EA201891769A1 - СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ ПИРРОЛО[3,2-d]ПИРИМИДИНА И ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ - Google Patents

СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ ПИРРОЛО[3,2-d]ПИРИМИДИНА И ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ

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Publication number
EA201891769A1
EA201891769A1 EA201891769A EA201891769A EA201891769A1 EA 201891769 A1 EA201891769 A1 EA 201891769A1 EA 201891769 A EA201891769 A EA 201891769A EA 201891769 A EA201891769 A EA 201891769A EA 201891769 A1 EA201891769 A1 EA 201891769A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
compound
pyrimidine
obtaining
intermediate compounds
Prior art date
Application number
EA201891769A
Other languages
English (en)
Other versions
EA034581B1 (ru
Inventor
Чжаочжун Дин
Фей Сунь
Инху Ху
Илун Чжоу
Жуй Чжао
Лин Ян
Original Assignee
Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. filed Critical Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Publication of EA201891769A1 publication Critical patent/EA201891769A1/ru
Publication of EA034581B1 publication Critical patent/EA034581B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения соединения пирроло[3,2-d]пиримидина (соединения, представленного формулой I) и соответствующих промежуточных соединений.
EA201891769A 2016-02-05 2017-02-04 Способ получения соединения пирроло[3,2-d]пиримидина и промежуточных соединений EA034581B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (2)

Publication Number Publication Date
EA201891769A1 true EA201891769A1 (ru) 2019-04-30
EA034581B1 EA034581B1 (ru) 2020-02-21

Family

ID=59500148

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891769A EA034581B1 (ru) 2016-02-05 2017-02-04 Способ получения соединения пирроло[3,2-d]пиримидина и промежуточных соединений

Country Status (29)

Country Link
US (2) US10654856B2 (ru)
EP (1) EP3412673B1 (ru)
JP (1) JP6877449B2 (ru)
KR (1) KR102371500B1 (ru)
CN (2) CN107043378A (ru)
AR (1) AR107549A1 (ru)
AU (1) AU2017214134B2 (ru)
BR (1) BR112018015879B1 (ru)
CA (1) CA3013520C (ru)
CL (1) CL2018002094A1 (ru)
DK (1) DK3412673T3 (ru)
EA (1) EA034581B1 (ru)
ES (1) ES2852323T3 (ru)
HK (1) HK1259183A1 (ru)
HR (1) HRP20210103T1 (ru)
HU (1) HUE053455T2 (ru)
IL (1) IL260999B (ru)
LT (1) LT3412673T (ru)
MX (1) MX2018009502A (ru)
MY (1) MY190551A (ru)
NZ (1) NZ744885A (ru)
PH (1) PH12018501642B1 (ru)
PL (1) PL3412673T3 (ru)
PT (1) PT3412673T (ru)
SG (1) SG11201806685VA (ru)
SI (1) SI3412673T1 (ru)
TW (1) TW201728590A (ru)
UA (1) UA124100C2 (ru)
WO (1) WO2017133686A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
CA3170551A1 (en) 2020-03-02 2021-09-10 Yong Taik Lim Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
WO2022031057A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도
JP2023536953A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的制御が可能なアジュバントを含むｍＲＮＡワクチン
EP4194008A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
EP2364314B1 (en) 2008-12-09 2014-03-12 Gilead Sciences, Inc. Modulators of toll-like receptors
HUE037064T2 (hu) * 2012-10-10 2018-08-28 Janssen Sciences Ireland Uc Pirrolo[3,2-d]-pirimidin származékok vírusos fertõzések és egyéb betegségek kezelésére
JP6228223B2 (ja) * 2012-11-20 2017-11-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 新規化合物
US9550785B2 (en) * 2012-11-20 2017-01-24 Glaxosmithkline Llc Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
KR102139847B1 (ko) * 2014-05-01 2020-07-31 노파르티스 아게 톨-유사 수용체 7 효능제로서의 화합물 및 조성물
SG11201701169XA (en) * 2014-08-15 2017-03-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Pyrrolopyrimidine compounds used as tlr7 agonist
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
MX2018005708A (es) 2015-11-05 2018-11-09 Chia Tai Tianqing Pharmaceutical Group Co Ltd Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7.
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途

Also Published As

Publication number Publication date
BR112018015879A2 (pt) 2018-12-26
MY190551A (en) 2022-04-27
EA034581B1 (ru) 2020-02-21
PH12018501642A1 (en) 2019-06-03
CA3013520C (en) 2022-07-19
LT3412673T (lt) 2021-03-10
HUE053455T2 (hu) 2021-06-28
US20200239484A1 (en) 2020-07-30
SG11201806685VA (en) 2018-09-27
JP2019505531A (ja) 2019-02-28
AU2017214134B2 (en) 2020-08-27
WO2017133686A1 (zh) 2017-08-10
EP3412673A1 (en) 2018-12-12
PL3412673T3 (pl) 2021-07-26
NZ744885A (en) 2022-07-01
UA124100C2 (uk) 2021-07-21
HRP20210103T1 (hr) 2021-03-05
CL2018002094A1 (es) 2018-12-07
PH12018501642B1 (en) 2019-06-03
PT3412673T (pt) 2021-02-15
JP6877449B2 (ja) 2021-05-26
AU2017214134A1 (en) 2018-08-23
US10654856B2 (en) 2020-05-19
DK3412673T3 (da) 2021-01-18
HK1259183A1 (zh) 2019-11-29
SI3412673T1 (sl) 2021-04-30
KR20180104724A (ko) 2018-09-21
US20190040072A1 (en) 2019-02-07
AR107549A1 (es) 2018-05-09
EP3412673B1 (en) 2020-11-25
BR112018015879B1 (pt) 2024-02-15
ES2852323T3 (es) 2021-09-13
EP3412673A4 (en) 2019-07-03
CN108602832A (zh) 2018-09-28
CN107043378A (zh) 2017-08-15
CA3013520A1 (en) 2017-08-10
KR102371500B1 (ko) 2022-03-07
IL260999B (en) 2021-02-28
TW201728590A (zh) 2017-08-16
MX2018009502A (es) 2018-12-11
CN108602832B (zh) 2020-10-09

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