PE20221414A1 - Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico - Google Patents

Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico

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Publication number
PE20221414A1
PE20221414A1 PE2022000593A PE2022000593A PE20221414A1 PE 20221414 A1 PE20221414 A1 PE 20221414A1 PE 2022000593 A PE2022000593 A PE 2022000593A PE 2022000593 A PE2022000593 A PE 2022000593A PE 20221414 A1 PE20221414 A1 PE 20221414A1
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PE
Peru
Prior art keywords
naphthyridine
methoxyphenyl
dihydro
cyano
dimethyl
Prior art date
Application number
PE2022000593A
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English (en)
Inventor
Johannes Platzek
Kai Lovis
Martin Alba Hernandez
Silja Brady
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20221414A1 publication Critical patent/PE20221414A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a un procedimiento para preparar esteres aciloximetilicos del acido (4S)-(4- ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico. Ademas, la invencion tambien se refiere al uso de una hidrolasa en un procedimiento para preparar esteres aciloximetilicos del acido (4S)-(4- ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico.
PE2022000593A 2019-10-17 2020-10-12 Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico PE20221414A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19203821 2019-10-17
PCT/EP2020/078611 WO2021074077A1 (de) 2019-10-17 2020-10-12 Verfahren zur herstellung von acyloxymethylestern der (4s) -(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbonsäure

Publications (1)

Publication Number Publication Date
PE20221414A1 true PE20221414A1 (es) 2022-09-20

Family

ID=68281309

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2022000593A PE20221414A1 (es) 2019-10-17 2020-10-12 Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2- metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxilico

Country Status (16)

Country Link
US (1) US20240150344A1 (es)
EP (1) EP4045500A1 (es)
JP (1) JP2022553225A (es)
KR (1) KR20220084102A (es)
CN (1) CN114555599B (es)
AU (1) AU2020365314A1 (es)
BR (1) BR112022005605A2 (es)
CA (1) CA3157823A1 (es)
CL (1) CL2022000941A1 (es)
CO (1) CO2022004464A2 (es)
CR (1) CR20220161A (es)
IL (1) IL292194A (es)
JO (1) JOP20220148A1 (es)
MX (1) MX2022004480A (es)
PE (1) PE20221414A1 (es)
WO (1) WO2021074077A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114214375B (zh) * 2021-12-27 2024-03-19 江苏威凯尔医药科技有限公司 (r)-3-(4-卤代-1h-吡唑-1-基)-3-环戊基丙酸酯的制备方法
CN115340539B (zh) * 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
WO2023205164A1 (en) 2022-04-18 2023-10-26 Teva Pharmaceuticals International Gmbh Processes for the preparation of finerenone
WO2023223188A1 (en) * 2022-05-16 2023-11-23 Glenmark Life Sciences Limited Process for the preparation of finerenone and intermediates thereof
CN115322194B (zh) * 2022-08-23 2024-04-09 浙江国邦药业有限公司 一种非奈利酮中间体羧酸拆分方法
CN116715664A (zh) * 2023-06-12 2023-09-08 常州制药厂有限公司 一种非奈利酮关键中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234821A (en) * 1990-09-01 1993-08-10 Kazuo Achiwa Process for preparing 1,4 dihydropyridine compounds
DE102007009494A1 (de) * 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
PE20170141A1 (es) * 2014-08-01 2017-04-02 Bayer Pharma AG Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificacion para su uso como principio activo farmaceutico
SI3337800T1 (sl) * 2015-08-21 2019-08-30 Bayer Pharma Aktiengesellschaft, Postopek priprave (4S)-4-(4-ciano-2-metoksifenil)-5-etoksi-2,8-dimetil-1,4-dihidro- 1-6-nafthiridin-3-karboksamida in njegovo čiščenje, za uporabo kot aktivna farmacevtska učinkovina
EP3337799A1 (de) * 2015-08-21 2018-06-27 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung der metaboliten von (4s) und (4r)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxamid und deren verwendung
CN108409731B (zh) * 2018-03-07 2020-11-20 西华大学 芳基取代的1H-吡啶[3,4-b]吲哚-3-羧酸甲酯的手性拆分

Also Published As

Publication number Publication date
CA3157823A1 (en) 2021-04-22
JP2022553225A (ja) 2022-12-22
AU2020365314A1 (en) 2022-05-12
CL2022000941A1 (es) 2022-11-11
WO2021074077A1 (de) 2021-04-22
CO2022004464A2 (es) 2022-04-29
CR20220161A (es) 2022-06-17
BR112022005605A2 (pt) 2022-07-19
MX2022004480A (es) 2022-05-06
JOP20220148A1 (ar) 2023-01-30
KR20220084102A (ko) 2022-06-21
US20240150344A1 (en) 2024-05-09
CN114555599A (zh) 2022-05-27
EP4045500A1 (de) 2022-08-24
IL292194A (en) 2022-06-01
CN114555599B (zh) 2024-06-07

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