UY31322A1 - HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975 - Google Patents
HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975Info
- Publication number
- UY31322A1 UY31322A1 UY31322A UY31322A UY31322A1 UY 31322 A1 UY31322 A1 UY 31322A1 UY 31322 A UY31322 A UY 31322A UY 31322 A UY31322 A UY 31322A UY 31322 A1 UY31322 A1 UY 31322A1
- Authority
- UY
- Uruguay
- Prior art keywords
- methods
- heterocyclic
- compounds
- amidas
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente divulgación se refiere a compuestos de amida heterocíclica que son útiles para inhibir la ruta de Hedgehog y a su uso en el tratamiento de enfermedades o trastornos médicos mediados de manera exclusiva o parcial por la inhibición de la ruta de Hedgehog. También se divulgan métodos para la fabricación de esos compuestos, composiciones farmacéuticas de esos compuestos, composiciones farmacéuticas de sos compuestos y el uso de éstos en la fabricación de medicamentos para el tratamiento de las enfermedades y los trastonos médicos en un sujeto.The present disclosure relates to heterocyclic amide compounds that are useful for inhibiting the Hedgehog pathway and its use in the treatment of diseases or medical disorders mediated exclusively or partially by the inhibition of the Hedgehog pathway. Methods for the manufacture of those compounds, pharmaceutical compositions of those compounds, pharmaceutical compositions of these compounds and their use in the manufacture of medicaments for the treatment of diseases and medical disorders in a subject are also disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97010707P | 2007-09-05 | 2007-09-05 | |
US3666108P | 2008-03-14 | 2008-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31322A1 true UY31322A1 (en) | 2009-04-30 |
Family
ID=39938463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY31322A UY31322A1 (en) | 2007-09-05 | 2008-09-04 | HETEROCYCLIC AMIDAS AND ITS METHODS OF USE-975 |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR068376A1 (en) |
PE (1) | PE20091092A1 (en) |
TW (1) | TW200916458A (en) |
UY (1) | UY31322A1 (en) |
WO (1) | WO2009030952A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9345699B2 (en) | 2009-06-09 | 2016-05-24 | Nantbioscience, Inc. | Isoquinoline, quinoline, and quinazoline derivatives as inhibitors of hedgehog signaling |
WO2011085128A1 (en) * | 2010-01-07 | 2011-07-14 | Selexagen Therapeutics, Inc. | Hedgehog inhibitors |
WO2011095807A1 (en) * | 2010-02-07 | 2011-08-11 | Astrazeneca Ab | Combinations of mek and hh inhibitors |
CN101993415B (en) * | 2010-09-15 | 2013-08-14 | 北京韩美药品有限公司 | Compound as Hedgehog path inhibitor, medicine composition containing same and application thereof |
CN103570625A (en) * | 2012-07-19 | 2014-02-12 | 南京英派药业有限公司 | N-(3-aryl-heteroaryl)-4-aryl-aryl carboxamide and analog as hedgehog pathway inhibitors and application thereof |
US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
UY36294A (en) | 2014-09-12 | 2016-04-29 | Novartis Ag | COMPOUNDS AND COMPOSITIONS AS QUINASA INHIBITORS |
US10973829B2 (en) | 2016-09-19 | 2021-04-13 | Novartis Ag | Therapeutic uses of a C-RAF inhibitor |
CN109890390A (en) * | 2016-11-04 | 2019-06-14 | 上海瑛派药业有限公司 | Application of the Hedgehog pathway inhibitor in treatment fibrotic disease |
US11266653B2 (en) | 2017-05-02 | 2022-03-08 | Novartis Ag | Combination therapy |
CN107281214A (en) * | 2017-06-06 | 2017-10-24 | 北京工业大学 | Hydrogen molecule liquid/gas is preparing the application in suppressing tumor stem cell medicine |
CN109369634B (en) * | 2018-12-19 | 2021-07-27 | 陕西国际商贸学院 | Preparation method and application of 2-methoxynicotinamide derivative with antitumor activity |
WO2022266236A1 (en) | 2021-06-18 | 2022-12-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ533865A (en) * | 2002-02-12 | 2006-02-24 | Smithkline Beecham Corp | Nicotinamide derivates useful as p38 inhibitors |
US7655674B2 (en) * | 2002-04-22 | 2010-02-02 | The Johns Hopkins University | Modulators of hedgehog signaling pathways, compositions and uses related thereto |
PL1745041T3 (en) * | 2004-04-30 | 2012-11-30 | Genentech Inc | Quinoxaline inhibitors of the hedgehog signalling pathway |
KR20200118909A (en) * | 2004-09-02 | 2020-10-16 | 제넨테크, 인크. | Pyridyl inhibitors of hedgehog signalling |
EP1807074B1 (en) * | 2004-11-03 | 2013-10-23 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
WO2007042816A1 (en) * | 2005-10-12 | 2007-04-19 | Biolipox Ab | Benzoxazoles useful in the treatment of inflammation |
PE20080948A1 (en) * | 2006-07-25 | 2008-09-10 | Irm Llc | IMIDAZOLE DERIVATIVES AS MODULATORS OF THE HEDGEHOG PATH |
-
2008
- 2008-09-04 TW TW097133986A patent/TW200916458A/en unknown
- 2008-09-04 UY UY31322A patent/UY31322A1/en unknown
- 2008-09-04 WO PCT/GB2008/050782 patent/WO2009030952A2/en active Application Filing
- 2008-09-05 PE PE2008001563A patent/PE20091092A1/en not_active Application Discontinuation
- 2008-09-05 AR ARP080103877A patent/AR068376A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009030952A2 (en) | 2009-03-12 |
WO2009030952A3 (en) | 2009-05-07 |
AR068376A1 (en) | 2009-11-11 |
TW200916458A (en) | 2009-04-16 |
PE20091092A1 (en) | 2009-08-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DESI | Application deemed to be withdrawn |
Effective date: 20120613 |