UY32830A - Procedimientos para la sintesis estereoselectiva de heterocíclos bicíclicos - Google Patents

Procedimientos para la sintesis estereoselectiva de heterocíclos bicíclicos

Info

Publication number
UY32830A
UY32830A UY0001032830A UY32830A UY32830A UY 32830 A UY32830 A UY 32830A UY 0001032830 A UY0001032830 A UY 0001032830A UY 32830 A UY32830 A UY 32830A UY 32830 A UY32830 A UY 32830A
Authority
UY
Uruguay
Prior art keywords
diseases
procedures
stereoselective synthesis
bicyclic heterocycles
salts
Prior art date
Application number
UY0001032830A
Other languages
English (en)
Inventor
Huchler Guenther
Ostermeier Markus
Daeubler Juergen
Kling Stephan
Santagostino Marco
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY32830A publication Critical patent/UY32830A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un procedimiento para la preparación estereoselectiva de compuestos de las fórmulas (1 A) y (1B) y de sus sales, en particular sus sales fisiológicamente compatibles con ácidos y bases inorgánicos u orgánicos, las cuales muestran propiedades farmacéuticas valiosas, en particular un efecto inhibidor sobre la transducción de señales mediadas por tirosinquinasas, a su utilización para el tratamiento de enfermedades, en particular enfermedades tumorales, tales como la hiperplasia benigna de próstata (HBP), enfermedades pulmonares y de las vías respiratorias.
UY0001032830A 2009-08-06 2010-08-05 Procedimientos para la sintesis estereoselectiva de heterocíclos bicíclicos UY32830A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09167393A EP2289881A1 (de) 2009-08-06 2009-08-06 Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen

Publications (1)

Publication Number Publication Date
UY32830A true UY32830A (es) 2011-03-31

Family

ID=41205591

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032830A UY32830A (es) 2009-08-06 2010-08-05 Procedimientos para la sintesis estereoselectiva de heterocíclos bicíclicos

Country Status (21)

Country Link
US (2) US8658790B2 (es)
EP (2) EP2289881A1 (es)
JP (1) JP2013501025A (es)
KR (1) KR20120049248A (es)
CN (1) CN102471288B (es)
AR (1) AR077797A1 (es)
AU (1) AU2010280852B2 (es)
BR (1) BR112012002104A2 (es)
CA (1) CA2767963A1 (es)
CL (1) CL2012000159A1 (es)
DK (1) DK2462126T3 (es)
EA (1) EA023562B1 (es)
ES (1) ES2549770T3 (es)
HU (1) HUE025400T2 (es)
IL (1) IL216969A (es)
MX (1) MX2012001089A (es)
NZ (1) NZ597698A (es)
PL (1) PL2462126T3 (es)
TW (1) TW201120013A (es)
UY (1) UY32830A (es)
WO (1) WO2011015526A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
EA023573B1 (ru) * 2011-02-01 2016-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Дималеат 9-[4-(3-хлор-2-фторфениламино)-7-метоксихиназолин-6-илокси]-1,4-диазаспиро[5.5]ундекан-5-она, его применение в качестве лекарственного средства и его получение
JP6105631B2 (ja) 2012-02-09 2017-03-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １，４−保護９−ヒドロキシ−５−オキソ−１，４−ジアザ−スピロ［５．５］ウンデカンの立体選択的合成方法
WO2014012859A1 (en) * 2012-07-19 2014-01-23 Boehringer Ingelheim International Gmbh Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as medicament and the preparation thereof
EP4126847A1 (en) 2020-03-30 2023-02-08 ENYO Pharma Quinazolinone derivatives and uses thereof for treating a cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813014A (en) 2002-03-28 2008-03-16 Astrazeneca Ab Quinazoline derivatives
WO2008095847A1 (de) * 2007-02-06 2008-08-14 Boehringer Ingelheim International Gmbh Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
BRPI0818687A2 (pt) * 2007-10-26 2017-05-02 Japan Tobacco Inc composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença.
WO2009098061A1 (de) * 2008-02-07 2009-08-13 Boehringer Ingelheim International Gmbh Spirocyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
EP2313377B1 (de) * 2008-08-08 2016-01-06 Boehringer Ingelheim International Gmbh Verfahren zur stereoselektiven synthese bicyclischer heterocyclen
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
EA023573B1 (ru) 2011-02-01 2016-06-30 Бёрингер Ингельхайм Интернациональ Гмбх Дималеат 9-[4-(3-хлор-2-фторфениламино)-7-метоксихиназолин-6-илокси]-1,4-диазаспиро[5.5]ундекан-5-она, его применение в качестве лекарственного средства и его получение
JP6105631B2 (ja) * 2012-02-09 2017-03-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １，４−保護９−ヒドロキシ−５−オキソ−１，４−ジアザ−スピロ［５．５］ウンデカンの立体選択的合成方法

Also Published As

Publication number Publication date
AU2010280852A1 (en) 2012-02-09
TW201120013A (en) 2011-06-16
EP2289881A1 (de) 2011-03-02
AU2010280852B2 (en) 2015-04-02
CL2012000159A1 (es) 2012-08-31
US8993753B2 (en) 2015-03-31
WO2011015526A1 (de) 2011-02-10
US20140135495A1 (en) 2014-05-15
EA201200219A1 (ru) 2012-11-30
IL216969A (en) 2015-06-30
HUE025400T2 (en) 2016-02-29
EP2462126A1 (de) 2012-06-13
PL2462126T3 (pl) 2015-11-30
ES2549770T3 (es) 2015-11-02
MX2012001089A (es) 2012-02-28
KR20120049248A (ko) 2012-05-16
DK2462126T3 (en) 2015-09-07
BR112012002104A2 (pt) 2015-09-15
NZ597698A (en) 2014-03-28
US20110183987A1 (en) 2011-07-28
IL216969A0 (en) 2012-02-29
CA2767963A1 (en) 2011-02-10
CN102471288A (zh) 2012-05-23
US8658790B2 (en) 2014-02-25
CN102471288B (zh) 2014-10-22
EP2462126B1 (de) 2015-07-15
AR077797A1 (es) 2011-09-21
EA023562B1 (ru) 2016-06-30
JP2013501025A (ja) 2013-01-10

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20190214