EA201891769A1 - СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ ПИРРОЛО[3,2-d]ПИРИМИДИНА И ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ - Google Patents

СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ ПИРРОЛО[3,2-d]ПИРИМИДИНА И ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ

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Publication number
EA201891769A1
EA201891769A1 EA201891769A EA201891769A EA201891769A1 EA 201891769 A1 EA201891769 A1 EA 201891769A1 EA 201891769 A EA201891769 A EA 201891769A EA 201891769 A EA201891769 A EA 201891769A EA 201891769 A1 EA201891769 A1 EA 201891769A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
compound
pyrimidine
obtaining
intermediate compounds
Prior art date
Application number
EA201891769A
Other languages
English (en)
Other versions
EA034581B1 (ru
Inventor
Чжаочжун Дин
Фей Сунь
Инху Ху
Илун Чжоу
Жуй Чжао
Лин Ян
Original Assignee
Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. filed Critical Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд.
Publication of EA201891769A1 publication Critical patent/EA201891769A1/ru
Publication of EA034581B1 publication Critical patent/EA034581B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения соединения пирроло[3,2-d]пиримидина (соединения, представленного формулой I) и соответствующих промежуточных соединений.
EA201891769A 2016-02-05 2017-02-04 Способ получения соединения пирроло[3,2-d]пиримидина и промежуточных соединений EA034581B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (2)

Publication Number Publication Date
EA201891769A1 true EA201891769A1 (ru) 2019-04-30
EA034581B1 EA034581B1 (ru) 2020-02-21

Family

ID=59500148

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891769A EA034581B1 (ru) 2016-02-05 2017-02-04 Способ получения соединения пирроло[3,2-d]пиримидина и промежуточных соединений

Country Status (29)

Country Link
US (2) US10654856B2 (ru)
EP (1) EP3412673B1 (ru)
JP (1) JP6877449B2 (ru)
KR (1) KR102371500B1 (ru)
CN (2) CN107043378A (ru)
AR (1) AR107549A1 (ru)
AU (1) AU2017214134B2 (ru)
BR (1) BR112018015879B1 (ru)
CA (1) CA3013520C (ru)
CL (1) CL2018002094A1 (ru)
DK (1) DK3412673T3 (ru)
EA (1) EA034581B1 (ru)
ES (1) ES2852323T3 (ru)
HK (1) HK1259183A1 (ru)
HR (1) HRP20210103T1 (ru)
HU (1) HUE053455T2 (ru)
IL (1) IL260999B (ru)
LT (1) LT3412673T (ru)
MX (1) MX2018009502A (ru)
MY (1) MY190551A (ru)
NZ (1) NZ744885A (ru)
PH (1) PH12018501642A1 (ru)
PL (1) PL3412673T3 (ru)
PT (1) PT3412673T (ru)
SG (1) SG11201806685VA (ru)
SI (1) SI3412673T1 (ru)
TW (1) TW201728590A (ru)
UA (1) UA124100C2 (ru)
WO (1) WO2017133686A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
US20230100429A1 (en) 2020-03-02 2023-03-30 Progeneer Inc. Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
WO2022031021A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적 제어가 가능한 아주번트를 포함하는 mrna 백신
CN116056725A (zh) 2020-08-04 2023-05-02 蛋白科技先鋒 活性位点暂时灭活的功能性药物与Toll样受体7或8激动剂的缀合物及其用途
JP2023536945A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
EA021377B9 (ru) 2008-12-09 2015-09-30 Джилид Сайэнс, Инк. Модуляторы толл-подобных рецепторов
NZ705589A (en) * 2012-10-10 2019-05-31 Janssen Sciences Ireland Uc Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
WO2014081645A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
EP2922550B1 (en) * 2012-11-20 2017-04-19 Glaxosmithkline LLC Novel compounds
CR20160512A (es) * 2014-05-01 2016-12-21 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll 7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
EA032824B1 (ru) * 2014-08-15 2019-07-31 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Пирролопиримидиновые соединения, используемые в качестве агониста tlr7
EA035116B1 (ru) * 2015-11-05 2020-04-29 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. 7-(тиазол-5-ил)пирролопиримидин в качестве агониста рецептора tlr7
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途

Also Published As

Publication number Publication date
AR107549A1 (es) 2018-05-09
KR102371500B1 (ko) 2022-03-07
EP3412673A1 (en) 2018-12-12
WO2017133686A1 (zh) 2017-08-10
US20190040072A1 (en) 2019-02-07
HUE053455T2 (hu) 2021-06-28
US20200239484A1 (en) 2020-07-30
PT3412673T (pt) 2021-02-15
PL3412673T3 (pl) 2021-07-26
UA124100C2 (uk) 2021-07-21
MX2018009502A (es) 2018-12-11
CN108602832A (zh) 2018-09-28
HRP20210103T1 (hr) 2021-03-05
MY190551A (en) 2022-04-27
JP2019505531A (ja) 2019-02-28
BR112018015879A2 (pt) 2018-12-26
BR112018015879B1 (pt) 2024-02-15
AU2017214134A1 (en) 2018-08-23
CA3013520C (en) 2022-07-19
NZ744885A (en) 2022-07-01
JP6877449B2 (ja) 2021-05-26
EP3412673B1 (en) 2020-11-25
TW201728590A (zh) 2017-08-16
PH12018501642B1 (en) 2019-06-03
PH12018501642A1 (en) 2019-06-03
SI3412673T1 (sl) 2021-04-30
HK1259183A1 (zh) 2019-11-29
EA034581B1 (ru) 2020-02-21
EP3412673A4 (en) 2019-07-03
SG11201806685VA (en) 2018-09-27
IL260999B (en) 2021-02-28
ES2852323T3 (es) 2021-09-13
DK3412673T3 (da) 2021-01-18
US10654856B2 (en) 2020-05-19
CL2018002094A1 (es) 2018-12-07
CN108602832B (zh) 2020-10-09
KR20180104724A (ko) 2018-09-21
AU2017214134B2 (en) 2020-08-27
CN107043378A (zh) 2017-08-15
CA3013520A1 (en) 2017-08-10
LT3412673T (lt) 2021-03-10

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