MX368162B - Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). - Google Patents

Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Info

Publication number
MX368162B
MX368162B MX2017007429A MX2017007429A MX368162B MX 368162 B MX368162 B MX 368162B MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 368162 B MX368162 B MX 368162B
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007429A
Other languages
English (en)
Other versions
MX2017007429A (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007429A publication Critical patent/MX2017007429A/es
Publication of MX368162B publication Critical patent/MX368162B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos de pirazolopirimidina bicíclicos sustituidos de fórmula (I) novedosos que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincicial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de la infección por el virus sincicial respiratorio. (ver Fórmula).
MX2017007429A 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). MX368162B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196782 2014-12-08
PCT/EP2015/078762 WO2016091774A1 (en) 2014-12-08 2015-12-07 Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007429A MX2017007429A (es) 2017-09-28
MX368162B true MX368162B (es) 2019-09-20

Family

ID=52006929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007429A MX368162B (es) 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US9981976B2 (es)
EP (1) EP3230287B1 (es)
JP (2) JP2017537118A (es)
KR (1) KR102522832B1 (es)
CN (1) CN107001377B (es)
AU (1) AU2015359624B2 (es)
CA (1) CA2963051C (es)
EA (1) EA032081B1 (es)
ES (1) ES2704740T3 (es)
MX (1) MX368162B (es)
SG (1) SG11201704397VA (es)
WO (1) WO2016091774A1 (es)
ZA (1) ZA201703899B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107207512B (zh) 2014-12-08 2019-09-10 爱尔兰詹森科学公司 对呼吸道合胞病毒(rsv)的复制具有抑制活性的哌啶取代的三环吡唑并[1，5-a]嘧啶衍生物
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
AU2019216260B2 (en) * 2018-01-31 2023-03-02 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against RSV
ES2957316T3 (es) 2018-04-23 2024-01-17 Janssen Sciences Ireland Unlimited Co Compuestos heteroaromáticos que tienen actividad contra VSR
PL3864017T3 (pl) * 2018-10-10 2024-02-19 Curovir Ab 2,6-dimetylo-n-((pirydyn-4-ylo)metylo)imidazo[1,2-b]pirydazyno-8-amina i pochodne 2,5-dimetylo-n-[(pirydyn-4-ylo)metylo]pirazolo[1,5-a]pirymidyno-7-aminy do leczenia zakażeń wirusowych
JP2022507779A (ja) * 2018-11-26 2022-01-18 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｒｓｖに対する活性を有するさらなるヘテロ芳香族化合物
EP3903788A4 (en) 2018-12-27 2022-09-07 Taisho Pharmaceutical Co., Ltd. PYRAZOLO[1,5-A] PYRIMIDINE MACROCYCLIC COMPOUND
CN116023365B (zh) * 2019-01-29 2025-02-14 轩竹生物科技股份有限公司 己酮糖激酶抑制剂及其用途
US12534477B2 (en) 2019-12-24 2026-01-27 Hangzhou Zhongmeihuadong Pharmaceutical Co. , Ltd. Compound having KHK inhibitory effect
KR20220140515A (ko) 2020-01-13 2022-10-18 버지 애널리틱스, 인크. 치환된 피라졸로-피리미딘 및 그의 용도
TWI810550B (zh) * 2020-04-20 2023-08-01 南韓商Ｌｇ化學股份有限公司 3-氮雜二環烷基衍生物及包含其之醫藥組成物
CN113754640B (zh) * 2020-06-03 2023-02-14 山东轩竹医药科技有限公司 氘代的己酮糖激酶抑制剂及其用途
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途
CA3223875A1 (en) * 2021-06-25 2022-12-29 Shigeru Matsuoka Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections
MX2024002008A (es) 2021-08-19 2024-03-05 Syngenta Crop Protection Ag Metodo para controlar plagas resistentes a diamidas y compuestos para el mismo.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69729890T2 (de) 1997-02-14 2005-07-14 Pola Chemical Industries, Inc. Heilmittel/vorbeugemittel für erkrankungen der atemwege
ES2287476T3 (es) * 2002-05-10 2007-12-16 Smithkline Beecham Corporation Pirazolopirimidinas sustituidas.
JPWO2005030773A1 (ja) 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
RS54761B1 (sr) 2010-06-24 2016-10-31 Gilead Sciences Pirazolo[1,5-a]pirimidini i-triazini kao antiviralni agensi
JP6122868B2 (ja) 2011-12-22 2017-04-26 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス剤としてのピラゾロ［１，５−ａ］ピリミジン
CN106986869A (zh) 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
CN107207512B (zh) 2014-12-08 2019-09-10 爱尔兰詹森科学公司 对呼吸道合胞病毒(rsv)的复制具有抑制活性的哌啶取代的三环吡唑并[1，5-a]嘧啶衍生物

Also Published As

Publication number Publication date
ES2704740T3 (es) 2019-03-19
JP2020011991A (ja) 2020-01-23
EA201791274A1 (ru) 2017-10-31
CA2963051C (en) 2023-10-17
AU2015359624A1 (en) 2017-04-13
US20170349591A1 (en) 2017-12-07
EP3230287B1 (en) 2018-10-10
JP6628930B1 (ja) 2020-01-15
CN107001377B (zh) 2019-09-10
CN107001377A (zh) 2017-08-01
AU2015359624B2 (en) 2020-01-02
EP3230287A1 (en) 2017-10-18
WO2016091774A1 (en) 2016-06-16
MX2017007429A (es) 2017-09-28
SG11201704397VA (en) 2017-06-29
ZA201703899B (en) 2019-01-30
CA2963051A1 (en) 2016-06-16
US9981976B2 (en) 2018-05-29
JP2017537118A (ja) 2017-12-14
EA032081B1 (ru) 2019-04-30
KR102522832B1 (ko) 2023-04-17
KR20170090424A (ko) 2017-08-07

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