CO2018008253A2 - Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina - Google Patents

Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina

Info

Publication number
CO2018008253A2
CO2018008253A2 CONC2018/0008253A CO2018008253A CO2018008253A2 CO 2018008253 A2 CO2018008253 A2 CO 2018008253A2 CO 2018008253 A CO2018008253 A CO 2018008253A CO 2018008253 A2 CO2018008253 A2 CO 2018008253A2
Authority
CO
Colombia
Prior art keywords
pyrrolo
preparing
pyrimidine compounds
methyl
pyrimidine
Prior art date
Application number
CONC2018/0008253A
Other languages
English (en)
Inventor
Timothy Lee Stuk
Denis Billen
Valerie Sue Westrick
Vageesha Warnajith Liyana Gunawardana
Original Assignee
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Services Llc filed Critical Zoetis Services Llc
Publication of CO2018008253A2 publication Critical patent/CO2018008253A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se describen procesos mejorados para la preparación del compuesto de 7H-pirrolo[2,3-d]pirimidina, N-metil-1-{trans-4-[metil(7H-pirrolo[2,3-d]pirimidin-4-il)amino]ciclohexil}-metanosulfonamida, intermedios de estos y sales veterinariamente aceptables de estos (Fórmula (1)).
CONC2018/0008253A 2016-02-16 2018-08-03 Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina CO2018008253A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662295739P 2016-02-16 2016-02-16
US201662375040P 2016-08-15 2016-08-15
PCT/US2017/016778 WO2017142740A1 (en) 2016-02-16 2017-02-07 Process for preparing 7h-pyrrolo [2, 3-d] pyrimidine compounds

Publications (1)

Publication Number Publication Date
CO2018008253A2 true CO2018008253A2 (es) 2018-08-21

Family

ID=58018338

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0008253A CO2018008253A2 (es) 2016-02-16 2018-08-03 Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina

Country Status (15)

Country Link
US (1) US9926327B2 (es)
EP (1) EP3416965B1 (es)
JP (1) JP6568324B2 (es)
KR (1) KR102124449B1 (es)
CN (1) CN108699072B (es)
AU (1) AU2017221193B2 (es)
BR (1) BR112018016708B1 (es)
CA (1) CA3012589C (es)
CL (1) CL2018002344A1 (es)
CO (1) CO2018008253A2 (es)
MX (1) MX2018009912A (es)
NZ (1) NZ744341A (es)
RU (1) RU2699034C1 (es)
WO (1) WO2017142740A1 (es)
ZA (1) ZA201804871B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2022471B1 (en) * 2019-01-29 2020-08-18 Vationpharma B V Solid state forms of oclacitinib
PL3915989T3 (pl) * 2019-01-30 2023-12-11 Felicamed Biotechnology Co., Ltd Inhibitor jak i sposób jego otrzymywania
CN114761011B (zh) * 2019-08-26 2024-06-14 肯沃斯公司 用作jak1抑制剂的取代的(7h-吡咯并[2,3-d]嘧啶-4-基)氨基化合物
CN112279854B (zh) * 2020-08-25 2022-04-05 常州齐晖药业有限公司 一种7H-吡咯并[2,3-d]嘧啶化合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424213A (en) 1980-11-10 1984-01-03 Sds Biotech Corporation Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof
JP4666762B2 (ja) 1998-06-19 2011-04-06 ファイザー・プロダクツ・インク ピロロ［２．３−ｄ］ピリミジン化合物
EP1457485A1 (en) * 2003-03-14 2004-09-15 Dompé S.P.A. Sulfonic acids, their derivatives and pharmaceutical compositions containing them
US8193206B2 (en) 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
AU2006273762A1 (en) 2005-07-29 2007-02-01 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine derivatives; their intermediates and synthesis
BRPI0917459B1 (pt) * 2008-08-20 2017-09-12 Zoetis Services Llc N-methyl-1- [trans-4- [methyl (7h-pyrrol [2,3-d] pyridol [2,3-d] pyrimidine compounds, use of these in therapy and crystalline a form of n-methyl- pyrimidin-4-yl) amino] cyclohexyl} methanosulphonamide
EA201290147A1 (ru) * 2009-10-15 2012-11-30 Пфайзер Инк. Пирроло[2,3-d]пиримидиновые соединения
ES2461967T3 (es) * 2009-12-18 2014-05-21 Pfizer Inc. Compuestos de pirrolo[2,3-d]pirimidina
CN104224737A (zh) * 2010-02-24 2014-12-24 硕腾有限责任公司 兽医组合物

Also Published As

Publication number Publication date
NZ744341A (en) 2019-06-28
BR112018016708B1 (pt) 2023-11-07
MX2018009912A (es) 2018-11-29
US9926327B2 (en) 2018-03-27
KR20180100225A (ko) 2018-09-07
CN108699072A (zh) 2018-10-23
ZA201804871B (en) 2019-05-29
CA3012589C (en) 2020-05-05
JP2019505547A (ja) 2019-02-28
CN108699072B (zh) 2021-02-26
EP3416965B1 (en) 2020-10-07
WO2017142740A1 (en) 2017-08-24
AU2017221193B2 (en) 2019-03-14
CL2018002344A1 (es) 2018-09-14
US20170233397A1 (en) 2017-08-17
BR112018016708A2 (pt) 2018-12-26
CA3012589A1 (en) 2017-08-24
EP3416965A1 (en) 2018-12-26
JP6568324B2 (ja) 2019-08-28
AU2017221193A1 (en) 2018-08-09
KR102124449B1 (ko) 2020-06-26
RU2699034C1 (ru) 2019-09-03

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