MX2018009502A - Metodo para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. - Google Patents

Metodo para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios.

Info

Publication number
MX2018009502A
MX2018009502A MX2018009502A MX2018009502A MX2018009502A MX 2018009502 A MX2018009502 A MX 2018009502A MX 2018009502 A MX2018009502 A MX 2018009502A MX 2018009502 A MX2018009502 A MX 2018009502A MX 2018009502 A MX2018009502 A MX 2018009502A
Authority
MX
Mexico
Prior art keywords
pyrrolo
intermediates
preparing
pyrimidine compound
formula
Prior art date
Application number
MX2018009502A
Other languages
English (en)
Inventor
Ding Zhaozhong
Yang Ling
Sun Fei
Hu Yinghu
Zhou Yilong
Zhao Rui
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of MX2018009502A publication Critical patent/MX2018009502A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invencion se refiere a un metodo para preparar un compuesto de pirrolo[3,2-d]pirimidina (el compuesto representado por la formula I) e intermediarios correspondientes.
MX2018009502A 2016-02-05 2017-02-04 Metodo para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. MX2018009502A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (1)

Publication Number Publication Date
MX2018009502A true MX2018009502A (es) 2018-12-11

Family

ID=59500148

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009502A MX2018009502A (es) 2016-02-05 2017-02-04 Metodo para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios.

Country Status (29)

Country Link
US (2) US10654856B2 (es)
EP (1) EP3412673B1 (es)
JP (1) JP6877449B2 (es)
KR (1) KR102371500B1 (es)
CN (2) CN107043378A (es)
AR (1) AR107549A1 (es)
AU (1) AU2017214134B2 (es)
BR (1) BR112018015879B1 (es)
CA (1) CA3013520C (es)
CL (1) CL2018002094A1 (es)
DK (1) DK3412673T3 (es)
EA (1) EA034581B1 (es)
ES (1) ES2852323T3 (es)
HK (1) HK1259183A1 (es)
HR (1) HRP20210103T1 (es)
HU (1) HUE053455T2 (es)
IL (1) IL260999B (es)
LT (1) LT3412673T (es)
MX (1) MX2018009502A (es)
MY (1) MY190551A (es)
NZ (1) NZ744885A (es)
PH (1) PH12018501642B1 (es)
PL (1) PL3412673T3 (es)
PT (1) PT3412673T (es)
SG (1) SG11201806685VA (es)
SI (1) SI3412673T1 (es)
TW (1) TW201728590A (es)
UA (1) UA124100C2 (es)
WO (1) WO2017133686A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194006A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof
WO2022031011A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적으로 작용하는 아주번트 앙상블

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
CN102272134B (zh) 2008-12-09 2013-10-16 吉里德科学公司 Toll样受体调节剂
ES2670513T3 (es) * 2012-10-10 2018-05-30 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidínicos para el tratamiento de infecciones víricas y otras enfermedades
US9550785B2 (en) * 2012-11-20 2017-01-24 Glaxosmithkline Llc Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
RS56233B1 (sr) * 2012-11-20 2017-11-30 Glaxosmithkline Llc Nova jedinjenja
PE20170325A1 (es) * 2014-05-01 2017-04-21 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
LT3190113T (lt) * 2014-08-15 2021-08-25 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Pirolopirimidino junginiai, naudotini kaip tlr7 agonistai
JP6524355B2 (ja) 2015-11-05 2019-06-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. Ｔｌｒ７アゴニストとしての７−（チアゾール−５−イル）ピロロピリミジン化合物
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途

Also Published As

Publication number Publication date
JP2019505531A (ja) 2019-02-28
EA201891769A1 (ru) 2019-04-30
EP3412673B1 (en) 2020-11-25
DK3412673T3 (da) 2021-01-18
CA3013520C (en) 2022-07-19
CN108602832A (zh) 2018-09-28
LT3412673T (lt) 2021-03-10
US20200239484A1 (en) 2020-07-30
BR112018015879B1 (pt) 2024-02-15
HUE053455T2 (hu) 2021-06-28
SG11201806685VA (en) 2018-09-27
CA3013520A1 (en) 2017-08-10
AR107549A1 (es) 2018-05-09
PH12018501642A1 (en) 2019-06-03
EP3412673A1 (en) 2018-12-12
KR102371500B1 (ko) 2022-03-07
HK1259183A1 (zh) 2019-11-29
AU2017214134B2 (en) 2020-08-27
HRP20210103T1 (hr) 2021-03-05
EP3412673A4 (en) 2019-07-03
BR112018015879A2 (pt) 2018-12-26
WO2017133686A1 (zh) 2017-08-10
JP6877449B2 (ja) 2021-05-26
UA124100C2 (uk) 2021-07-21
SI3412673T1 (sl) 2021-04-30
EA034581B1 (ru) 2020-02-21
AU2017214134A1 (en) 2018-08-23
IL260999B (en) 2021-02-28
PL3412673T3 (pl) 2021-07-26
CN108602832B (zh) 2020-10-09
US20190040072A1 (en) 2019-02-07
TW201728590A (zh) 2017-08-16
US10654856B2 (en) 2020-05-19
PT3412673T (pt) 2021-02-15
NZ744885A (en) 2022-07-01
PH12018501642B1 (en) 2019-06-03
CL2018002094A1 (es) 2018-12-07
KR20180104724A (ko) 2018-09-21
ES2852323T3 (es) 2021-09-13
CN107043378A (zh) 2017-08-15
MY190551A (en) 2022-04-27

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