CY1123038T1 - Παρασκευη της 4,5,6,7-τετραϋδροϊσοξαζολο[5,4-c]πυριδιν-3-ολης - Google Patents

Παρασκευη της 4,5,6,7-τετραϋδροϊσοξαζολο[5,4-c]πυριδιν-3-ολης

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Publication number
CY1123038T1
CY1123038T1 CY20201100279T CY201100279T CY1123038T1 CY 1123038 T1 CY1123038 T1 CY 1123038T1 CY 20201100279 T CY20201100279 T CY 20201100279T CY 201100279 T CY201100279 T CY 201100279T CY 1123038 T1 CY1123038 T1 CY 1123038T1
Authority
CY
Cyprus
Prior art keywords
tetrahydroisoxazolo
pyridin
preparation
dihydropyridine
hydroxy
Prior art date
Application number
CY20201100279T
Other languages
English (en)
Inventor
Carla De Faveri
Florian Anton Martin Huber
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of CY1123038T1 publication Critical patent/CY1123038T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με μία διεργασία για τη σύνθεση της 4,5,6,7-τετραϋδροϊσοξαζολο[5,4-c]πυριδιν-3-όλης συντομογραφούμενης ΤΗΙΡ, η οποία έχει την κοινόχρηστη διεθνή ονομασία γαμποξαδόλη, ξεκινώντας από πυρρολιδιν-2-όνη. Η διεργασία περιλαμβάνει μία νέα άμεση διεργασία για να ληφθεί ο ενδιάμεσος 5-υδροξυ-3,6-διυδροπυριδινο-1,4 (2Η) -5-δικαρβοξυλικός διμεθυλεστέρας ή ο ενδιάμεσος 5-υδροξυ-3,6-διυδροπυριδινο-1,4(2Η)-δικαρβοξυλικός διαιθυλεστέρας.
CY20201100279T 2015-03-24 2020-03-24 Παρασκευη της 4,5,6,7-τετραϋδροϊσοξαζολο[5,4-c]πυριδιν-3-ολης CY1123038T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201500181 2015-03-24
PCT/EP2016/056244 WO2016150953A1 (en) 2015-03-24 2016-03-22 Manufacture of 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol

Publications (1)

Publication Number Publication Date
CY1123038T1 true CY1123038T1 (el) 2021-10-29

Family

ID=55587289

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100279T CY1123038T1 (el) 2015-03-24 2020-03-24 Παρασκευη της 4,5,6,7-τετραϋδροϊσοξαζολο[5,4-c]πυριδιν-3-ολης

Country Status (21)

Country Link
US (2) US10626123B2 (el)
EP (1) EP3274331B1 (el)
JP (1) JP6735284B2 (el)
KR (1) KR102363715B1 (el)
CN (1) CN107428776B (el)
AU (1) AU2016236239B2 (el)
CA (1) CA2977437C (el)
CY (1) CY1123038T1 (el)
DK (1) DK3274331T3 (el)
ES (1) ES2781978T3 (el)
HK (1) HK1248689A1 (el)
HR (1) HRP20200488T1 (el)
HU (1) HUE048370T2 (el)
LT (1) LT3274331T (el)
MA (1) MA41802B1 (el)
ME (1) ME03673B (el)
PL (1) PL3274331T3 (el)
PT (1) PT3274331T (el)
RS (1) RS60063B1 (el)
SI (1) SI3274331T1 (el)
WO (1) WO2016150953A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA41802B1 (fr) 2015-03-24 2020-04-30 H Lundbeck As Fabrication de 4,5,6,7-tétrahydroisozaxolo[5,4-c]pyridine-3-ol
PL3720838T3 (pl) 2017-12-05 2022-12-19 Basf Se Sole organicznych kwasów sulfonowych i estrów aminokwasów i sposoby ich wytwarzania
CN113395962A (zh) 2018-11-21 2021-09-14 Certego治疗公司 加波沙朵用于降低自杀风险和快速缓解抑郁症
WO2020144030A1 (en) 2019-01-08 2020-07-16 Basf Se Process for the preparation of organosulfate salts of amino acids esters
KR20230028244A (ko) 2020-05-20 2023-02-28 썰테고 테라퓨틱스 아이엔씨. 고리 중수소화 가복사돌 및 정신 장애의 치료를 위한 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK270378A (da) 1977-06-20 1978-12-21 Krogsgaard Larsen P Isoxazolderivater
IL89351A0 (en) 1988-03-14 1989-09-10 Lundbeck & Co As H 4,5,6,7-tetrahydroisothiazolo(4,5-c)pyridines,process for their preparation and pharmaceutical compositions containing them
DE19525598C2 (de) 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel
PL1641456T3 (pl) 2003-06-25 2010-08-31 H Lundbeck As Gaboksadol do leczenia depresji i innych zaburzeń afektywnych
AR045540A1 (es) 2003-09-05 2005-11-02 Lundbeck & Co As H Metodo de elaboracion de 4,5,6,7 tetrahidroisoxazol [5,4-c] piridin-3-ol (thip)
CA2683434A1 (en) * 2007-04-05 2008-10-16 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
MA41802B1 (fr) 2015-03-24 2020-04-30 H Lundbeck As Fabrication de 4,5,6,7-tétrahydroisozaxolo[5,4-c]pyridine-3-ol

Also Published As

Publication number Publication date
JP2018509447A (ja) 2018-04-05
ME03673B (me) 2020-10-20
LT3274331T (lt) 2020-04-10
PL3274331T3 (pl) 2020-06-15
EP3274331B1 (en) 2020-02-26
MA41802B1 (fr) 2020-04-30
US20200223865A1 (en) 2020-07-16
SI3274331T1 (sl) 2020-08-31
KR102363715B1 (ko) 2022-02-15
AU2016236239B2 (en) 2020-06-25
US11332478B2 (en) 2022-05-17
ES2781978T3 (es) 2020-09-09
HUE048370T2 (hu) 2020-07-28
KR20170129778A (ko) 2017-11-27
PT3274331T (pt) 2020-04-02
EP3274331A1 (en) 2018-01-31
AU2016236239A1 (en) 2017-08-31
US20180065984A1 (en) 2018-03-08
CN107428776A (zh) 2017-12-01
HRP20200488T1 (hr) 2020-06-26
HK1248689A1 (zh) 2018-10-19
CN107428776B (zh) 2020-10-23
CA2977437C (en) 2023-07-04
DK3274331T3 (da) 2020-03-23
RS60063B1 (sr) 2020-04-30
CA2977437A1 (en) 2016-09-29
WO2016150953A1 (en) 2016-09-29
JP6735284B2 (ja) 2020-08-05
US10626123B2 (en) 2020-04-21

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