MX368162B - Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). - Google Patents

Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Info

Publication number
MX368162B
MX368162B MX2017007429A MX2017007429A MX368162B MX 368162 B MX368162 B MX 368162B MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 368162 B MX368162 B MX 368162B
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007429A
Other languages
English (en)
Other versions
MX2017007429A (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007429A publication Critical patent/MX2017007429A/es
Publication of MX368162B publication Critical patent/MX368162B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos de pirazolopirimidina bicíclicos sustituidos de fórmula (I) novedosos que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincicial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de la infección por el virus sincicial respiratorio. (ver Fórmula).
MX2017007429A 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). MX368162B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196782 2014-12-08
PCT/EP2015/078762 WO2016091774A1 (en) 2014-12-08 2015-12-07 Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007429A MX2017007429A (es) 2017-09-28
MX368162B true MX368162B (es) 2019-09-20

Family

ID=52006929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007429A MX368162B (es) 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US9981976B2 (es)
EP (1) EP3230287B1 (es)
JP (2) JP2017537118A (es)
KR (1) KR102522832B1 (es)
CN (1) CN107001377B (es)
AU (1) AU2015359624B2 (es)
CA (1) CA2963051C (es)
EA (1) EA032081B1 (es)
ES (1) ES2704740T3 (es)
MX (1) MX368162B (es)
SG (1) SG11201704397VA (es)
WO (1) WO2016091774A1 (es)
ZA (1) ZA201703899B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016091791A1 (en) 2014-12-08 2016-06-16 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
AU2019216260B2 (en) 2018-01-31 2023-03-02 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against RSV
KR20210005569A (ko) 2018-04-23 2021-01-14 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Rsv에 대한 활성을 갖는 헤테로방향족 화합물
AU2019359166B2 (en) * 2018-10-10 2024-07-11 Curovir Ab 2,6-dimethyl-N-((pyridin-4-yl)methyl)imidazo(1,2-b)pyridazin-8-amine and 2,5-dimethyl-N-((pyridin-4-yl)methyl)pyrazolo(1,5-a)pyrimidin-7-amine derivatives for treating viral infections
AU2019389616A1 (en) * 2018-11-26 2021-04-29 Janssen Sciences Ireland Unlimited Company Further heteroaromatic compounds having activity against RSV
CA3124783A1 (en) 2018-12-27 2020-07-02 Taisho Pharmaceutical Co., Ltd. Pyrazolo[1,5-a]pyrimidine macrocyclic compound
WO2020156445A1 (zh) * 2019-01-29 2020-08-06 山东轩竹医药科技有限公司 己酮糖激酶抑制剂及其用途
JP7403661B2 (ja) * 2019-12-24 2023-12-22 杭州中美華東製薬有限公司 Ｋｈｋ阻害効果を有する化合物
JP7744350B2 (ja) 2020-01-13 2025-09-25 バージ アナリティクス，インコーポレイテッド 置換ピラゾロ－ピリミジンおよびその使用
KR102614659B1 (ko) * 2020-04-20 2023-12-19 주식회사 엘지화학 3-아자바이사이클로알킬 유도체 및 이를 포함하는 약제학적 조성물
CN113754640B (zh) * 2020-06-03 2023-02-14 山东轩竹医药科技有限公司 氘代的己酮糖激酶抑制剂及其用途
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途
CA3223875A1 (en) * 2021-06-25 2022-12-29 Shigeru Matsuoka Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections
IL309501A (en) 2021-08-19 2024-02-01 Syngenta Crop Protection Ag Method for controlling pests resistant to diamide and compounds therefor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2279641A1 (en) 1997-02-14 1998-08-20 Pola Chemical Industries, Inc. Remedies/preventives for respiratory diseases
US7304068B2 (en) * 2002-05-10 2007-12-04 Smithkline Beecham Corporation Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore
JPWO2005030773A1 (ja) 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
US8486938B2 (en) 2010-06-24 2013-07-16 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines for antiviral treatment
EP2794611B1 (en) 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
EA027855B1 (ru) * 2012-04-17 2017-09-29 Гайлид Сайэнсиз, Инк. Соединения и способы для противовирусной терапии
WO2016091791A1 (en) 2014-12-08 2016-06-16 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Also Published As

Publication number Publication date
EP3230287B1 (en) 2018-10-10
AU2015359624B2 (en) 2020-01-02
EP3230287A1 (en) 2017-10-18
MX2017007429A (es) 2017-09-28
CN107001377B (zh) 2019-09-10
JP2017537118A (ja) 2017-12-14
CA2963051A1 (en) 2016-06-16
EA032081B1 (ru) 2019-04-30
CN107001377A (zh) 2017-08-01
US20170349591A1 (en) 2017-12-07
AU2015359624A1 (en) 2017-04-13
ZA201703899B (en) 2019-01-30
ES2704740T3 (es) 2019-03-19
EA201791274A1 (ru) 2017-10-31
JP2020011991A (ja) 2020-01-23
JP6628930B1 (ja) 2020-01-15
WO2016091774A1 (en) 2016-06-16
KR102522832B1 (ko) 2023-04-17
US9981976B2 (en) 2018-05-29
KR20170090424A (ko) 2017-08-07
SG11201704397VA (en) 2017-06-29
CA2963051C (en) 2023-10-17

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