL200401409A patent/CL2004001409A1/es unknown
-
2006
- 2006-07-28 US US11/494,926 patent/US20060264450A1/en not_active Abandoned
-
2010
- 2010-06-30 US US12/826,927 patent/US20100267718A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996033980A1 (en) * | 1995-04-27 | 1996-10-31 | Zeneca Limited | Quinazoline derivatives |
WO2000055141A1 (en) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, and processes for preparing them |
WO2002018351A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung |
Non-Patent Citations (3)
Title |
---|
BARKER, A. J. ET AL: "Studies leading to the identification of ZD1839 (iressa): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 11(14), 1911-1914 CODEN: BMCLE8; ISSN: 0960-894X, 2001, XP002303977 * |
GORE, JEFF ET AL.: "The Structure of a Human Metabolite of Pholcodine", AUST. J. CHEM., vol. 49, no. 11, 1996, pages 1235 - 1242, XP009044167 * |
KASHIMA, CHOJI; HARADA, KAZUO: "Synthesis and Reaction of Optically Active Morpholinones", J. CHEM. SOC. PERKIN TRANS. 1, 1988, pages 1521 - 1526, XP009044168 * |
Also Published As
Publication number | Publication date |
---|---|
US20060264450A1 (en) | 2006-11-23 |
CL2004001409A1 (es) | 2005-05-06 |
EP1641767A2 (de) | 2006-04-05 |
US7196091B2 (en) | 2007-03-27 |
CA2526995A1 (en) | 2004-12-16 |
US20100267718A1 (en) | 2010-10-21 |
UY28347A1 (es) | 2005-01-31 |
US20050014772A1 (en) | 2005-01-20 |
WO2004108664A2 (de) | 2004-12-16 |
JP2006527176A (ja) | 2006-11-30 |
PE20050227A1 (es) | 2005-05-18 |
TW200510341A (en) | 2005-03-16 |
DE10326186A1 (de) | 2004-12-23 |
AR044604A1 (es) | 2005-09-21 |
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