CL2021000276A1 - Polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6h)-ona y método para prepararlo. - Google Patents

Polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6h)-ona y método para prepararlo.

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Publication number
CL2021000276A1
CL2021000276A1 CL2021000276A CL2021000276A CL2021000276A1 CL 2021000276 A1 CL2021000276 A1 CL 2021000276A1 CL 2021000276 A CL2021000276 A CL 2021000276A CL 2021000276 A CL2021000276 A CL 2021000276A CL 2021000276 A1 CL2021000276 A1 CL 2021000276A1
Authority
CL
Chile
Prior art keywords
phenoxyphenylamin
ylamin
methylpiperidin
pyrido
pyrimidin
Prior art date
Application number
CL2021000276A
Other languages
English (en)
Inventor
Jung-Ho Kim
Jang-Sik Choi
Hee Kyu Lee
Dong-Sik Jung
Yung-Geun Choi
Song-Eun Park
Jong-Sung Koh
Se-Won Kim
Jaekyoo Lee
Original Assignee
Oscotec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oscotec Inc filed Critical Oscotec Inc
Publication of CL2021000276A1 publication Critical patent/CL2021000276A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente patente de invención está relacionada principalmente con un polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6H)-ona y método para prepararlo.
CL2021000276A 2018-08-23 2021-02-02 Polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6h)-ona y método para prepararlo. CL2021000276A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180098681A KR20200022712A (ko) 2018-08-23 2018-08-23 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법

Publications (1)

Publication Number Publication Date
CL2021000276A1 true CL2021000276A1 (es) 2021-07-19

Family

ID=69593288

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021000276A CL2021000276A1 (es) 2018-08-23 2021-02-02 Polimorfo cristalino del clorhidrato de 8-bromo-2-(1-metilpiperidin-4-ilamin)-4-(4-fenoxifenilamin)pirido[4,3-d]pirimidin-5(6h)-ona y método para prepararlo.

Country Status (17)

Country Link
US (1) US11731969B2 (es)
EP (1) EP3842434B1 (es)
JP (2) JP2021535088A (es)
KR (2) KR20200022712A (es)
CN (1) CN112566914A (es)
AU (1) AU2019325764B2 (es)
BR (1) BR112021003298A2 (es)
CA (1) CA3108373C (es)
CL (1) CL2021000276A1 (es)
EA (1) EA202190405A1 (es)
ES (1) ES2952445T3 (es)
IL (1) IL281030B1 (es)
MX (1) MX2021001860A (es)
MY (1) MY194696A (es)
SG (1) SG11202101114WA (es)
WO (1) WO2020040467A1 (es)
ZA (1) ZA202101025B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
US11479389B2 (en) 2020-05-20 2022-10-25 Anchor Packaging, Llc Tamper evident plastic food container
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
TW202340177A (zh) 2021-12-30 2023-10-16 美商拜歐米富士恩股份有限公司 作為 flt3抑制劑之吡嗪化合物
WO2023225005A1 (en) 2022-05-17 2023-11-23 Biomea Fusion, Inc. Flt3 combination therapy for cancer and compositions therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003022209A2 (en) * 2001-09-07 2003-03-20 Teva Pharmaceutical Industries Ltd. Crystalline forms of valacyclovir hydrochloride
MX2007000983A (es) * 2005-05-23 2007-04-16 Teva Pharma Procesos para preparar la forma cristalina i de clorhidrato de cinacalcet.
EP2493313B1 (en) * 2009-10-29 2017-12-13 Genosco Kinase inhibitors
WO2013142382A1 (en) 2012-03-22 2013-09-26 Genosco Substituted pyridopyrimidine compounds and their use as flt3 inhibitors
KR20150002952A (ko) * 2013-06-27 2015-01-08 주식회사 오스코텍 피리도피리미딘 유도체를 함유하는 대사성 골 질환의 예방 및 치료용 약학 조성물
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법

Also Published As

Publication number Publication date
EP3842434A4 (en) 2022-06-08
SG11202101114WA (en) 2021-03-30
IL281030A (en) 2021-04-29
CA3108373A1 (en) 2020-02-27
BR112021003298A2 (pt) 2021-05-11
KR20240109965A (ko) 2024-07-12
CA3108373C (en) 2023-05-16
US20210292322A1 (en) 2021-09-23
AU2019325764A1 (en) 2021-03-04
EP3842434A1 (en) 2021-06-30
WO2020040467A1 (ko) 2020-02-27
AU2019325764B2 (en) 2022-03-03
EP3842434B1 (en) 2023-08-02
KR20200022712A (ko) 2020-03-04
US11731969B2 (en) 2023-08-22
IL281030B1 (en) 2024-06-01
CN112566914A (zh) 2021-03-26
EA202190405A1 (ru) 2021-05-28
MX2021001860A (es) 2021-04-19
EP3842434C0 (en) 2023-08-02
MY194696A (en) 2022-12-15
ZA202101025B (en) 2022-09-28
ES2952445T3 (es) 2023-10-31
JP2021535088A (ja) 2021-12-16
JP2023071814A (ja) 2023-05-23

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