UY31322A1 - Amidas heterocíclicas y sus métodos de uso-975 - Google Patents

Amidas heterocíclicas y sus métodos de uso-975

Info

Publication number
UY31322A1
UY31322A1 UY31322A UY31322A UY31322A1 UY 31322 A1 UY31322 A1 UY 31322A1 UY 31322 A UY31322 A UY 31322A UY 31322 A UY31322 A UY 31322A UY 31322 A1 UY31322 A1 UY 31322A1
Authority
UY
Uruguay
Prior art keywords
methods
heterocyclic
compounds
amidas
diseases
Prior art date
Application number
UY31322A
Other languages
English (en)
Inventor
Bin Yang
Daniel John Russell
Benjamin Fauber
Hird Alexander
James Janetka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31322A1 publication Critical patent/UY31322A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente divulgación se refiere a compuestos de amida heterocíclica que son útiles para inhibir la ruta de Hedgehog y a su uso en el tratamiento de enfermedades o trastornos médicos mediados de manera exclusiva o parcial por la inhibición de la ruta de Hedgehog. También se divulgan métodos para la fabricación de esos compuestos, composiciones farmacéuticas de esos compuestos, composiciones farmacéuticas de sos compuestos y el uso de éstos en la fabricación de medicamentos para el tratamiento de las enfermedades y los trastonos médicos en un sujeto.
UY31322A 2007-09-05 2008-09-04 Amidas heterocíclicas y sus métodos de uso-975 UY31322A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97010707P 2007-09-05 2007-09-05
US3666108P 2008-03-14 2008-03-14

Publications (1)

Publication Number Publication Date
UY31322A1 true UY31322A1 (es) 2009-04-30

Family

ID=39938463

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31322A UY31322A1 (es) 2007-09-05 2008-09-04 Amidas heterocíclicas y sus métodos de uso-975

Country Status (5)

Country Link
AR (1) AR068376A1 (es)
PE (1) PE20091092A1 (es)
TW (1) TW200916458A (es)
UY (1) UY31322A1 (es)
WO (1) WO2009030952A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010258800B2 (en) 2009-06-09 2013-10-10 Nantbio, Inc. Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling
CA2785204C (en) * 2010-01-07 2016-01-05 Selexagen Therapeutics, Inc. Hedgehog inhibitors
WO2011095807A1 (en) * 2010-02-07 2011-08-11 Astrazeneca Ab Combinations of mek and hh inhibitors
CN101993415B (zh) * 2010-09-15 2013-08-14 北京韩美药品有限公司 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
CN103570625A (zh) * 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
CN109890390A (zh) * 2016-11-04 2019-06-14 上海瑛派药业有限公司 Hedgehog通路抑制剂在治疗纤维化疾病中的应用
CN107281214A (zh) * 2017-06-06 2017-10-24 北京工业大学 氢分子液体/气体在制备抑制肿瘤干细胞药物中的应用
CN109369634B (zh) * 2018-12-19 2021-07-27 陕西国际商贸学院 具有抗肿瘤活性的2-甲氧基烟酰胺衍生物制备方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04007838A (es) * 2002-02-12 2004-10-15 Smithkline Beecham Corp Derivados de nicotamida utiles como inhibidores p38.
EP1496905B1 (en) * 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2005325267B2 (en) * 2004-04-30 2010-11-04 Curis Inc. Quinoxaline inhibitors of the hedgehog signalling pathway
KR20150090263A (ko) * 2004-09-02 2015-08-05 제넨테크, 인크. 헤지호그 신호전달에 대한 피리딜 억제제
US7816369B2 (en) * 2004-11-03 2010-10-19 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
EP1933834A1 (en) * 2005-10-12 2008-06-25 Biolipox AB Benzoxazoles useful in the treatment of inflammation
PE20080948A1 (es) * 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog

Also Published As

Publication number Publication date
PE20091092A1 (es) 2009-08-27
WO2009030952A2 (en) 2009-03-12
AR068376A1 (es) 2009-11-11
WO2009030952A3 (en) 2009-05-07
TW200916458A (en) 2009-04-16

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Effective date: 20120613