MX368162B - Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). - Google Patents

Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Info

Publication number
MX368162B
MX368162B MX2017007429A MX2017007429A MX368162B MX 368162 B MX368162 B MX 368162B MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 368162 B MX368162 B MX 368162B
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007429A
Other languages
English (en)
Other versions
MX2017007429A (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007429A publication Critical patent/MX2017007429A/es
Publication of MX368162B publication Critical patent/MX368162B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos de pirazolopirimidina bicíclicos sustituidos de fórmula (I) novedosos que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincicial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de la infección por el virus sincicial respiratorio. (ver Fórmula).
MX2017007429A 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). MX368162B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196782 2014-12-08
PCT/EP2015/078762 WO2016091774A1 (en) 2014-12-08 2015-12-07 Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007429A MX2017007429A (es) 2017-09-28
MX368162B true MX368162B (es) 2019-09-20

Family

ID=52006929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007429A MX368162B (es) 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US9981976B2 (es)
EP (1) EP3230287B1 (es)
JP (2) JP2017537118A (es)
KR (1) KR102522832B1 (es)
CN (1) CN107001377B (es)
AU (1) AU2015359624B2 (es)
CA (1) CA2963051C (es)
EA (1) EA032081B1 (es)
ES (1) ES2704740T3 (es)
MX (1) MX368162B (es)
SG (1) SG11201704397VA (es)
WO (1) WO2016091774A1 (es)
ZA (1) ZA201703899B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131673B2 (en) 2014-12-08 2018-11-20 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) * 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
CN111670189A (zh) * 2018-01-31 2020-09-15 爱尔兰詹森科学公司 对rsv具有活性的环烷基取代的吡唑并嘧啶
MA52348A (fr) 2018-04-23 2021-03-03 Janssen Sciences Ireland Unlimited Co Composés hétéroaromatiques ayant une activité contre vrs
CA3115128A1 (en) * 2018-10-10 2020-04-16 Curovir Ab 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections
EA202191482A1 (ru) * 2018-11-26 2021-12-14 Янссен Сайенсиз Айрлэнд Анлимитед Компани Другие гетероароматические соединения, обладающие активностью против rsv
WO2020138015A1 (ja) 2018-12-27 2020-07-02 大正製薬株式会社 ピラゾロ［１，５－ａ］ピリミジン大環状化合物
PH12021551635A1 (en) * 2019-01-29 2022-05-02 Shandong Xuanzhu Pharma Co Ltd Hexone glucokinase inhibitor and use thereof
EP4083034A4 (en) 2019-12-24 2023-12-06 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. ASSOCIATION WITH CHAD-INHIBITING EFFECT
KR20220140515A (ko) 2020-01-13 2022-10-18 버지 애널리틱스, 인크. 치환된 피라졸로-피리미딘 및 그의 용도
US20230203008A1 (en) * 2020-04-20 2023-06-29 Lg Chem, Ltd. 3-azabicycloalkyl derivative and pharmaceutical composition containing same
CN113754640B (zh) * 2020-06-03 2023-02-14 山东轩竹医药科技有限公司 氘代的己酮糖激酶抑制剂及其用途
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途
US20240327392A1 (en) * 2021-06-25 2024-10-03 Albius Sciences Alpha Private Limited Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections
AU2022331725A1 (en) 2021-08-19 2024-03-07 Syngenta Crop Protection Ag Method for controlling diamide resistant pests & compounds therefor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4192250B2 (ja) * 1997-02-14 2008-12-10 株式会社ポーラファルマ 呼吸器疾患治療・予防用医薬
JP2005529919A (ja) * 2002-05-10 2005-10-06 スミスクライン ビーチャム コーポレーション 治療用化合物
JPWO2005030773A1 (ja) * 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
GB0327319D0 (en) * 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
MA34392B1 (fr) 2010-06-24 2013-07-03 Gilead Sciences Inc Pyrimidines en tant qu'agents antiviraux
CA2858096C (en) 2011-12-22 2020-06-23 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
CN106986869A (zh) * 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
US10131673B2 (en) 2014-12-08 2018-11-20 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV)

Also Published As

Publication number Publication date
JP6628930B1 (ja) 2020-01-15
EP3230287A1 (en) 2017-10-18
CN107001377B (zh) 2019-09-10
AU2015359624B2 (en) 2020-01-02
KR20170090424A (ko) 2017-08-07
KR102522832B1 (ko) 2023-04-17
ZA201703899B (en) 2019-01-30
MX2017007429A (es) 2017-09-28
AU2015359624A1 (en) 2017-04-13
SG11201704397VA (en) 2017-06-29
US9981976B2 (en) 2018-05-29
JP2017537118A (ja) 2017-12-14
EA201791274A1 (ru) 2017-10-31
CA2963051A1 (en) 2016-06-16
US20170349591A1 (en) 2017-12-07
EP3230287B1 (en) 2018-10-10
EA032081B1 (ru) 2019-04-30
WO2016091774A1 (en) 2016-06-16
ES2704740T3 (es) 2019-03-19
CN107001377A (zh) 2017-08-01
JP2020011991A (ja) 2020-01-23
CA2963051C (en) 2023-10-17

Similar Documents

Publication Publication Date Title
MX2017007429A (es) Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).
PH12017501958A1 (en) Rsv antiviral pyrazolo- and triazolo-pyrimidine compounds
PH12018500437A1 (en) Novel pyrazolo [3,4-d] pyrimidine compounds or salt thereof
CL2013003051A1 (es) Compuestos derivados de pirazolo (4.3-d) pirimidinas, inhibidores de quinasa; composicion farmaceutica; y uso para el tratamiento de enfermedades y trastornos del aparato respiratorio
PH12015502780A1 (en) Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
PH12016502168B1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
IL251285A0 (en) 3-substituted 5-amino-h6-triazolo[5,4-d]pyrimidine-7,2-dione compounds for the treatment and prevention of viral infection
NZ733135A (en) Fused pyrimidine compounds for the treatment of hiv
AU2012358805A8 (en) Pyrazolo[1,5-a]pyrimidines as antiviral agents
MY179392A (en) Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
EA201591255A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-РОДСТВЕННЫХ КИНАЗ (JAK)
MX2017001284A (es) Tieno [3,2-d] pirimidina, furo[3,2-d] pirimidina y pirrolo [3,2-d] pirimidinas utiles para el tratamiento de infecciones por virus sincitial respiratorio.
WO2015120237A3 (en) 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication
WO2015110491A3 (en) Pyrazolo[1,5-a]pyrimidines as antiviral compounds
PH12020550673A1 (en) Pyrazolopyrimidines having activity against the respiratory syncytial virus (rsv)
MX2020008061A (es) Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs.
MX2020011200A (es) Compuestos heteroaromaticos que tienen actividad contra vrs.
MX2017007430A (es) Derivados triciclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicacion del virus sincitial respiratorio (vsr).
AU2014298561A8 (en) Substituted pyridine-piperazinyl analogues as RSV antiviral compounds
HK1235772A1 (en) Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
HK1248601A1 (zh) 作為激酶抑制劑的嘧啶衍生物及其治療應用

Legal Events

Date Code Title Description
FG Grant or registration